上海交通大学医学院研究生导师简介陈源文

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上海交通大学免费考研网/2013-01-10

基本信息

导师姓名:	陈源文	专业代码:	100201
性别:	男	专业名称:	内科学
培养单位:	新华医院	三级学科/ 专业领域:	消化系病
导师类型:	硕士生导师	专业学位导师:
联系方式:	shsmus@263.net 上海市控江路1665号消化内科 200092

研究方向 (点击浏览详细信息)

脂肪性肝病等慢性肝损伤与细胞外基质重构

社会任职

中华医学会肝病学分会脂肪肝与酒精性肝病学组秘书

上海市中西医结合学会器官纤维化分会青年委员

科研项目

项目编号	项目名称	课题来源	起止时间	科研经费	承担职责
XYQ2011010	脯氨酰寡肽酶调控肝损伤修复功能研究	上海市卫生局，新优秀青年医学人才计划	2012-01~~2014-12	60万元	课题负责人
81170410	脯氨酰寡肽酶对慢性肝损伤时局部微环境的调节和双重与协同调控损伤修复的作用研究	国家自然科学基金委，面上项目	2012-01~~2015-12	60万元	课题负责人
211233146-10	甘丙肽及其受体调控肝星状细胞生物学行为研究	新疆维吾尔自治区自然科学基金	2012-01~~2014-12	10万元	课题负责人
10PJ1407600	肝内源性AcSDKP的调控及其肝内生理功能研究	上海市科委，浦江人才计划	2010-07~~2013-09	20万元	课题负责人
30571263	左心室组织中不同分布位置的TNF-α在容量超负荷所致左心室离心性重构过程中作用研究	国家自然科学基金委，面上项目	2010-01~~2012-12	31万元	课题负责人
30500236	IL-10或uPA基因修饰骨髓源性肝干细胞移植防治肝纤维化的比较研究	国家自然科学基金委，面上项目	2006-01~~2008-12	25万元	课题负责人

学术论文 (#为通讯作者,*为共同第一作者)

1、Wei CC, Chen Y, Powell LC, Zheng J, Shi K, Bradley WE, Powell P, Ahmad S, Ferrario CM, Dell'italia LJ. Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss. Plos One,2012;7(6):40110-40115
2、Chen YW, Pat B, Gladden JD, Zheng J, Powell P, Wei CC, Cui X, Husain A, Dell'italia LJ. Dynamic molecular and histopathological changes in the extracellular matrix and inflammation in the transition to heart failure in isolated volume overload. Am J Physiol Heart Circ Physiol,2011;300(6):H2251-60
3、Ulasova E, Gladden JD, Chen Y, Zheng J, Pat B, Bradley W, Powell P, Zmijewski JW, Zelickson BR, Ballinger SW, Darley-Usmar V, Dell'italia LJ. Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload. J Mol Cell Cardiol,2011;50(1):147-156
4、Chen YW, Liu BW, Zhang YJ, Chen YW, Dong GF, Ding XD, Xu LM, Fan JG, Li DG. Preservation of basal AcSDKP attenuates carbon tetrachloride-induced fibrosis in the rat liver. J Hepatol,2010;53(3):528-536
5、Chen Y, Pat B, Zheng J, Cain L, Powell P, Shi K, Sabri A, Husain A, Dell'italia LJ. Tumor necrosis factor-alpha produced in cardiomyocytes mediates a predominant myocardial inflammatory response to stretch in early volume overload. J Mol Cell Cardiol,2010;49(1):70-78
6、Pat B, Chen Y, Killingsworth C, Gladden JD, Shi K, Zheng J, Powell PC, Walcott G, Ahmed MI, Gupta H, Desai R, Wei CC, Hase N, Kobayashi T, Sabri A, Granzier H, Denney T, Tillson M, Dillon AR, Husain A, Dell'italia LJ. Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation. Circulation,2010;122(15):1488-1495
7、Pat B, Killingsworth C, Chen Y, Gladden JD, Walcott G, Powell PC, Denney T, Gupta H, Desai R, Tillson M, Dillon AR, Dell'italia LJ. Mast cell stabilization decreases cardiomyocyte and LV function in dogs with isolated mitral regurgitation. J Card Fail,2010;16(9):769-776
8、Zheng J, Chen Y, Pat B, Dell'italia LA, Tillson M, Dillon AR, Powell PC, Shi K, Shah N, Denney T, Husain A, Dell'Italia LJ. Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog. Circulation,2009;119(15):2086-2095
9、Lan L, Chen Y, Sun C, Sun Q, Hu J, Li D. Transplantation of bone marrow-derived hepatocyte stem cells transduced with adenovirus-mediated IL-10 gene reverses liver fibrosis in rats. Transpl Int,2008;21(6):581-592
10、Sun C, Li DG, Chen YW, Chen YW, Wang BC, Sun QL, Lu HM. Transplantation of urokinase-type plasminogen activator gene-modified bone marrow-derived liver stem cells reduces liver fibrosis in rats. J Gene Med,2008;10(8):855-866
11、Chen YW, Li DG, Wu JX, Chen YW, Lu HM. Tetrandrine inhibits activation of rat hepatic stellate cells stimulated by transforming growth factor-beta in vitro via up-regulation of Smad 7. J Ethnopharmacol,2005;100(3):299-305