摘要/Abstract
发展了一种Lewis酸性离子液体[Bmim]ZnBr3促进的烯胺酯与联烯酮的新型串联反应，在二者缩合生成烟酸酯衍生物的过程中，这种离子液体既作为溶剂又起着催化剂的作用，并且可以回收再利用.该串联反应具有反应时间短、处理过程简单、环境友好、产率高等优点，可为含有烟酸酯结构单元的天然产物及复杂药物分子的合成提供简便的途径.
关键词: 离子液体, 烯胺酯, 联烯酮, 烟酸酯
A novel approach for the synthesis of nicotinate derivatives has been developed by using Lewis acidic ionic liquid[Bmim]ZnBr3, which acts as dual solvent-catalyst in promoting the tandem reaction of enaminoester and allenic ketones. In the reaction process, no catalysts or other organic solvents are used, and[Bmim]ZnBr3 can be readily reused for three times without noticeable decrease in the catalytic activity after simple treatment. Furthermore, our method offers several advantages such as short reaction times, simple work-up procedure, environment-friendly solvent and good yields. The current methodology could also be conveniently applied to the synthesis of natural products and complex therapeutic agents occurring niacin frameworks.
Key words: ionic liquid, enaminoester, allenic ketone, nicotinate
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