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上海交通大学医学院研究生导师简介 房静远

上海交通大学 免费考研网/2013-01-10

基本信息
导师姓名: 房静远 专业代码: 100201
性别: 专业名称: 内科学
培养单位: 仁济医院 三级学科/
专业领域:
消化系病
导师类型: 博士生导师 专业学位导师:
联系方式: jingyuanfang@yahoo.com 上海市山东中路145号仁济医院综合楼917室邮编:200001 电话:021-53882450
研究方向 (点击浏览详细信息)
消化系肿瘤发生的分子机制、早期诊断和综合防治
社会任职
上海市消化疾病研究所所长
上海交通大学医学院附属仁济医院消化科主任
上海市消化内科临床质量控制中心主任
上海市重中之重消化内科临床医学中心主任
卫生部内科消化重点实验室主任
国务院学位委员会学科评议组成员
中华医学会消化病学分会常委兼秘书和肿瘤协作组组长
中国医师协会消化医师分会执行常委
上海市消化学会副主任委员
上海交通大学医学院学报副主编
胃肠病学杂志常务副主编
中华医学杂志编委
中华消化杂志编委
中华消化内镜杂志编委
中华内科杂志编委
中华胰腺病杂志编委
上海交通大学医学院教授委员会副主任
上海交通大学医学院附属仁济医院学术委员会副主任委员
上海交通大学学术委员会委员
上海交通大学学位委员会委员
上海交通大学医学院学位委员会委员
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
2012AA02A504胃癌分子分型和个体化诊疗技术863课题2012-01~~2015-12110万元课题负责人
表观遗传修饰和信号通路与胃肠肿瘤的发生和预防教育部创新团队2012-01~~2015-1230万元课题负责人
30971330天然反义RNA在胃癌发生发展中的重要调控作用国家自然基金面上项目2010-01~~2012-1231万元课题负责人
2010CB5293胃癌新标志物的筛选及其预警和早诊作用的大规模人群研究973项目子课题2010-01~~2014-12170万元子课题负责人
30921140311胃癌变过程的表观遗传学特征国家自然基金国际合作项目2010-01~~2012-1230万元子课题负责人
20090073110077PcG蛋白在大肠癌中表达的临床意义及其与ERK通路的关系教育部博士点基金2010-01~~2012-126万元主要责任人
表观遗传修饰与消化系肿瘤上海市高校创新团队2009-01~~2011-12150万元课题负责人
PCNA介导ERK-MAPK信号通路影响人CRCDNA甲基化教育部博士点基金2009-01~~2011-126万元主要责任人
30830055大肠癌发生中ERK-MAPK信号通路与DNA甲基化网络关系及其机制研究国家自然基金委,重点项目2009-01~~2012-12170万元课题负责人
2008ZX09312-007新药临床研究技术平台建设—抗慢性乙型病毒性肝炎新药临床评价研究平台的构筑国家十一五重大专项2008-01~~2010-12790万元课题负责人
200802094生物活性食物成分药物预防大肠癌的研究国家十一五卫生公益行业基金2008-01~~2011-12290万元课题负责人
消化系肿瘤的发生机制研究上海交通大学医学院优秀学科带头人计划2007-10~~2010-12150万元课题负责人
2006AA02A402胃癌分子分型和个体化治疗研究国家863重大专项子课题2007-01~~2010-1280万元课题负责人
30625034mTOR信号通路与表观遗传修饰在大肠癌发生中的网络调控国家自然基金委,杰出青年2007-01~~2010-12200万元课题负责人
20050266013人结直肠癌DNA甲基化与ERK-MAPK信号传导的作用国家教育部,博士点基金2006-01~~2008-126万元课题负责人
30470781胃癌发生中粘膜组织叶酸及其受体和代谢相关酶与DNA甲基化的关系国家自然基金面上项目2005-01~~2005-128万元课题负责人
2005CB522400肿瘤和神经系统疾病的表观遗传机制973课题2005-01~~2010-12120万元子课题负责人
2002AA27胃癌及癌前病变基因表达谱及标志基因的鉴定863重大专项子课题2003-01~~2004-1224万元子课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Du W, Hong J, Wang YC, Zhang YJ, Wang P, Su WY, Lin YW, Lu R, Zou W, Xiong H, Fang JY.#. MicroRNA 345, a methylation-sensitive Inhibition of JAK2/STAT3 signaling induces colorectal cancer cell apoptosis via mitochondrial pathway.. J Cell Mol Med,2012;16(8):1878-88
2、Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY#. Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer. . Cell Res,2012;doi:10.1038/cr.2012.57
3、Xiong H, Hong J, Du W, Lin YW, Ren LL, Wang YC, Su, Wang JL, Cui Y, Wang ZH, Fang JY#. Roles of STAT3 and ZEB1 in E-cadherin downregulation and human colorectal cancer epithelial-mesenchymal transition. J Biol Chem.,2012;287(8):5819-32
4、Xiong H, Du W, Wang JL, Wang YC, Hong J, Fang JY#. Constitutive activation of STAT3 is predictive of poor prognosis in human gastric cancer.. J Mol Med,2012;DOI 10.1007/s00109-012-0869-0
5、Du W, Wang YC, Su WY, Lin YW, Hong J, Lu R, Xiong H, Fang JY #. STAT5 isoforms play important role in colorectal cancer preferentially associated with STAT5b. . J Cell Physiol.,2012;227(6):2421-9
6、Weng YR, Cui Y, Fang JY #. Biological Functions of Cytokeratin 18 in Cancer.. Mol Cancer Res,2012;doi: 10.1158/1541-7786. MCR-11-0222
7、Wang P, Wang YC, Chen XY, Shen ZY, Cao H, Zhang YJ, Yu J,Zhu JD, Lu YY, Fang JY #. CTHRC1 is upregulated by promoter demethylation and TGF-β1 and may associated with metastasis in human gastric cancer. . Cancer Sci,2012;PMID:22590977
8、Xiong H, Du W, Zhang YJ, Hong J, Su WY, Tang JT, Wang YC, Lu R, Fang JY #. Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. . Mol Carcinog,2012;51(2):174-84
9、Chooi EYH, Chen HM, Shen L, Miao Q, Weng YR, Chen XY, Ge ZZ, Xiao SD, Fang JY#. Chronic atrophy gastritis is a progressive disease: An Analysis Reports in Shanghai, China from 1985 – 2009. Singapore Medical Journal,2012;53(5):318-24
10、Kong X, Wang JL, Chen HM, Fang JY#. Comparison of the clinicopathological characteristics of young and elderly patients with gastric carcinoma: a meta-analysis. J Surg Oncol,2012;106:346–352
11、Gao QY, Wang ZH, Hao EY, Chui Y, Hu Y, Yang CQ, Liu F, Zheng P, Wang CD, Song YY, Fang JY#. A novel model might predict the risk of chronic atrophic gastritis: a multicenter prospective study in China. Scand J Gastroenterol,2012;47(5):509-17
12、Wang ZH, Gao QY, Fang JY#. Loss of PTEN expression as a predictor for resistance to anti-EGFR monoclonal therapy in metastatic colorectal cancer: Evidence from retrospective studies. Cancer Chemotherapy and Pharmacology,2012;69(6):1647-55
13、Wang ZH, Gao QY, Fang JY#. Repeat screening colonoscopy every 10 years or single colonoscopy for colorectal neoplasm screening in average-risk Chinese: A cost-effectiveness analysis. Asian Pacific J Cancer Prev,2012;13: 1761-6
14、Fu L, Chen L, Yang J, Ye T, Chen Y, Fang JY. HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism. Carcinogenesis,2012;33: 1664-1673
15、Wang ZH, Gao QY, Fang JY#. Meta-analysis of the efficacy and safety of Lactobacillus and Bifidobacterium containing probiotic compound preparation in Helicobacter pylori eradication therapy. J Clin Gastroenterol,2012;PMID:23090045
16、Wang ZH, Gao QY, Fang JY#. Green tea and incidence of colorectal cancer: evidence from prospective cohort studies. Nutr and Cancer,2012;64(8):1143-1152
17、Du W, Wang S, Zhou Q, Li X, Chu J, Chang Z, Tao Q, Ng E, Fang JY#, Sung JJY, Yu J. ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer. Oncogene,2012;PMID: 22907434
18、Xue H, Wang YC, Lin B, An J, Chen L, Chen J, Fang JY#. A meta-analysis of interleukin-10 -592 promoter polymorphism associated with gastric cancer risk. PLoS One. .,2012;7(7):e39868
19、Tang JT, Wang JL, Hong J, Du W, Zhao SL, Wang YC, Xiong H, Chen HM, Fang JY#. MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer.. Carcinogenesis,2011; 32(8):1207-15
20、Wang JL, Lin YW, Chen HM, Kong X, Hong J, Fang JY#. Calcium prevents tumorigenesis in a mouse model of colorectal cancer. . PLoS One,2011;6(8):2256634
21、Zhao SL, Hong J, Xie ZQ, Tang JT, Su WY, Du W, Chen YX, Lu R, Sun DF, Fang JY#. TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells.. PLoS One,2011;6(8):e23262
22、Cui Y, Su WY, Xing J, Wang YC, Wang P, Chen XY, Shen ZY, Cao H, Lu YY, Fang JY #. MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer.. PLoS One,2011; 6(10):e25872
23、Lin YW, Chen HM, Fang JY #. Concise review in gene silencing by polycomb group protein system and connections to cancers.. Cancer Invest.,2011;29(3):187-95
24、Ge ZZ, Chen HM, Gao YJ, Liu WZ, Xu CH, Tan HH, Chen HY, Wei W, Fang JY, Xiao SD. . Efficacy of Thalidomide for Refractory Gastrointestinal Bleeding from Vascular Malformation. . Gastroenterology.,2011;141(5):1629-1637
25、Kryczek I, Wu K, Zhao E, Wei S, Vatan L, Szeliga W, Huang E, Greenson J, Chang A, Rolinski J, Radwan P, Fang J, Wang G, Zou W. . IL-17+ Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer.. J Immunol,2011;186(7):4388-95
26、Wilke CM, Wang L, Wei S, Kryczek I, Huang E, Kao J, Lin Y, Fang JY#, Zou W . Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel disease. . J Transl Med.,2011;9(1):217
27、Lin YW, Wang JL, Chen HM, Zhang YJ, Lu R, Ren LL, Hong J, Fang JY#. Folic Acid supplementary reduce the incidence of adenocarcinoma in a mouse model of colorectal cancer: microarray gene expression profile. Exp Clin Cancer Res.,2011;2011;30(1):116-7
28、Cui Y, Xue H, Lin B, Ni P, Fang JY#. A Meta-Analysis of CDH1 C-160A Genetic Polymorphism and Gastric Cancer Risk.. DNA Cell Biol,2011;30(11):937-45
29、Wang JL, Sun TT, Lin YW, Lu R, Fang JY#. Methodological reporting of randomized controlled trials in major hepato-gastroenterology journals in 2008 and 1998: a comparative study. BMC Med Res Methodol,2011;11(1):110-17
30、Sun TT, Wang JL, Fang JY#. Quality of RCTs exploring Helicobacter pylori eradication for the prevention of gastric cancer and preneoplastic lesions. Expert Rev Anticancer Ther,2011;11(10):1509-19
31、Lin YW, Wang JL, Chen HM, Zhang YJ, Lu R, Ren LL, Hong J, Fang JY #. Folic Acid supplementary reduce the incidence of adenocarcinoma in a mouse model of colorectal cancer: microarray gene expression profile. J Exp Clin Cancer Res,2011;30(1):116-23
32、Ren LL, Fang JY#. Should we sound the alarm? Dysplasia and colitis-associated colorectal cancer. Asian Pac J Cancer Prev,2011;12(8):1881-6
33、Su WY, Xiong H, Fang JY #. Natural antisense transcripts regulate gene expression in an epigenetic manner.. Biochem Biophys Res Commun.,2010;396(2):177-81
34、Du W, Li WY, Lu R, Fang JY#. Folate and fiber in the prevention Between shadows and the light. World J Gastroenterol,2010;16(8):921-926
35、Tang JT, Wang JL, Fang JY#. Meta-analysis: Perioperative regional liver chemotherapy for improving survival and preventing liver metastases in patients with colorectal carcinoma. J Dig Dis,2010;11(4):208-14
36、Wang P, Tang JT, Peng YS, Chen XY, Zhang YJ, Fang JY#. XRCC1 down-regulated through promoter hypermethylation is involved in human gastric carcingenesis. J Dig Dis,2010;11(6):343-51
37、Wang X, Sun DF, Lu R, Chen ZF, Chen YX, Fang JY#. RAF may induce cell proliferation through hypermethylation of tumor suppressor genes promoter in gastric epithelial cells.. Cancer Sci,2009;100(1):117-25
38、Xiong H, Zhang ZG, Liang QC, Tian XQ, Sun DF, Chen YX, Fang JY. #. Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells. . Lab Invest,2009;89(6):717-725
39、Xiong H, Chen ZF, Liang QC, Du W, Chen HM, Su WY, Han ZG, Chen GQ, Fang JY.#. Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signaling.. J Cell Mol Med,2009;13(9B):3668-79
40、Zhang YJ, Dai Q, Tian XQ, Xiong H, Gao FH, Sun DF, Xu MH, Chen GQc, Han ZG, Fang JY#. mTOR Signal Pathway is a Target for the Treatment of Colorectal Cancer. . Annals of Surgical Oncology,2009;16:2617-28
41、Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, Fang JY, Gao CM, G?tze T, Graziano F, Lacasa?a-Navarro M, Lin D, López-Carrillo L, Qiao YL, Shen H, Stolzenberg-Solomon R, Takezaki T, Weng YR, Zhang FF, van Duijn CM, Boffetta P, Taioli E.. Meta- and pooled analyses of the Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a HuGE-GSEC review. Am J Epid,2008;167(5):505-16
42、Xiong H, Zhang ZG, Tian XQ, Sun DF, Zhang YJ, Lu R, Liang QC, Chen YX, Fang JY. #. Inhibition of JAK1, JAK2 and STAT3 signaling induces apoptosis, cell cycle arrest and reduces tumor cell invasion in colorectal cancer cells. . Neoplasia,2008;10(3):287-97
43、Lu R, Wang X, Sun DF, Tian XQ, Zhao SL, Chen YX, Fang JY. #. Folic acid and sodium butyrate prevent tumorigenesis in a mouse model of colorectal cancer.. Epigenetics,2008;3(6):330-335
44、Gorelik G, Fang JY, Wu A, Sawalha AH, Richardson BC. Impaired T Cell Protein Kinase C{delta} Activation Decreases ERK Pathway Signaling in Idiopathic and Hydralazine-Induced Lupus.. J Immunol.,2007;179(8):5553-63
45、Lu R, Wang X, Chen ZF, Sun DF, Tian XQ, Fang JY#. Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decrease DNA methylation in colon cancer cells. . J Biol Chem,2007;282(16):12249-12259
46、Fang JY#, Lu R, Mikovits JA, Cheng ZH, Zhu HY, Chen YX,Lu LG. Recombinant DNA methyltransferase 1 constructs regulate expression of hMSH2 and hMLH1 in human colon cancer cell line SW1116. . Cancer Lett,2006;233(1):217-25
47、Fang JY#, Richardson BC. The MAPK signaling pathway and human colorectal cancer. . Lancet Oncology,2005;6(5):322-327
48、Fang JY#, Chen YX, Lu J, Lu R, Yang L, Zhu HY, Gu WQ, Lu LG. . Epigenetic modification regulates expression of tumor-associated genes and cell cycle in human colon cancer cell lines Colo-320 and SW1116.. Cell Res.,2004;13 (3):217-226
49、Flynn J,Fang JY,Mikovits JA, Reich NO.. A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase.. J Biol Chem.,2003;278(10): 8238-8243
50、Fang JY, Mikovits JA, Bagni R, Petrow-Sadowski CL, Ruscetti FW.. Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylation.. J Virol.,2001;75(20):9753-61


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