导师介绍

导师姓名
吴强
导师性别男
职务职称研究员.
所在院系系统生物医学研究院
所属学科生物学
研究方向分子遗传学细胞发育学
联系电话34204300
电子邮箱qiangwu@1

个人简介

男，博士，上海交通大学特聘教授。吴强教授长期从事复杂基因家族的表达调控和在体功能研究。吴强团队以研究原钙粘蛋白（protocadherin）家族在脑发育和脑功能中的细胞分子机制以及UGT基因家族在药物代谢中的表达调控和结构功能为主要研究方向。我们以小鼠为模式动物对这些基因的研究将为阐明人类重要常见复杂神经精神疾病（自闭症autismspectrumdisorders、精神分裂症schizophrenia、双极性障碍bipolardisorders等）的发生发展机理以及最终对其有效治疗做出贡献。欢迎有志从事科学研究的青年加入我们团队。吴强教授先后获得的科技奖励有：ExcellenceResearchRecognitionAward;TheSecondAnnualRibozymePharmaceuticals/RNAPrizeforYoungScientists;MarchofDimesBasicO’ConnerScholar;AmericanCancerSocietyResearchScholar。研究论文先后发表于Science,MolecularandCellularBiology,Cell,PNAS,MolecularCell,GenomeResearch和NatureGenetics等期刊上，总影响因子超过160，总引用超过730。现任ActaBiochimicaetBiophysicaSinica《生物化学与生物物理学报》Editor，并为多个国际知名期刊审稿。
代表性论著

HuangH.andWu,Q*.(2010).CloningandcomparativeanalysesofthezebrafishUgtrepertoirerevealitsevolutionarydiversity.PLoSONE5:E9144.Ying,G.,Wu,S.,Hou,R.,Huang,W.,Capecchi,M.,Wu,Q*.(2009).ProtocadherinCelsr3isrequiredforinterneuronmigrationinthemouseforebrain.MolecularandCellularBiology29:3045-3061.Wu,S.,Ying,G.,Wu,Q.,andCapecchi,M.R.(2008).Aprotocolforconstructinggenetargetingvectors:generatingknockoutmiceforthecadherinfamilyandbeyond.NatureProtocol3:1056-1076.Zou,C.,Huang,W.,Ying,G.,andWu,Q*.(2007).Sequenceanalysisandexpressionmappingoftheratclusteredprotocadheringenerepertoires.Neuroscience144:579-603.Wu,S.,Ying,G.,Wu,Q.,andCapecchi,M.R.(2007).Towardssimplerandfastergenome-widemutagenesisinmice.NatureGenetics39:922-930.Li,C.andWu,Q*.(2007).Evolutionofvertebratemultiplevariablefirstexonsandstructuraldiversityofdrugmetabolizingenzymes.BMCEvolutionaryBiology7:69.Wu,Q*#.(2005).Comparativegenomicsanddiversifyingselectionoftheclusteredvertebrateprotocadheringenes.Genetics169:2179-2188.Zhang,T.,Haws,P.,andWu,Q*.(2004)Multiplevariablefirstexons:amechanismforcell-andtissue-specificgeneregulation.GenomeResearch14:70-89.Tasic,B.,Nabholz,C.E.,Baldwin,K.K.,Kim,Y.,Rueckert,E.H.,Ribich,S.A.,Cramer,P.,Wu,Q.,Axel,R.,andManiatisT.(2002).Promoterchoicedeterminessplicesiteselectioninprotocadherinandpre-mRNAsplicing.Mol.Cell10:21-33.Wu,Q#.,Zhang,T.,Cheng,J.-F.,Kim,Y.,Grimwood,J.,Schmutz,J.,Dickson,M.,Noonan,J.P.,Zhang,M.Q.,Myers,R.M.,andManiatis,T.(2001).ComparativeDNAsequenceanalysisofmouseandhumanprotocadheringeneclusters.GenomeResearch11:389-404.Wu,Q#.andManiatis,T.(2000).Largeexonsencodingmultipleectodomainsareacharacteristicfeatureofprotocadheringenes.ProcNatlAcadSciUSA97:3124-3129.PohlU.,SmithJ.S.,TachibanaI.,UekiK.,LeeH.K.,RamaswamyS.,WuQ.,MohrenweiserH.W.,JenkinsR.B.,LouisD.N.(2000).EHD2,EHD3,andEHD4encodenovelmembersofahighlyconservedfamilyofEHdomain-containingproteins.Genomics63:255-262.Wu,Q#.andManiatis,T.(1999)Astrikingorganizationofalargefamilyofhumanneuralcadherin-likecelladhesiongenes.Cell97:779-790.Wu,Q#.andKrainer,A.R.(1999)AT-ACpre-mRNAsplicingmechanismsandconservationofminorintronsinvoltage-gatedionchannelgenes.MolecularandCellularBiology19:3225-3236.Wu,Q#.andKrainer,A.R.(1998)Purine-richenhancersfunctionintheAT-ACsplicingpathwayanddosoindependentlyofintactU1snRNP.RNA4:1664-1673.Wu,Q#.andKrainer,A.R.(1997)SplicingofadivergentsubclassofAT-ACintronsrequiresthemajorspliceosomalsnRNAs.RNA3:586-601.Wu,Q#.andKrainer,A.R.(1996)U1-mediatedexondefinitioninteractionsbetweenAT-ACandGT-AGintrons.Science274:1005-1008.