摘要/Abstract

以低毒、廉价的铜盐作为催化剂，实现了邻烯基芳基异硫氰酸酯与叠氮化钠的串联双环化反应，简单有效地合成了一系列5H-苯并四氮唑并噻嗪衍生物.在该催化体系下，反应底物显示出良好的官能团兼容性和反应性，并以中高产率制备了5H-苯并四氮唑并噻嗪类化合物.该策略的提出为含氮、含硫小分子化合物的合成提供了一条方便的路径.
关键词: 铜催化, 串联双环化, 5H-苯并四氮唑并噻嗪, 邻烯基芳基异硫氰酸酯
A simple and efficient method for the preparation of 5H-benzo[d]tetrazolo[5,1-b] [1,3]thiazines has been developed. The transformation involved the copper(I)-catalyzed cascade bicyclization of o-alkenylphenyl isothiocyanates with sodium azide to afford corresponding products in moderate to good yields. This present strategy provides an effective way to construct small molecular N-, and S-heterocycles.
Key words: copper-catalysis, cascade bicyclization, 5H-benzo[d]tetrazolo[5,1-b] [1,3]thiazine, o-alkenylphenyl isothiocyanate


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