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上海交通大学医学院研究生导师简介 刘炳亚

上海交通大学 免费考研网/2013-01-10

基本信息
导师姓名: 刘炳亚 专业代码: 100210
性别: 专业名称: 外科学
培养单位: 瑞金医院 三级学科/
专业领域:
普外
导师类型: 博士生导师 专业学位导师:
联系方式: liubyrj@yahoo.com.cn 上海市瑞金二路197号\200025\64670644
研究方向 (点击浏览详细信息)
胃肠肿瘤发生发展分子机制及综合治疗的基础研究
社会任职
国际胃癌学会(IGCA)会员
国际肿瘤细胞基因治疗学会(ISCGTC)会员
中国抗癌协会胃癌专业委员会副主任委员
上海市抗癌协会理事
上海市抗癌协会胃肠肿瘤专业委员会委员
中华胃肠外科杂志编委
中华医学会上海分会外科专科委员会常务委员
外科理论与实践杂志编委
世界华人消化杂志编委
中国普通外科杂志编委
美国癌症研究学会(AACR)会员
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
91229106慢性胃炎向胃癌转化的转录调控网络及其关键节点的研究国家自然基金(重大研究计划)2013-01~~2016-1290万元课题负责人
12XD1403700胃癌功能性抗原的鉴定及生物学功能和分子机制的研究市科委(优秀学术带头人)2012-07~~2012-0640万元课题负责人
81172324mir-409-3p对PHF10表达失调促进胃癌进展及其分子机制研究国家自然科学基金2012-01~~2015-1253万元课题负责人
2011BA203191基于分子标志物的胃癌早期诊断、分子分型科技部国家支撑计划2012-01~~2016-12500万元课题负责人
20110073110071miR-409-3p对PHF10表达失调促进胃癌进展及其分子机制研究教育部博士点基金(博导类)2012-01~~2014-1212万元课题负责人
30872476肿瘤相关成纤维细胞中TAGLN在胃癌转移中的作用及其分子机制研究国家自然基金委,面上项目2009-01~~2011-1234万元课题负责人
2008BAI52B03胃癌预警指标体系研究与预警模型的开发国家支撑计划2008-09~~2011-12160万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Zhang BG, Li JF, Yu BQ, Zhu ZG, Liu BY*#, Yan M.. microRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN.. Oncol Rep.,2012;27(4):1019-26.
2、Li CL, Nie H, Wang M, Su LP, Li JF, Yu YY, Yan M, Qu QL, Zhu ZG, Liu BY.#. microRNA-21 promotes tumor microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis.. Oncol Rep.,2012;27(6):1960-6.
3、Yu BQ, Su LP, Li JF, Cai Q, Yan M, Chen XH, Yu YY, Gu QL, Zhu ZG, Liu BY.#. microrna expression signature of gastric cancer cells relative to normal gastric mucosa. Mol Med Report.,2012;6(4):821-6.
4、Wang M, Li C, Nie H, Lv X, Qu Y, Yu B, Su L, Li J, Chen X, Ju J, Yu Y, Yan M, Gu Q, Zhu Z, Liu B.#. Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK.. FEBS Lett.,2012;586(16):2382-8.
5、Chen L, Su L, Li J, Zheng Y, Yu B, Yu Y, Yan M, Gu Q, Zhu Z, Liu B.#. Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer.. Dis Markers.,2012;32(3):195-202.
6、Li CL, Nie H, Wang M, Su L, Li J, Yu B, Wei M, Ju J, Yu Y, Yan M, Gu Q, Zhu Z, Liu B.#. MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer.. Cancer Lett.,2012;320(2):189-97.
7、Li C, Li JF, Cai Q, Qiu QQ, Yan M, Liu BY#, Zhu ZG.. MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer.. Ann Surg Oncol.,2012;Sep 7.
8、Wei M#, Wang Z, Yao H, Yang Z, Zhang Q, Liu B, Yu Y, Su L, Zhu Z, Gu Q.. P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells.. BMC Cancer.,2011;11:109-120.
9、Wei M#, Zhu L, Li Y, Chen W, Han B, Wang Z, He J, Yao H, Yang Z, Zhang Q, Liu B, Gu Q, Zhu Z, Shen K.. Knocking down cyclin D1b inhibits breast cancer cell growth and suppresses tumor development in a breast cancer model.. Cancer Sci,2011;102(8):1537-44.
10、Ke-Feng Lei#, Bing-Ya Liu, Xiao-Qing Zhang, Xiao-Long Jin, Yan Guo, Min Ye, Zheng-Gang Zhu.. Development of a survival prediction model for gastric cancer using serine proteases and their inhibitors.. Expreimental and Therapeutic Medicine,2011;9:21-27
11、Chen L#, Lan B, Chen XH, Li JF, Qu Y, Yu BQ, Yu YY, Gu QL, Zhu ZG, Liu BY.. Cell cycle dependent genes from the gastric cancer cell MKN45 can affect tumorigenesis.. Hepatogastroenterology.,2011;58(106):674-81.
12、Lei KF#, Liu BY, Wang YF, Chen XH, Yu BQ, Guo Y, Zhu ZG.. SerpinB5 interacts with KHDRBS3 and FBXO32 in gastric cancer cells.. Oncol Rep.,2011;26(5):1115-20.
13、Qu Y, Wang J, Sim MS, Liu B*, Giuliano A, Barsoum J, Cui X.. Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells. Breast Cancer Res Treat,2010;121(2):311-21.
14、Feng RH#, Chen XH, Yu YY, Su LP, Yu BQ, Li JF, Cai Q, Yan M, Liu BY, Zhu ZG.. miR-126 functions as a tumour suppressor in human gastric cancer.. Cancer Letters,2010;298:50-63.
15、Ke S#, Chen XH, Zhu ZG, Li JF, Yu BQ, Gu QL, Liu BY.. Silencing invariant chains of dendritic cells enhances anti-tumor immunity using small-interfering RNA.. Chin Med J (Engl).,2010;123(22):3193-9.
16、Zheng Z#, Li JF, He XY, Chen XH, Yu BQ, Zhang JN, Wang TF, Gu QL, Zhu ZG, Liu BY. Involvement of RhoGDI2 in the resistance of colon cancer cells to 5-fluorouracil. Hepatogastroenterology,2010;57(102-103):1106-12.
17、Wu B#, Yin TT, Cao W, Gu ZD, Wang X, Yan M, Liu B. Validation of the Chinese version of the Subjective Global Assessment scale of nutritional status in a sample of patients with gastrointestinal cancer. Int J Nurs Stud,2010;47(3):323-31
18、Guo X#, Liu W, Pan Y, Ni P, Ji J, Guo L, Zhang J, Wu J, Jiang J, Cheng X, Cai Q, Li J, Zhang J, Gu Q, Liu B, Zhu Z, Yu Y.. Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma. Oncogene,2010;29(27):3908-20
19、Qu Y, Li JF, Cai Q, Wang YW, Gu QL, Zhu ZG, Liu BY.*#. Over-expression of FRZB in gastric cancer cell suppresses proliferation and induces diVerentiation.. J Cancer Res Clin Oncol,2008;134(3):353-364
20、Qin JM, Gu QL, Yan M, Zhu ZG, Liu BY *.#. Comparative proteomics analysis of human gastric cancer. World J Gastroenterol. World J Gastroenterol,2008;14(37): 5657-5664
21、Wang F, Xia P, Wu F, Wang D, Wang W, Ward T, Liu Y*, Aikhionbare F, Guo Z, Powell M, Liu B, Bi F, Shaw A, Zhu Z, Elmoselhi A, Fan D, Cover TL, Ding X, Yao X. Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells. J Biol Chem,2008;283(39):26714-25
22、Wang F, Xia P, Wu F, Wang D, Wang W, Ward T, Liu Y*, Aikhionbare F, Guo Z, Powell M, Liu B, Bi F, Shaw A, Zhu Z, Elmoselhi A, Fan D, Cover TL, Ding X, Yao X. Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells. J Biol Chem,2008;283(39):26714-25
23、Ye Q, Zheng MH, Cai Q, Feng B, Chen XH, Yu BQ*, Gao YB, Ji J, Lu AG, Li JW, Wang ML, Liu BY. PKA-mediated protein phosphorylation protects ezrin from calpain I cleavage. Cancer Sci.,2008;99(10):1924-32
24、Liu W, Liu B*, Xin L, Zhang Y, Chen X, Zhu Z, Lin Y. Down-regulated expression of complement factor I: A potential suppressive protein for gastric cancer identified by serum proteome analysis. Clin Chim Acta,2007;377(1-2):119-26
25、Xin L, Cao WX, Fei XF, Wang Y, Liu WT, Liu BY*, Zhu ZG. Applying proteomic methodologies to analyze the effect of methionine restriction on proliferation of human gastric cancer SGC7901 cells. Clin Chim Acta,2007;377(1-2):206-12
26、Ke S, Chen XH, Li H, Li JF, Gu QL, Liu BY*, Zhu ZG. Silencing invariant chain of DCs enhances Th1 response using small interfering RNA. Cell Biol Inter,2007;31(0): 663-671
27、 Shen WW, Wu J, Cai L, Liu BY*, Gao Y, Chen GQ, Fu GH. Expression of Anion Exchanger 1 Sequestrates p16 in the Cytoplasm in Gastric and Colonic Adenocarcinoma1. Neoplasia,2007;9(10): 812 – 819
28、Gu QL, Huang X, Ren WH, Shen L, Liu BY*, Chen SY. Targeting hepatitis B virus antigens to dendritic cells by heat shock protein to improve DNA vaccine potency.. World J Gastroenterol,2007;13(44):5911-7
29、 Hao JH, Gu QL, Liu BY*, Li JF, Chen XH, Ji YB, Zhu ZG, Lin YZ. Inhibition of the proliferation of human gastric cancer cells SGC-7901 in vitro and in vivo using Bcl-2 siRNA. Chin Med J (Engl),2007;120(23):2105-11
30、Chen XH, Lan B, Qu Y, Zhang XQ, Cai Q, Liu BY*#, Zhu ZG. Inhibitory effect of Polo-like kinase 1 depletion on mitosis and apoptosis of gastric cancer cells. World J Gastroenterol. World J Gastroenterol,2006;12(1): 29-35
31、Wang YW, Qu Y, Li JF, Chen XH, Liu BY*, Gu QL, Zhu ZG. In vitro and In vivo Evidence of Metallopanstimulin-1 in Gastric Cancer Progression and Tumorigenicity. Clin Cancer Res,2006;12(16) :4965-4973
32、Wang F, Xia P, Wu F, Wang D, Wang W, Ward T*, Liu Y, Aikhionbare F, Guo Z, Powell M, Liu B, Bi F, Shaw A, Zhu Z, Wang H, Guo Z, Wu F, Long F, Cao X, Liu B, Zhu Z, Yao X. PKA-mediated protein phosphorylation protects ezrin from calpain I cleavage. Biochem Biophys Res Commun,2005;333(2):496-501


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