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上海交通大学医学院研究生导师简介 郝思国

上海交通大学 免费考研网/2013-01-10

基本信息
导师姓名: 郝思国 专业代码: 100201
性别: 专业名称: 内科学
培养单位: 新华医院 三级学科/
专业领域:
血液病
导师类型: 博士生导师 专业学位导师:
联系方式: haosghj88@hotmail.com 上海市杨浦区控江路1665号,上海交通大学医学院附属新华医院 血液科,邮编200090
研究方向 (点击浏览详细信息)
造血干细胞移植,恶性血液肿瘤的免疫治疗
社会任职
中华医学会上海市血液学分会委员
上海市血液学研究所副所长
中华造血干细胞库专家委员会委员
上海市脐带血库专家委员会委员
国家自然科学基金评审专家
Cancer Biotherapy and Radiopharmaceuticals评审专家
Clinical and experimental Immunology评审专家
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
81170527I型调节性T 细胞在防治造血干细胞移植中移植物抗宿主病作用的研究国家自然科学基金2012-01~~2015-1259万元主要责任人
81071857肿瘤细胞胞外体靶向结合的树突状细胞的生物学特性及其抗肿瘤免疫效应国家自然科学基金2011-01~~2013-1233万元主要责任人
20071312.白血病细胞胞外体在白血病免疫治疗中的应用研究。上海市卫生局2008-12~~2011-126万元主要责任人
白血病细胞胞外体的生物学特性教育部留学回国人员科研启动基金2008-12~~2011-123万元主要责任人
08PJ4076001.以白血病细胞胞外体为基础的白血病疫苗的研究。上海市科委浦江人才计划2008-08~~2010-1020万元主要责任人
81170527I型调节性T 细胞在防治造血干细胞移植中移植物抗宿主病作用的研究国家自然科学基金~~万元主要责任人
学术论文 (#为通讯作者,*为共同第一作者)

1、Hao S*, Yuan J, Xu S, Munegowda MA, Deng Y, Gordon J, Xing Z, Xiang J.. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. . The Journal of Immunology,2008;15;181(4):2428-37
2、2.Ye Z, Ahmed KA, Hao S*, Zhang X, Xie Y, Munegowda MA, Meng Q, Chibbar R, Xiang J. Active CD4+ helper T cells directly stimulate CD8+ cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet beta-cell ovalbumin antigen leading to diabetes. . Autoimmunity,2008;41(7):501-11
3、郝思国*,王椿. Exosome一个新型的潜在的抗肿瘤疫苗。. 细胞与分子免疫学杂志,2008;24:207-209
4、2.Ye Z, Ahmed KA, Hao S*, Zhang Ye Z, Huang H, Hao S, Xu S, Yu H, Van Den Hurk S, Xiang JChibbar R, Xiang J. IL-10 has a distinct immunoregulatory effect on naive and active T cell subsets.. J Interferon Cytokine Res.,2007;27(12):1031-8.
5、Hao S*, Liu Y, Yuan J,Zhang X, et al.. A Novel Exosome-Targeted CD4+ T Cell Vaccine Counteracting CD4+25+ Regulatory T Cell-Mediated Immune Suppression and Stimulating Efficient Central Memory CD8+ CTL Responses. . J Immunol.,2007;179(5):2731-40.
6、Hao S*, Jinying Yuan and Jim Xiang. Den Hurk S, Xiang JChibbar R, Xiang J. Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory. J Leukoc Biol. . J Leukoc Biol.,2007;82:829-838
7、Hao S*, Liu Y, Yuan J,Zhang X, et al.. A Novel Exosome-Targeted CD4+ T Cell Vaccine Counteracting CD4+25+ Regulatory T Cell-Mediated Immune Suppression and Stimulating Efficient Central Memory CD8+ CTL Responses. . J Immunol.,2007;179(5):2731-40.
8、Hao S and Jim Xiang.*. cancer immunotherapy by exosome-based vaccines. . Cancer Biother Radiopharm.,2007;22(5):692-703.
9、Hao S*, Ou Bei, Jinying Yuan and Xiang J. Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity. . Immunology,2007;120:90-102.
10、Huang Hui **, Hao S *, Fang Li, Zhenmin Ye, Junbao Yang and Jim Xiang.. CD4+ Th1 cells promote CD8+ Tc1 cell survival, memory response, tumor localization and therapy by targeted delivery of interleukin 2 via acquired pMHC I complexes. . Immunology,2007;120:148-159.
11、Xia D**, Hao S *, and Jim Xiang. . CD8+ cytotoxic T-APC stimulate central memory CD8+ T cell responses via acquired peptide-MHC class I complexes and CD80 costimulation, and IL-2 secretion.. The Journal of Immunology,2006; 177: 2976-84
12、Xia D**, Hao S *, and Jim Xiang. . CD8+ cytotoxic T-APC stimulate central memory CD8+ T cell responses via acquired peptide-MHC class I complexes and CD80 costimulation, and IL-2 secretion.. The Journal of Immunology,2006;177: 2976-84
13、Hao S*,Ou Bai, Jinying Yuan, Jim Xiang. Dendritic cell-derived exosomes stimulate stronger CD8+ CTL responses and antitumor immunity than tumor cell-derived exosomes. . Cellular and Molecular Immunology,,2006;3:205-11.
14、Shi M*, Hao S, Chan T, Xiang J . CD4+ T cells stimulate memory CD8+ T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion. . J Leukoc Biol.,2006;80:1354-63.
15、Hao S*, Zhenmin Ye, Jinying Yuan and Jim Xiang. Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cell-released exosomes. . Exp Oncol.,2006;28(2):126-31.
16、Hao S*, Ou Bai, Jinying Yuan, Jim Xiang . Intradermal vaccination of dendritic cell-derived exosomes is superior to a subcutaneous one in the induction of antitumor immunity. . Cancer Biother Radiopharm,,2006;21(2):146-54.
17、Shi M**, Hao S *, Su L, Yuan J, Bi X, Guo X and Xiang J. Vaccine of engineered tumor cells secreting stromal cell-derived factor-1 induce T-cell-dependent antitumor responses.. Cancer Biother Radiopharm,,2005; 20(4):401-9
18、Shi M**, Hao S *, Qureshi M, Guo X and Xiang J. Significant tumor regression by Microencapsulated cells secreting recombinant fusion protein. Cancer Biother Radiopharm. . Cancer Biother Radiopharm,,2005;20(3):260-6
19、Shi M**, Hao S *, Qureshi M, Guo X and Xiang J. Significant tumor regression by Microencapsulated cells secreting recombinant fusion protein. Cancer Biother Radiopharm. . Cancer Biother Radiopharm,,2005;20(3):260-6
20、Hao S*, Bi X, Liping Su, Dong W and Xiang J. Molecular and immunophenotypical characterization of progressive and regressive leukemia cell lines. . Cancer Biother Radiopharm,,2005;20:284-293.
21、Hao S*, Bi X, Liping Su, Dong W and Xiang J. Molecular and immunophenotypical characterization of progressive and regressive leukemia cell lines. . Cancer Biother Radiopharm,,2005;20:284-293.
22、Hao S*, Su L, Guo X, Moyana T and Xiang J. . A Novel Approach to Tumor Suppression with Microencapsulated Engineered J558/ TNF-a Cells. . Exp Oncol,,2005;27(1):56-60
23、郝思国*,孙关林,邬维礼等. 人骨髓基质细胞共培养体系能促进脐血CD133+细胞的扩增。 . 中华器官移植杂志,2005;26(1):28-32
24、Hao S*, Huang H and Xiang J. Enhanced Antitumor Immunity Derived From a Novel Vaccine of Fusion Hybrid Between Dendritic and Engineered Myeloma Cells. . Exp Oncol,,2004;26:300-306
25、郝思国*,孙关林,邬维礼等. TGF-β1对体外扩增中脐血造血祖细胞生物学特性的影响. . 中国实验血液学杂志,2004;12(1):1-9
26、郝思国*,孙关林,邬维礼等. 维甲酸对体外扩增中脐血造血干细胞分化的调节作用. . 中华血液学杂志,2004;25(11):689-691


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