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上海交通大学医学院研究生导师简介 李晓

上海交通大学 免费考研网/2013-01-10

基本信息
导师姓名: 李晓 专业代码: 100201
性别: 专业名称: 内科学
培养单位: 第六人民医院 三级学科/
专业领域:
血液病
导师类型: 博士生导师 专业学位导师:
联系方式: lixiao3326@yahoo.com.cn 021-64369181-8745021-64369181-8336
研究方向 (点击浏览详细信息)
骨髓增生异常综合征的发病机制及诊治
社会任职
上海血液病研究所副所长;美国血液学会委员;中华血液学杂志编委;白血病淋巴瘤杂志编委;中国实验血液学杂志编委;中国抗癌学会协作组执行委员
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
2012AA02A505急性粒细胞白血病的分子分型和个体化诊疗技术国家高技术研究发展计划(863计划)2013-01~~2015-1220万元子课题负责人
81270584/H0807PcG蛋白EZH2在MDS表观遗传学发病机制中的作用及靶向干预研究国家自然科学基金2013-01~~2016-1270万元课题负责人
2008BAI61B02骨髓增生异常综合征的规范化诊断与治疗策略研究十一五国家科技支撑计划2008-06~~2013-0620万元子课题负责人
064119635骨髓增生异常综合征和急性髓细胞白血病恶性克隆细胞生物学特性研究上海市科委2006-01~~2008-1230万元课题负责人
044119630三氧化二砷/TRAIL作为骨髓增生异常综合征治疗新药的临床前期研究上海市科委2004-01~~2006-1230万元课题负责人
00ZB14045骨髓增生异常合征凋亡细胞类型及与凋亡因子的相关性上海市科委2001-01~~2003-1220万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Feng Xu , Rui Yang , Lingyun Wu et al. . Overexpression of BMI1 confers clonal cells resistance to apoptosis and contributes to adverse prognosis in myelodysplastic syndrome. . Cancer Letters,2012;317: 33–40
2、Xu Feng AND Li Xiao. The role of Histone methyltransferase EZH2 in myelodysplastic syndromes. Expert Rev.Hematol.,2012; 5(2):177-185
3、Li Xiao#,Zhu Qi, Chen Qiusheng et al. . The use of selective immunosuppressive therapy on myelodysplastic syndromes in targeted populations results in good response rates and avoids treatment-related disease progression. Am J Hematol.,2012;87(1):26-31.
4、Yang Y, Zhang Q, Xu F,et al. . Tumor suppressor gene BLU is frequently downregulated by promoter hypermethylation in myelodysplastic syndrome. J Cancerres Clin Oncol,2012;138(5): 729-37
5、Xu Feng, Wu lingyun, He Qi et al. . Immunophenotypic analysis of erythroid dysplasia and its diagnostic application in myelodysplastic syndromes.. Internal Medicine Journal,2012;42(4): 401-411
6、Xu F, Li X#, Wu L, Zhang Q, et al. . Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring.. Ann Hematol,2011;90:643–653
7、Zhang Zheng, Xu Feng, Li Xiao#, et al. . Removal of autologous activated CD4-positive T lymphocytes also results in increased colony-forming units in patients with low and intermediate-1 risk myelodysplastic syndromes.. Eur J Haematol,2011;86(1)47-56
8、Lingyun Wu, Xiao Li#, Jiying Su, et al.. Efficacy and safety of CHG regimen (low-dose cytarabine, homoharringtonine with G-CSF priming) as induction chemotherapy for elderly patients with high-risk MDS or AML transformed from MDS . J Cancer Res Clin Oncol,2011;137:1563–1569
9、He Q, Li X#, Zhang Z,, et al.. Overexpression of IGF-IR in Malignant Clonal Cells in Bone Marrow of Myelodysplastic Syndromes. . Cancer Invest,2010;28(10):983-988
10、Xu F, Li X#, Wu L, et al. Flow cytometric scoring system (FCMSS) assisted diagnosis of myelodysplastic syndromes (MDS) and the biological significance of FCMSS-based immunophenotypes.. Br J Haematol.,2010;149 (4):587-97
11、Li Xiao#,Liao Qiong,Zhang yan et al.. Experimental and clinical characteristics in myelodysplastic syndrome patients with or without HLA-DRI5 allele. . Hematol Oncol,2010;28:98-103
12、Xiao Li#, Feng Xu, Qi He, et al.. Comparison of Immunological Abnormalities of Lymphocytes in Bone Marrow in Myelodysplastic Syndrome (MDS) and Aplastic Anemia (AA). Inter Med,2010;49:1349-1355
13、Zhang Zheng, Zhang Qianqiao, He Qi,et al. #. In vitro deprivation of CD8CD57 T cells promotes the malignant growth of bone marrow colony cells in patients with ower-risk myelodysplastic syndrome. Experimental Hematology,2010;38:677–684
14、Li X et al#. Diagnosis of unknown non- hematological tumors by bone marrow biopsy: a retrospective analysis of 10112 samples. J Cancer Res Oncol,2009;135:687-693
15、LINGYUN WU, XIAO LI#, JIYING SU,et al.. Effect of low-dose cytarabine, homoharringtonine and granulocyte colony-stimulating factor priming regimen on patients with advanced myelodysplastic syndrome or acute myeloid leukemia transformed from myelodysplastic syndrome. . Leukemia Lymphoma,2009;50(9): 1461–1467
16、Li Xu, Chunkang Chang, Xiao Li#,et al.. Appropriate Timing of G-CSF Use After Mobilization Chemotherapy Significantly Increases the Yield of CD341 Cells in autoPBSCT.. Journal of Clinical Apheresis,2009;24(6):232-237
17、Li Xiao#, Song Luxi, Tao Ying, et al.. Diagnosis of unknown nonhematological tumors by bone marrow biopsy: a retrospective analysis of 10,112 samples. . J Cancer Res Clin Oncol,2009;135:687–693
18、Li Xu, Chunkang Chang, Xiao Li#,et al.. Appropriate Timing of G-CSF Use After Mobilization Chemotherapy Significantly Increases the Yield of CD34+ Cells in autoPBSCT.. Journal of Clinical Apheresis,2009;24(6):232-237
19、L. WU, X Li#, C Chang, et al.. Deviation of type I and type II T cells and its negative effect on hematopoiesis in myelodysplastic syndrome.. Int J Lab Hematol,2008;30(5):390-399
20、Li X#, Wu L, Ying S, et al.. Clonality investigation of morphologically dysplastic hematopoietic cells in myelodysplastic syndrome marrows. . Int J Hematol,2008;87(2):176-83.
21、Li Xiao et al#. Differentiation and hematopoietic- support of clonal cells in myelo- dysplastic syndromes. Leukemia and Lymphoma,2007;48(7):1353-1371
22、Li Xiao et al#. Wilm’s tumor gene (WT1) is predominantly expressed in clonal hematopoietic cells in myelodysplastic syndromes. Leukemia and Lymphoma,2007;48(3):601-604


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