摘要/Abstract
以廉价、易得的氯化镍与脯氨酸锂为催化剂，在聚乙二醇200（PEG 200）溶剂中建立一种操作简单、经济环保的2-卤代苯甲酸和脒类盐酸盐合成喹唑啉酮衍生物的方法.该方法具有操作简便、无毒和无刺激的特点，均能以较高的产率得到一系列喹唑啉酮类衍生物，最高产率达94%.
关键词: 聚乙二醇(PEG 200), 喹唑啉酮, 氯化镍, 2-卤代苯甲酸, 脒盐
A simple and economic method for synthesizing quinazolinones from substituted 2-halobenzoic acids and amidines was developed by nickel-catalysis in wet polyethylene glycol 200 (PEG 200) as an eco-friendly medium. The present methodology is operationally simple, non-toxic and non-irritative, and varieties of quinazolinone derivatives were obtained in high yields of up to 94%.
Key words: polyethylene glycol 200 (PEG 200), quinazolinone, nickel chloride, 2-halobenzoic acid, amidine
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