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上海交通大学医学院研究生导师简介 葛盛芳

上海交通大学 免费考研网/2013-01-10

基本信息
导师姓名: 葛盛芳 专业代码: 071010
性别: 专业名称: 生物化学与分子生物学
培养单位: 第九人民医院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: geshengfang@hotmail.com
研究方向 (点击浏览详细信息)
疾病分子生物学基础及其基因治疗
社会任职
曾兼任上海市生物化学与分子生物学学会理事。任<转化医学杂志>编委,《上海交通大学学报(医学版)》审稿人。
上海法院知识产权技术咨询专家
《CANCER LETTER》等审稿人。
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
XDA01040411肿瘤干细胞分离、鉴定及特异标记物的研究及基于肿瘤干细胞特征的靶向药物研究中科院干细胞先导专项A类2013-01~~2017-12200万元课题参与人
81172323导入PRC2基因修复肿瘤细胞IGF2遗传印迹丢失的作用及其机制研究国家自然科学基金项目2012-01~~2015-1264万元课题负责人
10979034重离子协同腺病毒载体靶向杀灭肿瘤细胞的机理研究国家自然科学基金2010-01~~2012-1236+18万元课题负责人
2010CB529902靶向基因治疗的应用基础研究973计划2010-01~~2014-12144万元课题参与人
091024851基因-MicroRNA共表达新型腺病毒对荷瘤鼠肿瘤生长的影响第三期国家大学生创新性实验计划项目2009-11~~2011-063万元课题负责人
09ZZ110基因-小干扰RNA共表达肿瘤基因治疗新策略的研究上海市教委科研创新重点项目2009-01~~2011-1215万元课题负责人
08ZR1412500基因-小干扰RNA共表达策略在肿瘤基因治疗中的应用研究上海市自然基金2008-10~~2010-0910万元课题负责人
ZD0702Trail-siPROM1共表达双靶点胃肠肿瘤干细胞基因治疗新策略研究仁济医院合作研究项目2007-10~~2010-0925万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Wang H, Song X, Zhang H, Zhang J, Shen X, Zhou Y, Fan X, Dai L, Qian G, Hoffman AR, Hu JF, Ge S [葛盛芳(通讯作者)]#. Potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts. Int J Cancer(IF 5.444),2012;15;130 (2):443-53
2、Hao Y, Ma Y, Wang X, Jin F, Ge S.. Short-term muscle atrophy caused by botulinum toxin-A local injection impairs fracture healing in the rat femur.. J Orthop Res,2012;30(4):574-80
3、Wang Z, Jia R, Ge S(葛盛芳), He T, Zhang Y, Yang Y, Wang Y, Shi W, Ji Y, Ye F, Chen P, Lu J, Sun J, Xu X, Zhou Y, Gu P, Luo M, Lu H, Fan X. Ocular Complications of Human Immunodeficiency Virus Infection in Eastern China. Am J Ophthalmol(IF 4.239),2012;153(2):363-369
4、Zhang J, Sun Q, Zhang Z, Ge S[葛盛芳], Han ZG, Chen WT. Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. Oncogene (IF 7.414),2012;0(0):01-8
5、Cun B, Song X, Jia R, Zhao X, Wang H, Ge S [葛盛芳], Fan X. Combination of oncolytic adenovirus and dacarbazine enhances antitumor ability against uveal melanoma cells via cell cycle block . Cancer Biology & Therapy,2012;13(2):77-84
6、Guo H, Hu X, Ge S[葛盛芳], Qian G, Zhang J. Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation. Int J Biochem Cell Biol(IF 4.956),2012;44(9):1465-72
7、Huang X, Jia R, Zhao X, Liu B, Wang H, Wang J, Zhou Y, Cun B, Ge S#, Fan X.. Recombinant oncolytic adenovirus H101 combined with siBCL2: cytotoxic effect on uveal melanoma cell lines. Br J Ophthalmol,2012 Jul 27;96(10):1331-8
8、Xin Song, Haibo Wang, Renbing Jia, Biyun Cun, Xiaoping Zhao, Yixiong Zhou, Xiaofang Xu, Guanxiang Qian, Shengfang Ge(通讯作者) and Xianqun Fan#. Combined treatment with an oncolytic adenovirus and vincristine antitumor activity against retinoblastoma cells. Int. J. Mol. Sci.,2012;13(0):10736-10749
9、Fan J, Zhou Y, Huang X, Zhang L, Yao Y, Song X, Chen J, Hu J, Ge S, Song H, Fan X.. The combination of polyalanine expansion mutation and a novel missense substitution in transcription factor FOXL2 leads to different ovarian phenotypes in blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) patients.. Hum Reprod.(IF 4.475),2012;27(11):3347-57
10、Huang X, Wang L, Zhang H, Wang H, Zhao X, Qian G, Hu J, Ge S(通讯作者)#, Fan X. Therapeutic efficacy by targeting correction of notch1-induced aberrants in uveal tumors. PLoS ONE (IF 4.537),2012;7(8):44301-0
11、Yao Y, Wang L, Zhang H, Wang H, Zhao X, Zhang Y, Zhang L, Fan X, Qian G, Hu J, Ge S#. A Novel Anticancer Therapy That Simultaneously Targets Aberrant p53 and Notch Activities in Tumors. PLoS ONE,2012;7(10):46627-0
12、Sun J, Zhou J, Zhao P, Lian J, Zhu H, Zhou Y, Sun Y, Wang Y, Zhao L, Wei Y, Wang L, Cun B, Ge S, Fan X. High Prevalence of Myopia and High Myopia in 5060 Chinese University Students in Shanghai. Invest Ophthalmol Vis Sci.,2012;53(12):7504-9
13、Sun J, Zhou H, Deng Y, Zhang Y, Gu P, Ge S, Fan X.. Conditioned Medium from Bone Marrow Mesenchymal Stem Cells Transiently Retards Osteoblast Differentiation by Downregulating Runx2. Cells Tissues Organs,2012;196(6):510-522
14、Hu S, Luo Q, Cun B, Hu D, Ge S, Fan X and Chen F. The Pharmacological NF-κB Inhibitor BAY11-7082 Induces Cell Apoptosis and Inhibits the Migration of Human Uveal Melanoma Cells. Int. J. Mol. Sci.,2012;13(6):15653-15667
15、Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S [葛盛芳(通讯作者)]#. Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1.. Cancer (IF 5.131),2011;117(1):86-95
16、Zhang H, Niu B, Hu JF, Ge S(葛盛芳), Wang H, Li T, Ling J, Steelman BN, Qian G, Hoffman AR.. Interruption of intrachromosomal looping by CTCF decoy proteins abrogates genomic imprinting of human insulin-like growth factor II. Journal of Cell biology (IF 10.264),2011;193(3):475-87
17、Xu H, Ni P, Chen C, Yao Y, Zhao X, Qian G, Fan X, Ge S[葛盛芳(通讯作者)]#. SP1 suppresses phorbol 12-myristate 13-acetate induced up-regulation of human regucalcin expression in liver cancer cells.. Mol Cell Biochem,2011;355(1):9-15
18、Zhang J, Huang S, Zhang H, Wang H, Guo H, Qian G, Fan X, Lu J, Hoffman AR, Hu JF, Ge S[葛盛芳(通讯作者)]. #. Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3’-UTR microRNA.. Int J Cancer (IF 4.926).,2010;126(9):2229-2239
19、Zhou Y, Song X, Jia R, Wang H, Dai L, Xu X, Gu P, Ge S, Fan X. Radiation-inducible human tumor necrosis factor-related apoptosis inducing ligand (TRAIL) gene therapy:a novel treatment for radioresistant uveal melanoma.. Pigment Cell & Melanoma Research(IF 4.75),2010;23:661-674
20、Zhang P, Ying L, Xu R, Ge S[葛盛芳(通讯作者之一)]#, Mei W, Li F, Dai B, Lu J, Qian G. Tumor-Specific, Hypoxia-Regulated WWOX Expression Adenovirus Inhibits Human Non-Small Cell Lung Cancer Growth in Vivo. . Human Gene Therapy(IF 4.829).,2010;21(1):27-39
21、Song X, Zhou Y, Jia R, Xu X, Wang H, Hu J, Ge S, Fan X. Inhibition of retinoblastoma in vitro and in vivo with conditionally replicating oncolytic adenovirus H101. . Investigative Ophthalmology and Vision Science(IF 3.466),2010; 51(5):2626-35
22、Zhang J, Guo H, Qian G, Ge S, Ji H, Hu X, Chen W.. MiR-145, a new regulator of the DNA Fragmentation Factor-45 (DFF45)-mediated apoptotic network. Mol Cancer(IF 4.16),2010;9(1):211-220
23、Xiao C, Zhou H, Ge S[葛盛芳], Tang T, Hou H, Luo M, Fan X.. Repair of orbital wall defects using biocoral scaffolds combined with bone marrow stem cells enhanced by human bone morphogenetic protein-2 in a canine model.. Int J Mol Med,2010;26(4):517-525
24、Zhang H, Wang H, Zhang J, Qian G, Niu B, Fan X, Lu J, Hoffman AR, Hu JF, Ge S[葛盛芳(通讯作者)]. #. Enhanced Therapeutic Efficacy by Simultaneously Targeting Two Genetic Defects in Tumors.. Mol Ther(IF 7.149).,2009;17 (1):57-64
25、Zhang X, Mei W, Zhang L, Yu H, Zhao X, Fan X, Qian G, Ge S[葛盛芳(通讯作者)]. #. Co-expression of P1A35-43/β2m fusion protein and co-stimulatory molecule CD80 elicits effective anti-tumor immunity in the P815 mouse mastocytoma tumor model.. Oncol Rep.,2009;22(5):1213-1220
26、Ben QW, Zhao Z, Ge SF(葛盛芳), Zhou J, Yuan F, Yuan YZ.. Circulating levels of periostin may help identify patients with more aggressive colorectal cancer.. Int J Oncol.,2009;34(3):821-8.
27、Fang L, Wang K, Liu X, Zhang L, Zhang X, Qian L, Lu J, Qian G, Ge S[葛盛芳(通讯作者)]. #. A Study on the Anti-Tumor Immunity Induced by Gene-Modified Melanoma B16 Cells. . Oncol Rep.,2008;19(6):1589-95
28、Zhao X, Wang L, Sun Y, Ye L, Lu J, Yuan Y, Qian G, Ge S[葛盛芳(通讯作者)]. #. The endoplasmic reticulum (ER)-target protein Bik induces Hep3B cells apoptosis by the depletion of the ER Ca(2+) stores.. Mol Cell Biochem.,2008;312(1-2):33-8
29、X. Liu, L. Zhang, X. Zhang, H. Yu, X. Zhao, J. Lu, G. Qian ,S. Ge[葛盛芳(通讯作者)]. #. The effect of co-expression costimulatory molecule CD80 on uptake of antigen peptide-MHC class I-GFP complex by specific T cells. . Int J Oncol.,2007;30(6):1389-1396
30、Zhao X, Sun Y, Yu H, Ye L, Zhang L, Lu J, Yuan Y, Qian G, Ge S[葛盛芳(通讯作者)]. #. Apoptosis induced by BIK was decreased with RNA interference of caspase-12. . Biochem Biophys Res Commun.,2007;359(4):896-901.
31、Yu H, Zhao X, Huang S, Lu J, Qian G, Ge S[葛盛芳(通讯作者)] .#. Blocking Notch1 Signaling by RNA Interference can Induce Growth Inhibition in Hela Cells.. Int J Gynecol Cancer.,2007;17(2):511-6.
32、Jia RB, Zhang P, Zhou YX, Song X, Liu HY, Wang LZ, Luo M, Lu J, Ge SF[葛盛芳(共同通讯作者)]#, Fan XQ. . VEGF-Targeted RNA Interference Suppresses Angiogenesis and Tumor Growth of Retinoblastoma.. Ophthalmic Res.,2007;39(2):108-115.
33、 Li K, Cai R, Dai BB, Zhang XQ, Wang HJ, Ge SF(葛盛芳), Xu WR, Lu J. . SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron. Biochem Biophys Res Commun.,2007;27;356(1):6-12
34、Xu R, Zhang P, Huang J, Ge S(葛盛芳), Lu J, Qian G.. Sp1 and Sp3 regulate basal transcription of the survivin gene.. Biochem Biophys Res Commun.,2007;356(1):286-92


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