上海交通大学医学院研究生导师简介陈竺

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上海交通大学免费考研网/2013-01-10

基本信息

导师姓名:	陈竺	专业代码:	100201
性别:	男	专业名称:	内科学
培养单位:	瑞金医院	三级学科/ 专业领域:	血液病
导师类型:	博士生导师	专业学位导师:	兼
联系方式:	zchen@stn.sh.cn 上海市瑞金二路197号瑞金医院上海血液学研究所邮编：200025

研究方向 (点击浏览详细信息)

白血病治疗的细胞和分子机制研究

社会任职

中国病理生理学会实验血液学第6届专业委员会主任委员

中华医学会会长

科研项目

项目编号	项目名称	课题来源	起止时间	科研经费	承担职责
90809003	硫化砷、丹参酮IIA及靛玉红对急性早幼粒白血病细胞的诱导分化作用及其机制研究	国家自然基金委,面上项目	2008-01~~2008-12	21万元	null
20060248069	运用小鼠和斑马鱼进行组蛋白H3-K36甲基转移酶HYPB基因的表观遗传学功能研究	国家教育部,博士点基金	2007-01~~2009-12	6万元	null
20050266017	白血病发病相关蛋白MLL-EEN靶基因的研究	国家教育部,博士点基金	2006-01~~2008-12	6.5万元	null
30571046	累及NUP98新的染色体易位t(3;11)基因的克隆和功能研究	国家自然基金委,面上项目	2006-01~~2008-12	25万元	null
2004CB518600	多基因复杂性状疾病的系统生物学研究	国家科技部,973项目	2004-09~~2009-08	3000万元	null
04dz14004	利用系统生物学理念及方法动态性地研究恶性肿瘤发生及靶向治疗的分子网络	上海市科委,重大基础研究	2004-09~~2007-07	300万元	null

学术论文 (#为通讯作者,*为共同第一作者)

1、Hu M, Sun XJ, Zhang YL, Kuang Y, Wu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z.#. Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.. Proc Natl Acad Sci USA,2010;107:2956-2961.
2、Zhang XW, Yan XJ, Yang FF, Zhou ZR, Wu ZY, Sun HB, Liang WX, Song AX, Huang QH, Zhou GB, Tong JH, Zhang Y, Wu JH, Hu HY, Chen SJ, Chen Z. #. Arsenic trioxide controls the fate of the PML-RAR? oncoprotein by directly binding PML. . Science,2010;329: 240-243.
3、Zhang QY, Mao JH, Liu P, Huang QH, Lu J, Xie YY, Weng L, Zhang Y, Chen Q, Chen SJ, Chen Z. #. A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL associated leukemia. . Proc Natl Acad Sci USA,2009;106: 3378-3383.
4、Liu F, Zhou Y, Wang ZQ, Lu G, Zheng H, Brindley PJ, McManus DP, Blair D, Zhang QH, Zhong Y, Wang S, Han ZG, Chen Z. #. The Schistosoma japonicum genome reveals features of host-parasite interplay. . Nature,2009;460:345-351.
5、Hu J, Liu YF, Wu CF, Xu F, Shi ZX, Zhu YM, Li JM, Tang W, Zhao WL, Wu W, Sun HP, Chen QS, Chen B, Zhou GB, Zelent A, Waxman S, Wang ZY, Chen SJ, Chen Z. #. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide based therapy in newly diagnosed acute promyelocytic leukemia. . Proc Natl Acad Sci USA,2009;106: 3342-3347.
6、Hu J, Liu YF, Wu CF, Xu F, Shi ZX, Zhu YM, Li JM, Tang W, Zhao WL, Wu W, Sun HP, Chen QS, Chen B, Zhou GB, Zelent A, Waxman S, Wang ZY, Chen SJ, Chen Z. #. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide based therapy in newly diagnosed acute promyelocytic leukemia. . Proc Natl Acad Sci USA,2009;106: 3342-3347.
7、Wang ZY, Chen Z. #. Acute promyelocytic leukemia: from highly fatal to highly curable. . Blood,2008;111:2505-2515.
8、Wang L, Zhou GB, Liu P, Song JH, Liang Y, Yang XJ, Xu F, Wang BS, Mao JH, Shen ZY, Chen SJ, Chen Z. #. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. . Proc Natl Acid Sci USA,2008;;105: 4826-4831.
9、Zhou GB, Kang H, Wang L, Gao L, Liu P, Xie J, Zhang FX, Weng XQ, Shen ZX, Chen J, Gu LJ, Yan M, Zhang DE, Chen SJ, Wang ZY, Chen Z. #. Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo. . Blood,2007;109:3441-3450.
10、Zhou GB, Zhao WL, Wang ZY, Chen SJ, Chen Z. #. Retinoic acid and arsenic for treating acute promyelocytic leukemia. . PloS Medicine,2005;2:33-38.
11、Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z. #. Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. . JBC,2005;280:35261-35271.
12、Song HD, Sun XJ, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y, Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT, Chen Z. . Hematopoietic Gene Expression Profile in Zebrafish Kidney Marrow. . Proc Natl Acad Sci USA,2004;101:16240-16245