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上海交通大学医学院研究生导师简介 许迅

上海交通大学 免费考研网/2013-01-10

基本信息
导师姓名: 许迅 专业代码: 100212
性别: 专业名称: 眼科学
培养单位: 第一人民医院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: drxuxun@tom.com 上海市虹口区海宁路100号 200080
研究方向 (点击浏览详细信息)
生物肽和蛋白的筛选及其在眼科的应用研究
糖尿病视网膜病变的发病机理及防治研究
社会任职
上海医学会眼科学分会 主任委员
全国眼底病学组 副组长
中华医学会眼科学分会 委员
《激光眼科学》副主编
《中华眼底病杂志》副主编
《中华眼视光学与视觉科学杂志》副主编
《Ophthalmologica》编委
《中华眼科杂志》编委
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
81273424新型多肽抑制眼部炎症的作用机制及通透性和安全性研究国家自然基金委,面上项目2013-01~~2016-1267万元课题负责人
81170862新型多肽抑制视网膜新生血管机制及眼内缓释系统研究国家自然基金委,面上项目2012-01~~2015-1262万元课题负责人
2011ZX09302-007-02新药临床研究技术平台建设—治疗眼底病创新药物临床评价研究平台的构筑“十二五“国家科技重大专项2011-01~~2013-121420.29万元课题负责人
30930097UCP-2调节的线粒体增殖及功能在2型糖尿病视网膜病变发病和防治中的作用及其临床意义国家自然基金委, 重点项目2010-01~~2013-12170万元课题负责人
30872827抑制眼部新生血管新肽的作用机制研究国家自然基金委,面上项目2009-01~~2011-1236万元课题负责人
30772370STAT3信号系统在糖尿病视网膜病变中的作用机制及意义国家自然基金委,面上项目2008-01~~2010-1229万元课题负责人
2007BAI18B07糖尿病视网膜病变视功能保护关键技术的研究“十一五”国家科技支撑计划2007-01~~2009-12250万元课题负责人
20060248077聚腺苷二磷酸核糖聚合酶对糖尿病视网膜病变发病的作用机制及干预研究国家教育部,博士点基金2007-01~~2009-126万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Xu Yan, Zhou Huan-Ming, Li Jun, Ke Bi-Lin, Xu Xun#. Efficacy of treatment for pterygium by autologous conjunctival transplantation and mitomycin C. Chinese Medical Journal,2012;125(20):3730-3734
2、Li J, Zhao SZ, Wang PP, Yu SP, Zheng Z, Xu X#. Calcium mediates high glucose-induced HIF-1α and VEGF expression in cultured rat retinal Müller cells through CaMKII-CREB pathway. Acta Pharmacologica Sinica,2012;33(8):1030-1036
3、Dawei Luo, Ying Fan, Xun Xu#. The effects of aminoguanidine on retinopathy in STZ-induced diabetic rats. Bioorganic & Medicinal Chemistry Letters,2012;22(13):4386-4390
4、Sun Q, Sun T, Xu Y, Yang XL, Xu X#, Wang BS, Tetsuya Nishimura, Heinrich Heimann. Primary Vitrectomy Versus Scleral Buckling for the Treatment of Rhegmatogenous Retinal Detachment: A Meta-Analysis of Randomized Controlled Clinical Trials. Current Eye Research,2012;37(6):492-499
5、Wang HY, Cui XF, Gu Q, Chen Y, Zhou J, Kuang Y, Wang ZG, Xu X#. Retinol dehydrogenase 13 protects the mouse retina from acute light damage. Mol Vis,2012;18:1021-1030
6、WANG Hai-yan, GU Qing, XU Xun#. Methanesulfonic acid sodium salt protects retina from acute lightdamage in mice. Chin Med J,2012;125(13):2310-2315
7、Ying Zheng, Qing Gu, Xun Xu#. Inhibition of ocularneovascularization by a novelpeptide derived from humanplacenta growth factor-1. Acta Ophthalmologica,2012;90:512-523
8、Jun Li,Peipei Wang,Songping Yu,Zhi Zheng,Xun Xu#. Calcium entry mediates hyperglycemia-induced apoptosisthrough Ca2+/calmodulin-dependent kinase ll in retinal capillaryendothelial cells. Molecular Vision,2012;18:2371-2379
9、Dongqing Zhu, Jibo Zhou, Xun Xu#. Influence of Lactic Acid on Differential Expression ofVascular Endothelial Growth Factor and PigmentEpithelium-derived Factor in Explants of Rat Retina. Current Eye Research,2012;37(11), 1025–1029
10、Zhang. ZH, Jin HY, Suo Y, Patel SV, Montes-Mico R, Manche EE, Xu X#. Femtosecond laser versus mechanical microkeratome laser in situ keratomileusis for myopia: Metaanalysis of randomized controlled trials. Journal of Cataract and Refractive Surgery,2011;37:2151-9
11、Yang X, Jin H, Liu K, Gu Q, Xu X#. A novel peptide derived from human pancreatitis-associated protein inhibits inflammation in vivo and in vitro and blocks NF-kappa B signaling pathway. PLoS One,2011;6(12):29155
12、Jin H, Yang X, Liu K, Gu Q, Xu X#. Effects of a novel peptide derived from human thrombomodulin on endotoxin-induced uveitis in vitro and in vivo. FEBS Lett,2011;585(21):3457-64
13、Sun T, Cao H, Xu L, Zhu B, Gu Q, Xu X#. lnsulin-Like Growth Factor Binding Protein-Related Protein l Mediates VEGF-lnduced Proliferation,Migration and Tube Formation of Retinal Endothelial Cells. Curr Eye Res,2011;36(4):341-349
14、Xu L, Liu YM, Yao ZJ, Xun GL, Yu WJ, Liu K, Sun XD, Qiu YP, Wu HX, Xu X#. Generation of trans-arachidonic acid under nitrative stress is associated with upreulation of thromposdin-1 in diabetic rats. Chin Med J,2011;124(12):1885-1889
15、Chen YH, Xu X#, Sheng MJ, Zheng Z, Gu Q. Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression. Mol Vis,2011;17:332-40
16、Wang H, Zheng Z, Gong Y, Zhu B, Xu X#. Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, U83836E Inhibits Retinal Neurodegeneration in Early-Stage Streptozotocin-Induced Diabetic Rats. Ophthalmic Res,2010;46(1):19-24
17、Xu Y, Zhao H, Zheng Y, Gu Q, Ma J, Xu X#. A novel antiangiogenic peptide derived from hepatocyte growth factor inhibits neovascularization in vitro and in vivo. Mol Vis,2010;16(7):1982-1995
18、Zheng Z, Chen H, Wang H, Ke B, Zheng B, Li Q, Li P, Su L, Gu Q, Xu X#. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. Diabetes,2010;59(9):2315-25
19、Zheng Z, Chen HB, Zhao H, Liu K, Luo DW, Chen YD, Chen YH, Yang XL, Gu Q, Xu X#. Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro. Invest Ophthalmol Vis Sci,2010;51(1):64-71


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