任吉存


1、基本信息
姓名：任吉存 （Prof. & Dr. Jicun Ren)
职称：教授
电话：　
邮箱：jicunren@sjtu.edu.cn
主页：scce.sjtu.edu.cn
通讯地址：上海市东川路800号化学化工学院A楼216室
2、教育经历
1978-1981：安庆师范学院化学系，学士
1991-1994：武汉大学化学学院，博士
1994-1996：中南大学湘雅医学院，博士后
1996-2000：挪威卑尔根大学医学院，博士后
3、工作经历
1982-1991：安庆师范学院化学系，助教，讲师
1994-1996：湖南师范大学化学系，副教授
1997-2001：湖南师范大学化学系，教授
2001-2015：上海交通大学化学化工学院，教授
2015 - 上海交通大学，****


4、研究方向
（1）单分子（单颗粒）波动光谱与成像： 发展单分子（单颗粒）波动光谱与成像新方法，与微流控芯片技术结合，研究活细胞内生物分子、药物分子的动力学以及分子间（药物分子与靶标、蛋白-蛋白）的相互作用。
（2）光学探针设计与合成：设计合成新型的纳米光学探针和荧光分子探针，发展活细胞内生物分子的标记新方法。
（3）生物分析：基于微流控芯片电泳和纳米光学探针标记技术，发展高灵敏度的分析新方法，用于疾病标志物、环境污染物分析。


5、科研项目
主持国家重大科研仪器研制项目、国家自然科学基金重点项目、面上项目，科技部“863”专项，上海科委重点项目等。
6、荣誉奖励
2016年获教育部自然科学一等奖
2015年上海交通大学****
2008年获教育部自然科学二等奖

7、学术兼职
Electrophoresis (Wiley), Microchimica Acta (Springer), Journal of Separation Science (Wiley), Methods and Applications inFluorescence (IOP),《分析化学》,《色谱》等杂志编委, 国际荧光光谱学方法和应用大会（Methods and Applications inFluorescence, MAF)督导委员会委员(Permanent Steering Committee )。
8、教学工作
本科生：《仪器分析》
研究生：《现代仪器分析》
9、代表性论文及专著 (Selected Publications)
论文




Liyuan Deng, Xiangyi Huang*, Jicun Ren*, In Situ Study of the Drug–Target Protein Interaction in Single LivingCells by Combining Fluorescence Correlation Spectroscopy with Affinity Probes, Anal. Chem.2020, 92, 7020–7027.

Shengrong Yu, Fucai Li, Xiangyi Huang, Chaoqing Dong,* andJicun Ren*
In Situ Study of Interactions between Endogenous c-myc mRNA with CRDBP in a Single Living Cell by Combining Fluorescence CrossCorrelation Spectroscopy with Molecular Beacons,
Anal. Chem., 2020,92,2988-2996.

Zhixue Du, Jing Yu, Fucai Li, Liyun Deng, Fang Wu,Xiangyi Huang, Jan Bergstrand, Jerker Widengren, Chaoqing Dong* and Jicun Ren* Insitu monitoring p53 protein and MDM2 protein interaction in single living cellsusing single molecule fluorescence spectroscopy, Anal. Chem., 2018, 90, 6144?6151.

Lvping Cai, Liyun Deng,Xiangyi Huang*, Jicun Ren*, Catalytic Chemiluminescence Polymer Dots for Ultrasensitive InVivo Imaging of Intrinsic Reactive Oxygen Species in Mice, Anal. Chem., 2018,90, 6929?6935.

Di Su, ChaoqingDong and Jicun Ren* Quantitative Determination of Telomerase Activity by CombiningFluorescence Correlation Spectroscopy with Telomerase Repeat AmplificationProtocol, Anal.Chem., 2018,90, 10006-1013.

Fang Yi, XiangyiHuang, Jicun Ren,Simple and Sensitive Method for Determination of Protein Kinase Activity Basedon Surface Charge Change of Peptide-Modified Gold Nanoparticles As Substrates, Anal.Chem., 2018, 90, 3871?3877.

Bocheng Zhang, Chaoqing Dong and Jicun Ren* Size Distribution ofNoble Metal Nanoparticles Characterized by Combing Resonance Light ScatteringCorrelation Spectroscopy with Maximum Entropy Method , Anal. Chem., 2017, 89(22), 12609–12616.

Di Su, Chaoqing Dong, and Jicun Ren* Determination of caspase-3 activity andits inhibition constant by combination of fluorescencecorrelation spectroscopy with a microwell chip,
Anal. Chem., 2017, 89, 9788?9796.

Jinjie Wang, Chaoqing Dong, Jicun Ren* Fluorescence and scattering light cross correlationspectroscopy and its applications in homogeneous immunoassay, Anal. Chem., 2017，89, 5230?5237.

Aidi Zhang, Chaoqing Dong*, and Jicun Ren* TuningBlinking Behavior of Highly Luminescent Cesium Lead Halide Nanocrystals throughFast Anion-Exchange Reactions, J. Phys. Chem. C, 2017, 121, 13314?13323.

Heng Liu, Chaoqing Dong, Jicun Ren*, Tempo-Spatially Resolved Scattering Correlation Spectroscopy Based on Dark-Field Microscopy and Its Application to Investigate Dynamic Behaviors of Gold Nanoparticles in Live Cells,
J. Am. Chem. Soc., 2014, 136, 2775?2785.

Chaoqing Dong^*, Heng Liu, Aidi Zhang, Jicun Ren^*Controllable Blinking-to-Nonblinking Behavior of Aqueous CdTeS Alloyed Quantum Dots, Chem. Eur. J. 2014, 20(7): 1940-1946.


Chaoqing Dong^*, HengLiu, Jicun Ren^* Assessing the blinking state of fluorescent quantum dots infree solution by combining fluorescence correlation spectroscopy with ensemble spectroscopicmethods, Langmuir,2014, 30, 12969?12976.

Aidi Zhang, Chaoqing Dong, Heng Liu and Jicun Ren*, Blinking Behavior of CdSe/CdS Quantum Dots Controlled by Alkylthiols as Surface Trap Modifiers, J. Phys. Chem. C, 2013, 117, 24592?24600.

Bocheng Zhang, Tao Lan, Xiangyi Huang, Chaoqing Dong and Jicun Ren*, Sensitive Single Particle Method for Characterizing Rapid Rotational and Translational Diffusion and Aspect Ratio of Anisotropic Nanoparticles and Its Application in Immunoassays Anal. Chem., 2013, 85, 9433?9438.
Xiangyi Huang, Jicun Ren*, Nanoparticle-Based Chemiluminescence Resonance Energy Transfer: A strategy to develop new analytical methods, TrAC：Trends in Analytical Chemistry, 2012, 40, 77-89.

Lingao Ruan, Zhancheng Xu, Tao Lan, Jinjie Wang, Heng Liu, Chaodong Li Chaoqing Dong, Jicun Ren*, Highly Sensitive Method for Assay of Drug-induced Apoptosis Using Fluorescence Correlation Spectroscopy, Anal. Chem., 2012, 84, 7350?7358.
Heng Liu, Chaoqing Dong, Xiangyi Huang, Jicun Ren*, Spatially Resolved Scattering Correlation Spectroscopy Using A Total Internal Reflection (TIR) Configuration , Anal. Chem., 2012, 84, 3561?3567.

Jie Gao, Xiangyi Huang, Heng Liu, Feng Zan, Jicun Ren *, Colloidal stability of gold nanoparticles modified with thiol compounds, bioconjugation and application in cancer cell imaging, Langmuir, 2012, 28, 4464-4471.

Feng Zan, Chaoqing Dong, Heng Liu, Jicun Ren* Experimental studies on blinking behavior of single InP/ZnS quantum dots: Effects of synthetic conditions and UV irradiation, J. Phys. Chem. C, 2012, 116, 3944?3950.

Feng Zan, Jicun Ren* Gas-liquid phase synthesis of highly luminescent InP/ZnS core/shell quantum dots using zinc phosphide as a new phosphorus source, J. Mater. Chem., 2012, 22, 1794-1799.

Hua He, Chao Xie, Jicun Ren*, Non-Bleaching Fluorescence of Gold Nanoparticles and Its Applications in Cancer Cell Imaging, Anal. Chem., 2008, 80, 5951-5957.

Chaoqing Dong, Jiacheng Guo, Liwen Shao, Jicun Ren* Host-guest interaction of chaperonin GroEL and water soluble CdTe QDs and its size selective encapsulation, ChemPhysChem., 2008, 9, 2245-2251.

Huifeng Qian, Chaoqing Dong, Jinliang Peng, Xin Qiu, Yuhong Xu, Jicun Ren*, High Quality and Water-Soluble Near-Infrared Photoluminescent CdHgTe/CdS Quantum Dots Prepared by Adjusting Size and Composition，J. Phys. Chem. C., 2007, 111, 16852-16857.

Kanglin Wang, Xin Qiu, Chaoqing Dong, Jicun Ren*, Single molecule technology for rapid detection of DNA hybridization based on resonance light scattering of gold nanoparticles as probes, ChemBioChem., 2007, 8, 1126-1129.

Chaoqing Dong, Jicun Ren*, On-line investigation of laser-induced aggregation and photo-activation of CdTe quantum dots by fluorescence correlation spectroscopy, J. Phys. Chem. C, 2007, 111, 7918-7923.

Hua He, Huifeng Qian, Chaoqing Dong, Kanglin Wang，Jicun Ren*, Single Nonblinking CdTe Quantum Dots Synthesized in Aqueous Thiopropionic Acid, Angew. Chem. Int. Ed. 2006, 45, 7588-7591.

Xiangyi Huang, Liang Li, Huifeng Qian, Chaoqing Dong, Jicun Ren* A Resonance Energy Transfer between Chemiluminescence Donors and CdTe Quantum Dots Acceptors (CRET), Angew. Chem. Int. Ed., 2006, 45, 5140-5143.

Chaoqing Dong, Huifeng Qian, Nenghu Fang and Jicun Ren*, Study of Fluorescence Quenching and Dialysis Process of CdTe Quantum Dot Using Ensemble Techniques and Fluorescence Correlation Spectroscopy, J. Phys. Chem. B, 2006, 110,11069-11075.

Huifeng Qian, Xing Qiu, Liang Li, Jicun Ren* Microwave assisted aqueous synthesis: a rapid approach to prepare highly luminescent ZnSe(S) alloyed quantum dots, J. Phys. Chem. B, 2006, 110, 9034-9040.

Jifang Weng, Jicun Ren*, Luminescent Quantum Dots: An Attractive Promising Tool in Biomedicine, Current Medicinal Chemistry, 2006, 13, 897-909.

Huifeng Qian, Jicun Ren*, Facile one-pot synthesis of highly luminescent, water-soluble and bio-compatible glutathione coated CdTe quantum Dots in aqueous phase, Small, 2006, 2,747-751.

Xiangyi Huang, Jicun Ren*, Chemiluminescence detection in capillary electrophoresis and microchip capillary electrophoresis, TRAC：Trends in Analytical Chemistry, 2006, 25,155-156.

Chaoqing Dong, Rui Bi, Huifeng Qian, Jicun Ren* Coupling fluorescence correlation Spectroscopy with Microchip Electrophoresis to Determine Effective Surface Charge of Water-Soluble QDs, Small, 2006, 2,534-538.

Liang Li, Huifeng Qian, Jicun Ren*，CdTe@Co(OH)(core/shell) nanoparticles: aqueous synthesis and characterizations, Chemical Communication,2005, 4083-4085.

Liang Li, Huifeng Qian, Jicun Ren*, Rapid Synthesis of Highly Luminescent CdTe Nanocrystals in Aqueous Phase by Microwave Irradiation with Controllable Temperature, Chemical Communication, 2005, 528-530.

Jicun Ren*, Arve Ulvik, Helga Refsum, Per Magne Ueland , Uracil in Human DNA from Subjects with Normal and Impaired Folate Status, as Determined by High Performance Liquid Chromatography-Tandem Mass, Analytical Chemistry, 2002, 74, 295-299.

Jicun Ren*, Xiangyi Huang, Highly Sensitive and Universal Indirect Chemiluminescence Detection for Capillary Electrophoresis of Cations Using Cobalt(II) As A Novel Probe Ion, Analytical Chemistry, 2001, 73, 2663-2668.

专著
Jicun Ren, 《Capillary Electrophoresis of Nucleic Acid》, Chapter 10 and Chapter 19, Jan., 2001, Humana Press Inc., Totowa, NJ, USA.

10. 其他
竭诚欢迎报考（或推免）本实验室硕士、博士研究生和从事博士后研究！具有有机合成、分子生物学和细胞生物学背景优先。