招生简介致考生书招生院系与专业导师介绍参考书籍联系方式信息公告
葛盛芳

导师姓名
葛盛芳
研究方向疾病分子生物学基础及其基因治疗
联系方式通讯地址：上海市制造局路639号

邮政编码：200011

联系电话：631356

Email：geshengfang@hotmail.com
个人简介

欢迎报考和免推！联系方式：geshengfang@hotmail.com主要研究方向:疾病分子生物学基础及其基因治疗(1)肿瘤的分子生物学基础（针对恶性肿瘤发生、发展的分子机制进行的基础研究，如癌基因和抑癌基因等的活化和失活；细胞增殖、细胞周期、细胞凋亡等过程的调控；肿瘤药物作用靶点；肿瘤代谢变化等）；(2)肿瘤基因治疗（以腺病毒为载体的肿瘤基因治疗。前期参与开发研究的“重组人5型腺病毒（H101）注射液”已于2005年被国家食品药品监督管理局批准作为治疗肿瘤的药物上市。近年来，试图通过小干扰RNA，放疗，化疗，重离子等手段，提高腺病毒药物的疗效）。（3）疾病病因分析[RB和UM等肿瘤、睑裂狭小综合征(BPES)、神经纤维瘤等疾病突变位点筛选和发病机制研究]。mypublications:http://lib.bioinfo.pl/user:102473/pmid/uidmyinformation:http://daoshi.shsmu.edu.cn/teacherInfo.jsp?code=M7000341
代表性论著
1、WangH,SongX,ZhangH,ZhangJ,ShenX,ZhouY,FanX,DaiL,QianG,HoffmanAR,HuJF,GeS[葛盛芳(通讯作者)].Potentiationoftumorradiotherapybyaradiation-inducibleoncolyticandoncoapoptoticadenovirusincervicalcancerxenografts.IntJCancer(IF5.444),2012;15;130(2):443-532、YaoY,WangL,ZhangH,WangH,ZhaoX,ZhangY,ZhangL,FanX,QianG,HuJ,GeS(通讯作者).ANovelAnticancerTherapyThatSimultaneouslyTargetsAberrantp53andNotchActivitiesinTumors.PLoSONE,2012;7(10):466273、WangZ,JiaR,GeS(葛盛芳),HeT,ZhangY,YangY,WangY,ShiW,JiY,YeF,ChenP,LuJ,SunJ,XuX,ZhouY,GuP,LuoM,LuH,FanX.OcularComplicationsofHumanImmunodeficiencyVirusInfectioninEasternChina.AmJOphthalmol(IF4.239),2012;153(2):363-3694、ZhangJ,SunQ,ZhangZ,GeS[葛盛芳],HanZG,ChenWT.LossofmicroRNA-143/145disturbscellulargrowthandapoptosisofhumanepithelialcancersbyimpairingtheMDM2-p53feedbackloop.Oncogene(IF7.414),2012;0(0):01-85、HuangX,JiaR,ZhaoX,LiuB,WangH,WangJ,ZhouY,CunB,GeS(通讯作者),FanX..RecombinantoncolyticadenovirusH101combinedwithsiBCL2:cytotoxiceffectonuvealmelanomacelllines.BrJOphthalmol,2012Jul27;96(10):1331-86、ZhangJ,GuoH,ZhangH,WangH,QianG,FanX,HoffmanAR,HuJF,GeS[葛盛芳(通讯作者)]#.PutativetumorsuppressormiR-145inhibitscoloncancercellgrowthbytargetingoncogeneFriendleukemiavirusintegration1..Cancer(IF5.131),2011;117(1):86-957、ZhangH,NiuB,HuJF,GeS（葛盛芳）,WangH,LiT,LingJ,SteelmanBN,QianG,HoffmanAR..InterruptionofintrachromosomalloopingbyCTCFdecoyproteinsabrogatesgenomicimprintingofhumaninsulin-likegrowthfactorII.JournalofCellbiology(IF10.264),2011;193(3):475-878、XuH,NiP,ChenC,YaoY,ZhaoX,QianG,FanX,GeS[葛盛芳(通讯作者)].SP1suppressesphorbol12-myristate13-acetateinducedup-regulationofhumanregucalcinexpressioninlivercancercells..MolCellBiochem,2011;355(1):9-159、ZhangJ,HuangS,ZhangH,WangH,GuoH,QianG,FanX,LuJ,HoffmanAR,HuJF,GeS[葛盛芳(通讯作者)].TargetedknockdownofBcl2intumorcellsusingasyntheticTRAIL3’-UTRmicroRNA..IntJCancer(IF5.444).,2010;126(9):2229-223910、ZhouY,SongX,JiaR,WangH,DaiL,XuX,GuP,GeS[葛盛芳(通讯作者之一)],FanX.Radiation-induciblehumantumornecrosisfactor-relatedapoptosisinducingligand(TRAIL)genetherapy：anoveltreatmentforradioresistantuvealmelanoma..PigmentCell&MelanomaResearch(IF5.059),2010;23:661-67411、ZhangP,YingL,XuR,GeS[葛盛芳(通讯作者之一)],MeiW,LiF,DaiB,LuJ,QianG.Tumor-Specific,Hypoxia-RegulatedWWOXExpressionAdenovirusInhibitsHumanNon-SmallCellLungCancerGrowthinVivo..HumanGeneTherapy(IF4.829).,2010;21(1):27-3912、HuangX,WangL,ZhangH,WangH,ZhaoX,QianG,HuJ,GeS(通讯作者),FanX.Therapeuticefficacybytargetingcorrectionofnotch1-inducedaberrantsinuvealtumors.PLoSONE(IF4.537),2012;7(8):4430113、ZhangJ,GuoH,QianG,GeS,JiH,HuX,ChenW..MiR-145,anewregulatoroftheDNAFragmentationFactor-45(DFF45)-mediatedapoptoticnetwork.MolCancer(IF4.16),2010;9(1):211-22014、ZhangH,WangH,ZhangJ,QianG,NiuB,FanX,LuJ,HoffmanAR,HuJF,GeS[葛盛芳(通讯作者)].EnhancedTherapeuticEfficacybySimultaneouslyTargetingTwoGeneticDefectsinTumors..MolTher(IF7.149).,2009;17(1):57-64