导师介绍

导师姓名
俞雁
导师性别女
职务职称教授.
所在院系农业与生物学院
所属学科畜牧学
研究方向
联系电话34205833
电子邮箱yanyu@sjtu.edu.cn

个人简介

现任上海交通大学农业与生物学院教授、博士生导师、副院长分管国际合作与实验室管理。华东师范大学生物系理学学士；美国纽约MountSinai医学院生物医学博士;美国康奈尔大学医学院博士后；曾在美国马里兰州OriGeneTechnologies公司担任研究员；2004年就职上海交通大学农业与生物学院。主要从事组织损伤修复和再生的基因调控研究、以及相关基因工程药物研发。先后主持和参与国家科技攻关项目、国家自然基金、“863”项目、国家新药创制计划、上海市科委国际合作项目等多项。发表学术论文30余篇，申请专利多项。
代表性论著

HuliLu,ShunyingZhu,LanQian,DiXiang,WuZhang,AifangNie,JinGao,MingyuanWu,JinmingGao,BaoLu,YanYu,WeiHanandAnjaMoldenhauer.ActivatedexpressionofthechemokineMigfollowingchemotherapycontributestochemotherapy-inducedbonemarrowsuppressionandlethaltoxicity.Blood,2012119:4868-4877HonglinHe,TingxuYang,ShixiangJia,RUliangZhang,PingTu,JinGao,YunshengYuan,WeiHanandYanYu.Expressionandpurificationofbioactivehigh-purityhumanS100A6inEscherichiacoli.ProteinExpressionandPurification.201283:98-103ChuanyingXu,ZhonghuiZhang,MinyuanWu,ShunyingZhu,JinGao,JingZhang,YunshengYuan,YanYuandWeiHan.Recombinanthumanmidkinestimulatesproliferationanddecreasesdedifferentiationofauricularchondrocytesinvitro.ExpBiolMed.2011236:1254-1262JingjingLi,JinGao,SunitaSah,UttamSatyal,RanZhang,WeiHanandYanYu.Expressionandpurificationofbioactivehigh-purityrecombinantmouseCXCL14inEscherichiacoli.ApplBiochemBiotechnol.2011164:1366-1375JingjingLi,JinGao,DejunYan,YunshengYuan,SunitaSah,UttamSatyal,ManLiu,WeiHanandYanYu.NeutralizationofchemokineCXCL14(BRAK)expressionreducesCCl4inducedliverinjuryandsteatosisinmice.EuropeanJournalofPharmacology.2011671:120-127DiXiang,GuoYiping,JingZhang,ShunyingZhu,HuiliLu,MingyuanWu,YanYuandWeiHan.Interleukin1receptorantagonistattenuatescyclophosphamide-inducedmucositisinamurinemodel.CancerChemotherapyandPharmacology.201167:1445-1453JianjunHu,DejunYan,JinGao,ChuanyingXu,YunshengYuan,RunzhiZhu,DiXiang,ShunyanWeng,WeiHan,GuoqingZangandYanYu.rhIL-1Ra.AttenuatedHepatotoxicityPrimarilybyReducingHepatocellularApoptosisinAcetaminophen-InducedAcuteLiverFailureMice.LaboratoryInvestigation201090:1737-1749RunZhiZhu,DiXiang,ChaoXie,JingJingLi,JianJunHu,HongLinHe,YunShengYuan,JinGao,WeiHan,YanYu.Protectiveeffectofrecombinanthumaninterleukin1receptorantagonistoncarbontetrachloride-inducedacuteliverinjuryinmice.WorldJGastroenterol201014;16:2771-2779ChaoXie,JinGao,RunzhiZhu,YunshengYuan,HonglinHe,QiushiHuang,WeiHanandYanYu.Protein-proteinInteractionmapisakeygatewayintoliverregeneration.WorldJGastroenterology,2010,16:3491-3498ZhonghuiZhang,HuixianLi,YipingQi,LijuanDu,ShunyingZhu,MingyuanWu,HuiliLu,YanYuandWeiHan.Recombinanthumanmidkinestimulatesproliferationofarticularchondrocytes.CellProlif.2010,43,184–194GuoyongHu,JiaqianShen,LiCheng,DiXiang,ZhonghuiZhang,MeiHe,HuiliLu,ShunyingZhu,MingyuanWu,XiaWang,YanYuandWeiHan.PurificationofabioactiverecombinanthumanRegIVexpressedinEscherichiacoli.ProteinExpressionandPurification201069:186–190ZhengyuZheng,ShunyanWeng,YanYu.Signalmolecule-mediatedhepaticcellcommunicationduringliverregeneration.WorldJGastroenterol,200915:5776-578320.HonglinHe,JingjingLi,ShunyanWeng,MingfaLiandYanYu.S100A11:Diversefunctionandpathologycorrespondingtodifferenttargetproteins.CellBiochemBiophys,200955:117-126ZhonghuiZhang,LijuanDu,DiXiang,ShunyingZhu,MingyuanWu,HuiliLu,YanYuandWeiHan.Expressionandpurificationofbioactivehigh-purityhumanmidkineinEscherichiacoli.JZhejiangUnivSciB.200910:79-86YunshengYuan,XiaoyingWu,QiuqiangOu,JinGao,BudCTennant,WeiHan,YanYu.Differentialexpressionofthegenesinvolvedinaminoacidsandnitrogenmetabolismsduringliverregenerationofmice.HepatolRes.200939:301-12JinGao,WenxiLi,SiqianFeng,YunshengYuan,DafangWan,WeiHan,YanYu.Aprotein-proteininteractionnetworkoftranscriptionfactorsactingduringlivercellproliferation.Genomics.200891:347-55WeiHan,YanYu,andXinyuanLiu.Localsignalsinstemcell-basedbonemarrowregeneration.CellResearch,200616:189-195