摘要/Abstract

N-O键断裂反应是向化合物中引入含氮、氧官能团的有效策略之一.铜催化剂来源丰富，价格便宜，铜催化剂在有机合成中占有不可替代的地位.铜催化的N-O断裂，由于具有反应条件温和、官能团兼容性好、原子经济性高等优点，在有机合成中被广泛应用于构建C-N和C-O键.N-O键的断裂策略在复杂天然产物及药物分子的合成中都有成功的应用.综述了近些年来铜金属催化N-O断裂的新策略及N-O断裂策略在天然产物和药物分子合成中的应用.
关键词: 铜催化, 杂环化合物, N-O断裂, 串联反应, 重排反应
N-O bond cleavage is one of the most efficient and powerful strategies to introduce N-or O-functional groups into molecules in organic synthesis. Copper catalyst, as the abundant in earth and inexpensive advantages has been widely used to construct C-N and C-O bond. Furthermore, N-O bond cleavage has been successfully applied in the total synthesis of natural products and pharmaceuticals. The new development of copper-catalyzed N-O bond cleavage and its application in the total synthesis of natural products and pharmaceuticals in recent years have been summarized.
Key words: copper-catalysis, heterocyclic compounds, N-O cleavage, cascade reaction, rearrangement reaction


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