摘要/Abstract

报道了一种以2-炔芳基腈和亚磺酸钠为原料，过硫酸钾为氧化剂，通过自由基串联环化反应一步构筑环戊烯并[gh]菲啶的新方法.该反应具有反应条件温和、原子经济性高、底物适应性较强等优势.利用此方法简便地合成了多种潜在的具有生物活性的4-磺化环戊烯并菲啶.
关键词: 2-炔芳基腈, 亚磺酸钠, 4-磺化环戊[gh]菲啶, 自由基串联环化反应
A convenient K₂S₂O₈-initiated radical cascade cyclization for the construction of 4-sulfonated cyclopenta[gh]-phenanthridines from 2-alkynylnitriles and sodium sulfinates has been explored under metal-free conditions. This protocol features mild conditions, good functional group tolerance and broad substrate scope. A variety of potentially bioactive 4-sulfonated cyclopenta[gh]phenanthridines were facilely synthesized via direct annulation.
Key words: 2-alkynylnitriles, sodium sulfinate, 4-sulfonated cyclopenta[gh]phenanthridine, radical cyclization cascade


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