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上海交通大学医学院研究生导师简介 韩泽广

上海交通大学 免费考研网/2013-01-10

基本信息
导师姓名: 韩泽广 专业代码: 071007
性别: 专业名称: 遗传学
培养单位: 瑞金医院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: hanzg@chgc.sh.cn 上海市张江高科技园郭守敬路351号1号楼401室
研究方向 (点击浏览详细信息)
肿瘤(肝癌)发病机制
重要功能基因研究
社会任职
《科学通报》特约编辑
World Journal of Gastroenterology编委
BMC Bioinformatics杂志Associate Editors(副主编)
ISRN Tropical Medicine杂志编委
The scientific world journal杂志(Genetics)编委
THE OPEN PARASITOLOGY JOURNAL(Editorial Advisory Board)
The Open Systems Biology Journal (Editorial Advisory Board)
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
81272271LZP介导的肝脏脂质代谢在肿瘤发生发展的作用及其分子机制研究国家自然科学基金2013-01~~2016-1270万元课题负责人
2013ZX10002010-006基于肝癌组织外显子组突变检测的分子分型与DLK1丰度检测试剂盒研制卫生部重大专项2013-01~~2015-12196.03万元子课题负责人
2012ZX10002012-008肝癌转移相关分子标志物和治疗靶标筛选和验证卫生部重大专项2012-01~~2015-12331.77万元子课题负责人
81071722SCARA5在肝癌发生和转移过程中的作用及分子机制研究国家自然科学基金2011-01~~2014-1232万元课题负责人
2010CB529200基于系统生物医学基础的白血病临床转化研究(首席科学家)973计划项目2010-01~~2014-123000万元主要责任人
2008ZX10002-021病毒性肝炎相关肝癌转移复发的分子标志预测与干预新策略研究国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项课题2008-10~~2010-12270.355万元子课题负责人
2008ZX10002-020病毒性相关肝癌发生发展的分子网络调控机制与干预位点研究国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项课题2008-10~~2010-12820.25万元子课题负责人
20072901200肝癌表观遗传学异常与转录组改变和临床特性的关联研究国际科技合作与交流专项2008-01~~2010-12100万元主要责任人
学术论文 (#为通讯作者,*为共同第一作者)

1、Han ZG.. Functional Genomic Studies: Insights into the Pathogenesis of Liver Cancer.. Annu Rev Genomics Hum Genet,2012;13:171-205
2、Huang J, Deng Q, Wang Q, Li KY, Dai JH, Li N, Zhu ZD, Zhou B, Liu XY, Liu RF, Fei QL, Chen H, Cai B, Zhou B, Xiao HS, Qin LX, Han ZG.#. Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma.. Nature Genetics,2012;44(10):1117-1121
3、Yan B, Zhang ZZ, Huang LY, Shen HL, Han ZG.#. OIT3 deficiency impairs uric acid reabsorption in renal tubule. FEBS Lett.,2012;586(6):760-5
4、Xu X, Liu RF, Zhang X, Huang LY, Chen F, Fei QL, Han ZG.#. DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma.. Mol Cancer Ther.,2012;11(3):629-38
5、Cheng N, Li Y, Han ZG. #. Ago2 promotes tumor metastasis via upregulating FAK expression in hepatocellular carcinoma. Hepatology,2012;2012 Dec 19. doi: 10.1002/hep.26202. [Ep
6、Wang H, Wu K, Sun Y, Li Y, Wu M, Qiao Q, Wei Y, Han ZG#, Cai B. . STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro. . BMB Rep.,2012;45(11):629-34
7、Wei YJ, Hu QQ, Gu CY, Wang YP, Han ZG#, Cai B. . Up-regulation of NICE-3 as a Novel EDC Gene Could Contribute to Human Hepatocellular Carcinoma.. Asian Pac J Cancer Prev.,2012;2012;13(9):4363-8.
8、Wang H, Li Y, Wang Y, Han ZG#, Cai B. . C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma.. Mol Med Report.,2012;5(5):1169-74
9、Liu RF, Xu X, Huang J, Fei QL, Chen F, Li YD, Han ZG. #. Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. . Cancer Lett.,2012;2012 Nov 7. doi:pii: S0304-3835(12)00632
10、Stefanska B, Huang J, Bhattacharyya B, Suderman M, Hallett M, Han ZG#, Szyf M.. Definition of the landscape of promoter DNA hypomethylation in liver cancer.. Cancer Res.,2011;71(17):5891-903
11、Xu X, Liu RF, Wan BB, Xing WM, Huang J, Han ZG.#. Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines.. Mol Cell Biochem,2011;354(1-2):11-20
12、Wang KS, Chen G, Shen HL, Li TT, Chen F, Wang QW, Wang ZQ, Han ZG, Zhang X. . Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination. . PLoS One,2011;6(8):e23571.
13、Fu Y, Huang J, Wang KS, Zhang X, Han ZG. #. RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells. . Mol Biol Rep,2011;38(2):693-702
14、Deng Q, Wang Q, Zong WY, Zheng DL, Wen YX, Wang KS, Teng XM, Zhang X, Huang J, Han ZG.#. E2F8 Contributes to Human Hepatocellular Carcinoma via Regulating Cell Proliferation.. Cancer Res,2010;70(2):782-791
15、Huang J, Zheng DL, Qin FS, Cheng N, Chen H, Wan BB, Wang YP, Xiao HS, Han ZG.#. Genetic and epigenetic silencing of SCARA5 may contribute to hepatocellular carcinoma by activating FAK signaling. J Clin Invest.,2010;120(1):223-241
16、Han ZG. Epigenetic analysis in the search for tumor suppressor genes.. Epigenomics,2010;2(4):489-493
17、Han ZG. Systems biomedical analysis of Schistosoma japonicum. . Frontiers of Medicine in China,2010;4(2):157-165
18、Huang J, Pei Hao, Hui Chen, Wei Hu, Qing Yan, Feng Liu, ZG Han#. Genome-wide identification of Schistosoma japonicum microRNAs using a deep sequencing approach. PLoS One,2009;4(12): e8206
19、Wang ZQ, Xing WM, Fan HH, Wang KS, Zhang HK, Wang QW, Qi J, Yang HM, Yang J, Ren YN, Cui SJ, Zhang X, Liu F, Lin DH, Wang WH, Hoffmann MK, Han ZG.#. The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function.. J Immunol,2009;183(10):6646-6656
20、Han ZG#, Brindley PJ, Wang SY, Chen Z.. Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction. Annu Rev Genomics Hum Genet,2009;10:211-240
21、The Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium.#. The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature,2009;460:345-351
22、Liu F, Cui SJ, Hu W, Feng Z, Wang ZQ, Han ZG.#. Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum. Mol Cell Proteomics.,2009; 8(6):1236-1251
23、Zheng DL, Zhang L, Cheng N, Xu X, Deng Q, Teng XM, Wang KS, Zhang X, Huang J, Han ZG.#. Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A.. J Hepatol,2009;50(2):377-387
24、Huang J, Lin Y, Li L, Qing D, Teng XM, Zhang YL, Hu X, Hu Y, Yang P, Han ZG.#. ARHI, as a novel suppressor of cell growth and downregulated in human hepatocellular carcinoma, could contribute to hepatocarcinogenesis.. Mol Carcinog.,2009;48(2):130-140
25、Ma Y, Qi X, Du J, Song S, Feng D, Qi J, Zhu Z, Zhang X, Xiao H, Han Z#, Hao X. Identification of candidate genes for human pituitary development by EST analysis. BMC Genomics.,2009;10:109


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