摘要/Abstract

Hydramicromelins A~C是具有独特化学结构和生物活性的香豆素类化合物.以本实验室发展的[2，3]-Meisenheimer重排为关键反应，以L-苯甘氨醇为起始原料，经过Wittig反应，[2，3]-Meisenheimer重排，环氧化，双羟化等7~8步反应，高收率、高对映选择性地制备出Hydramicromelins A，B和C的母核或其对映体.
关键词: Hydramicromelins A,B和C, [2,3]-Meisenheimer重排, 手性三级醇, 环氧化
Hydramicromelins A~C are coumarin compounds with unique chemical structure and biological activity. With[2,3]-Meisenheimer rearrangemen as a key reaction which has been developed in our laboratory, the core structures of Hydramicromelin A, B and C were synthesized from L-phenylglycine. The route included Wittig reaction,[2,3]-Meisenheimer rearrangement, epoxidation and dihydroxylation reaction, and it was high-yield and high-enantioselectivity.
Key words: hydramicromelins A, B and C, [2,3]-Meisenheimer rearrangement, chiral tertiary alcohol, epoxidation


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