上海交通大学医学院研究生导师简介张晓玲

删除或更新信息，请邮件至freekaoyan#163.com(#换成@)

上海交通大学免费考研网/2013-01-10

基本信息

导师姓名:	张晓玲	专业代码:	071009
性别:	女	专业名称:	细胞生物学
培养单位:	健康科学研究所	三级学科/ 专业领域:	未设
导师类型:	博士生导师	专业学位导师:
联系方式:	xlzhang@sibs.ac.cn xlzhang@sibs.ac.cn

研究方向 (点击浏览详细信息)

干细胞分化及骨软骨的修复和再生

骨关节炎的病理机制及干预控制

新型载体材料及基因输送体系的研发和应用

社会任职

国际华人骨研学会（ICHTS）理事会理事

美国骨科研究学会（ORS）会员

国际骨矿学会（IBMS）会员

国际华人硬组织学会（ICHTS）会员

中国骨科学会会员

中国微米纳米技术学会会员

中国细胞生物学学会会员

上海细胞生物学学会会员

Clinical and Experimental Immunology 审稿人

Acta pharmacologina Sinica 审稿人

Osteoporosis international 审稿人

Inflammation research 审稿人

生理学报审稿人

上海交通大学学报医学版审稿人

中国组织工程研究与临床康复杂志编委

国家自然基金评审专家

教育部学位中心评审专家

科研项目

项目编号	项目名称	课题来源	起止时间	科研经费	承担职责
11QH1401600	Wnt/β-catenin信号在软骨内骨化中的调控	上海市科委启明星跟踪计划项目	2011-04~~2013-03	15万元	课题负责人
10SG22	骨髓间充质干细胞成骨分化的表观遗传学调控	上海市教委（教育发展基金会）曙光计划项目	2011-01~~2012-12	15万元	课题负责人
KSCX2-EW-Q-1-07	C/EBP-alpha在骨髓间充质干细胞成骨成脂分化中的表观遗传学调控	中国科学院知识创新工程重要方向项目	2011-01~~2013-12	80万元	主要责任人
YG2010MS48	基于可降解聚精胺纳米基因输送系统的骨再生治疗研究	上海交通大学“医工交叉研究基金”项目	2010-06~~2012-05	8万元	课题负责人
2010B065	破骨细胞骨吸收关键蛋白Ac45功能研究	上海市科委白玉兰项目	2010-06~~2011-05	2万元	课题负责人
1013J3	间充质干细胞免疫调节、分化调控的机制及临床应用研究	中科院方向性项目	2010-01~~2010-12	30万元	课题负责人
2010CB945600	组织干细胞的干性维持、分化控制和免疫调节研究	科技部重大研究计划（973）	2010-01~~2014-08	2600万元	子课题负责人
30910369	聚合物纳米粒介导 SiRNA 关节基因转移的应用基础研究	国家自然基金国际合作	2009-07~~2009-12	4万元	课题负责人
30871435	C/EBP-alpha在骨髓间充质干细胞成骨分化中的表观遗传学调控	国家自然基金	2009-01~~2011-12	33万元	课题负责人
30811120440	构筑叶酸靶向非病毒纳米基因输送体系治疗关节炎的研究	国家自然科学基金国际(地区)合作交流项目NSFC-CIHR（中加）	2009-01~~2011-12	45万元	子课题负责人
08411950400	骨关节炎的临床分期标准和阶梯化治疗方案研究	上海市科学技术委员会重点科技支撑计划	2008-10~~2011-09	25万元	课题负责人
08410701800	构筑新型靶向阳离子聚合物纳米基因输送体系治疗关节炎的研究	上海市国际合作项目	2008-09~~2010-09	25万元	课题负责人
30700402	去铁胺对BMP2 诱导的骨髓间充质干细胞向成骨细胞分化的调控	国家自然科学基金青年基金	2008-01~~2010-12	15万元	课题负责人
07QA14062	去铁胺对骨髓间充质干细胞向成骨细胞分化的调控	上海市启明星人才基金	2007-09~~2009-09	13万元	课题负责人

学术论文 (#为通讯作者,*为共同第一作者)

1、C. Zuo, Y. Huang, R. Bajis, M. Sahih, Y.-P. Li, K. Dai, X. Zhang. #. Osteoblastogenesis regulation signals in bone remodeling. . Osteoporos Int.,2012; [Epub ahead of print]
2、Hong-guang Xu, Xiao-hai Zhang, Hong Wang, Ping Liu, Ling-ting Wang, Chi-jian Zuo, Wen-xue Tong, Xiao-ling Zhang.#. Intermittent Cyclic Mechanical Tension (ICMT) Induced Calcification and Down-regulation of ankh Gene Expression of End-plate Chondrocytes.. Spine.,2012;DOI: 10.1097/BRS.0b013e318244d989
3、Jreyssaty C, Shi Q, Wang H, Qiu X, Winnik FM, Zhang X#, Dai K, Benderdour M, Fernandes JC.. Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles In Vitro.. ISRN Pharm.,2012;369270. Epub 2012 Mar 7.
4、Cao L, Liu G, Gan Y, Fan Q, Yang F, Zhang X#, Tang T, Dai K. . The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats.. Biomaterials.,2012;Epub ahead of print.
5、Li J, Huang J, Dai L, Yu D, Chen Q, Zhang X#, Dai K. . MiR-146a, an interleukin-1beta responsive microRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4.. Arthritis Res Ther.,2012;14(2):R75.Epub ahead of print.
6、Xiang S, Su J, Tong H, Yang F, Tong W, Yuan W, Wu F, Wang C, Jin T, Dai K, Zhang X. #. Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy.. Biomaterials.,2012;Epub ahead of print.
7、Shi Y, Fu Y, Tong W, Geng Y, Lui PP, Tang T, Zhang X#, Dai K.. Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway.. J Cell Biochem.,2012;Epub ahead of print.
8、Shi Q, Zhang XL, Dai KR, Benderdour M, Fernandes JC.. siRNA therapy for cancer and non-lethal diseases such as arthritis and osteoporosis.. Expert Opin Biol Ther.,2011;11(1):5-16.Epub 2010 Nov 9.
9、Shi Y, Li H, Zhang X, Fu Y, Huang Y, Lui PP, Tang T, Dai K.. Continuous cyclic mechanical tension inhibited Runx2 expression in mesenchymal stem cells through RhoA-ERK1/2 pathway. . J Cell Physiol.,2011;226(8):2159-69.doi: 10.1002/jcp.22551.
10、Shi Q, Wang H, Tran C, Qiu X, Winnik FM, Zhang X, Dai K, Benderdour M, Fernandes JC.. Hydrodynamic delivery of chitosan-folate-DNA nanoparticles in rats with adjuvant-induced arthritis.. J Biomed Biotechnol.,2011;2011:148763. Epub 2010 Dec 28.
11、Lin Z, Solomon KL, Zhang X*, Pavlos NJ, Abel T, Willers C, Dai K, Xu J, Zheng Q, Zheng M.. In vitro evaluation of natural marine sponge collagen as a scaffold for bone tissue engineering.. Int J Biol Sci.,2011;7(7):968-77.
12、Huang Y, Zhang X, Du K, Yang F, Shi Y, Huang J, Tang T, Chen D, Dai K.. Inhibition of β-catenin signaling in chondrocytes induces delayed fracture healing in mice. . J Orthop Res.,2011;doi: 10.1002/jor.21505.
13、Xiang S, Tong H, Shi Q, Fernandes JC, Jin T, Dai K, Zhang X. #. Uptake mechanisms of non-viral gene delivery.. J Control Release.,2011; [Epub ahead of print]
14、Yang C, Yuan G, Zhang J, Tang Z, Zhang X, Dai K.. Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation. . Biomed Mater.,2010;5(4):045005. Epub 2010 Jun 23.
15、Yang F, Xie Y, Li H, Tang T, Zhang X, Gan Y, Zheng X, Dai K. . Human bone marrow-derived stromal cells cultured with a plasma sprayed CaO-ZrO2-SiO2 coating.. J Biomed Mater Res B Appl Biomater.,2010;95(1):192-201.
16、Xiaoling Zhang, Tingting Tang, Qin Shi, Julio C. Fernandes, Kerong Dai. . The immunologic properties of undifferentiated and osteogenic differentiated mouse mesenchymal stem cells and its potential application in bone regeneration.. Immunobiology.,2009;214(3):179-86
17、Tong H, Qin S, Fernandes JC, Li L, Dai K, Zhang X#. Progress and prospects of chitosan and its derivatives as non-viral gene vectors in gene therapy. . Curr Gene Ther,2009;9(6):495-502
18、Tu J, Wang H, Li H, Dai K, Wang J, Zhang X#. The in vivo bone formation by mesenchymal stem cells in zein scaffolds.. Biomaterials,2009;30(26):4369-76
19、Qiming Fan, Tingting Tang, Xiaoling Zhang, Kerong Dai. . The role of CCAAT/enhancer binding protein (C/EBP) alpha in osteogenesis of C3H10T1/2 cells induced by BMP-2.. J Cell Mol Med .,2009;13(8B):2489-505.
20、Yan Huang, Xiaogang Jin, Xiaoling Zhang, Hongli Sun, Jinwen Tu, Tingting Tang, Jiang Chang, Kerong Dai.. In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration. Biomaterials,2009;30(28):5041-8.
21、Zhang P, Han D, Tang T, Zhang X, Dai K.. The destruction evaluation in different foot joints: new ideas in collagen-induced arthritis rat model. . Rheumatol Int.,2009;29(6):607-13
22、Zhang X, Tang T, Shi Q, Fernandes JC, Dai K. The immunologic properties of undifferentiated and osteogenic differentiated mouse mesenchymal stem cells and its potential application in bone regeneration.. Immunobiology,2009;214(3):179-86
23、Sun H, Dai K, Tang T, Zhang X.*. Regulation of osteoblast differentiation by slit2 in osteoblastic cells.. Cells Tissues Organs.,2009;190(2):69-80.
24、Hou H, Zhang X*, Tang T, Dai K, Ge R.. Enhancement of bone formation by genetically-engineered bone marrow stromal cells expressing BMP-2, VEGF and angiopoietin-1. . Biotechnol Lett.,2009;31(8):1183-9.
25、Zhu J, Zhang X*, Wang C, Peng X, Zhang X. . Periprosthetic strain magnitude-dependent upregulation of type I collagen synthesis in human osteoblasts through an ERK1/2 pathway.. Int Orthop.,2009;33(5):1455-60.
26、Zhang X, Zhang C, Tang T, Qu Z, Lou J, Dai K. . Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and . J Orthop Res.,2008;26(3):314-21
27、Zhang C, Tang T, Ren W, Zhang X, Dai K. Influence of mouse genetic background on wear particle-induced in vivo inflammatory osteolysis. . Inflamm Res.,2008;57(5):211-5
28、Zhang P, Han D, Tang T, Zhang X, Dai K. . Inhibition of the Development of Collagen-Induced Arthritis in Wistar Rats through Vagus Nerve Suspension: A 3-month Observation. . Inflamm Res.,2008;57(7):322-8
29、Dai KR, Zhang XL, Shi Q, Fernandes JC.. Gene therapy of arthritis and orthopaedic disorders: current experimental approaches in China and in Canada.. Expert Opin Biol Ther.,2008;8(9):1337-46.
30、Qu ZH, Wang HJ, Tang TT, Zhang XL, Wang JY, Dai KR.. Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation.. Acta Biomater,2008;4(5):1360-8
31、Han D, Sun X, Zhang X, Tang T, Dai K.. Ectopic osteogenesis by ex vivo gene therapy using beta tricalcium phosphate as a carrier.. Connect Tissue Res.,2008;49(5):343-50
32、Qu ZH, Zhang XL, Tang TT, Dai KR. . Promotion of osteogenesis through beta-catenin signaling by desferrioxamine.. Biochem Biophys Res Commun.,2008;370(2):332-7.
33、Sun X, Gan Y, Tang T, Zhang X, Dai K. . In vitro proliferation and differentiation of human mesenchymal stem cells cultured in autologous plasma derived from bone marrow. . Tissue Eng Part A.,2008;14(3):391-400.
34、Fernandes JC, Wang H, Jreyssaty C, Benderdour M, Lavigne P, Qiu X, Winnik FM, Zhang X*, Dai K, Shi Q.. Bone-protective effects of nonviral gene therapy with folate-chitosan DNA nanoparticle containing interleukin-1 receptor antagonist gene in rats with adjuvant-induced arthritis.. Mol Ther.,2008;2008 Jul;16(7):1243-51
35、Zhang C, Tang TT, Ren WP, Zhang XL, Dai KR.. Inhibiting wear particles-induced osteolysis with doxycycline.. Acta Pharmacol Sin.,2007;28(10):1603-10
36、Li H, Dai K, Tang T, Zhang X, Yan M, Lou J.. Bone regeneration by implantation of adipose-derived stromal cells expressing BMP-2.. Biochem Biophys Res Commun.,2007;356(4):836-42
37、Zhang X, Yu C, Xushi, Zhang C, Tang T, Dai K.. Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo. . Biochem Biophys Res Commun.,2006;341(1):202-8.
38、Dai KR, Xu XL, Tang TT, Zhu ZA, Yu CF, Lou JR, Zhang XL.. Repairing of goat tibial bone defects with BMP-2 gene-modified tissue-engineered bone. . Calcif Tissue Int.,2005;77(1):55-61.
39、Yue, B, Lu, B*, Dai, KR, Zhang, XL, Yu, CF, Lou, JR, Tang, TT.. BMP2 gene therapy on the repair of bone defects of aged rats.. Calcif Tissue Int.,2005;77(6): 395-403.
40、Zhang Xiaoling, Mao Zebing, Yu Changlong.. Suppression of early experimental osteoarthritis by gene transfer of interleukin 1 receptor antagonist and interleukin 10. . Journal of Orthopaedic Research.,2004;22(4):742-750.