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上海交通大学医学院研究生导师简介 郑志

上海交通大学 免费考研网/2013-01-10

基本信息
导师姓名: 郑志 专业代码: 100212
性别: 专业名称: 眼科学
培养单位: 第一人民医院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: zzheng8@yahoo.com.cn 上海市虹口区海宁路100号,邮编20080
研究方向 (点击浏览详细信息)
玻璃体视网膜疾病
社会任职
上海市玻璃体手术学组委员
眼科行政副主任
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
81271032SIRT1 调节的组蛋白H3 表观遗传修饰在糖尿病视网膜病变代谢记忆中的作用国家自然基金面上项目2013-01~~2016-1285万元课题负责人
2011046泛素-蛋白酶体通路在糖尿病视网膜病变发病中的作用机制及意义上海市领军人才计划2012-01~~2015-1225万元课题负责人
201158LKB1/AMPK通路在糖尿病视网膜病变发病中的作用上海市卫生局优秀学科带头人计划2011-01~~2013-12100万元课题负责人
2010B097PGC-1α在糖尿病视网膜病变新生血管发病中的作用及其临床意义上海市白玉兰科技人才基金项目2011-01~~2012-122.5万元课题负责人
81070739PGC-1α调控的线粒体ROS通路在2型糖尿病视网膜病变早期发病中的作用国家自然科学基金面上项目2011-01~~2013-1235万元课题负责人
2010021基于线粒体ROS通路的糖尿病视网膜病变早期发病干预研究上海市人才发展基金2011-01~~2013-1210万元课题负责人
2010CB535006AMPKα对线粒体ROS通路的调控在2型糖尿病视网膜病变早期发病中的作用973计划前期研究专项课题2010-07~~1013-0865万元课题负责人
30872828SOCS-3在糖尿病性视网膜病变发病中作用机制及意义国家自然科学基金面上项目2009-01~~2011-1230万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、 Zheng Z#, Chen H, Li J, Li T, Zheng B, Zheng Y, Jin H, He Y, Gu Q, Xu X. Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. Diabetes,2012; 61(1):217-228
2、Chen H,Zheng Z*,Huang Y,Guo K,Lu J,Zhang L,Yu H,Bao Y,Jia W. A microalbuminuria threshold to predict the risk for the development of diabetic retinopathy in type 2 diabetes mellitus patients. PLoS One,2012;7(5): e36718
3、Zhao S, Li T, Zheng B, Zheng Z#. Nitric oxide synthase 3 (NOS3) 4b/a, T-786C and G894T polymorphisms in association with diabetic retinopathy susceptibility: A meta-analysis. Ophthalmic Genet,2012;33(4):200-7
4、Jin J, Zhou KK, Park K, Hu Y, Xu X, Zheng Z#, Tyagi P, Kompella UB, Ma JX. Anti-inflammatory and Antiangiogenic Effects of Nanoparticle-Mediated Delivery of a Natural Angiogenic Inhibitor. Invest Ophthalmol Vis Sci,2011;52(9):6230-6237
5、 Zheng B, Li T, Chen H, Xu X, Zheng Z#. Correlation between Ficolin-3 and Vascular Endothelial Growth Factor-to-Pigment Epithelium-Derived Factor Ratio in the Vitreous of Eyes with Proliferative Diabetic Retinopathy. Am J Ophthalmol,2011;152(6):1039-1043
6、Chen HB, Zheng Z*, Li RX, Lu JX, Bao YQ, Ying XF, Zeng R, Jia WP. Urinary pigment epithelium-derived factor as a marker of diabetic nephropathy. Am J Nephrol,2010;32(1):47-56
7、Wu H, Xia X, Jiang C, Wu J, Zhang S, Zheng Z, Liu W, Zhang Y, Ren H, Wei C, Xu X. High glucose attenuates insulin-induced VEGF expression in bovine retinal microvascular endothelial cells. Eye,2010;24(1):145-151
8、Zheng Z#, Chen HB, Wang H, Ke BL, Zheng BQ, Li Q, Li PY, Su L, Gu Q, Xu X. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial ROS pathway mediated by PGC-1α. Diabetes,2010; 59(9): 2315-2325.
9、Zheng Z, Chen HB, Ke GJ, Fan Y, Zou HD, Sun XD, Gu Q, Xu X,Ho PC. The protective effect of perindopril on diabetic retinopathy is associated with decreased VEGF/PEDF ratio: involvement of a mitochondria-ROS pathway. Diabetes,2009;58(4):954-964
10、Chen YH, Xu X, Sheng MJ, Zhang XY, Gu Q, Zheng Z#. PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy. Exp Eye Res,2009;89(6):1028-1034
11、Zhao H, Jin H, Li Q, Gu Q, Zheng Z, Wu H, Ye S, Sun X, Xu X, Ho PC. KV11, a small peptide derived from human apolipoprotein(a), inhibits VEGF-induced retinal neovascularization: the safety, penetration, and efficacy. Invest Ophthalmol Vis Sci,2009;50(11):5384-5395
12、Zhu D, Xu X, Zheng Z, Gu Q. Regulation of vascular endothelial growth factor and pigment epithelium-derived factor in rat retinal explants under retinal acidification. Eye,2009;23(11):2105-2111
13、Chen HB, Jia W, Xu X, Fan Y, Zhu D, Wu H, Xie Z, Zheng Z#. Upregulation of PEDF expression by PARP inhibition contributes to the decrease in hyperglycemia-induced apoptosis in HUVECs. Biochem Biophys Res Commun,2008;369(2):718-724
14、Chen YD, Xu X, Xia X, Wu H, Liu K, Zheng Z, Zhu D. MMP9 is involved in glycation end-products induced increase of retinal vascular permeability in rats and the therapeutic effect of minocycline. Curr Eye Res,2008;33(11):977-983
15、Zheng Z, Chen HB, Xu X, Li CX. Effects of angiotensin-converting enzyme inhibitors and β-adrenergic blockers on retinal vascular endothelial growth factor expression in rat diabetic retinopathy. Exp Eye Res,2007;84(4):745-752


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