摘要/Abstract
报道了一种简便有效的Ru（II）催化偶氮苯与乙醛酸乙酯的高选择性[4＋1]环化反应，该反应历程涉及C—H键的活化.这种策略能够以中等至良好的产率去高效构建多样性的吲唑骨架结构.同时研究了该反应的动力学同位素效应，实验结果表明C—H键活化可能不属于整个反应历程的决速步骤.
关键词: 钌(II), C—H键活化, 环化反应, 吲唑
The Ru(II)-catalyzed regioselective[4+1] cycloaddition of azobenzenes with ethyl glyoxalate through C-H bond activation has been developed. This method provides a facile approach to various 3-carboxylate indazoles in moderate to good yields. Meantime, the kinetic isotope effect was further investigated and the results indicated that the C-H bond-breaking was possibly not involved in the rate-limiting step of this transformation.
Key words: Ru (II), C—H bond activation, cycloaddition, Indazoles
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