姓 名:
　曹春阳 性 别:
　男
职 称:
　研究员 学 历:
　研究生
电 话:
　 传 真:
　
电子邮件:
　ccao@mail.sioc.ac.cn 个人主页:
　
通讯地址:
　上海市零陵路345号　200032


简历：
2006年9月至今：中科院上海有机所研究员，上海市“浦江计划”获得者
2005年12月至2006年08月：美国Salk生物研究院结构生物学中心，助理研究员
2001年09月至2005年08月：美国约翰霍普金斯大学医学院博士后与研究助理
1998年09月至2001年07月：中科院上海有机化学研究所理学博士


研究方向：
以健康与疾病导向、以NMR为主要技术手段的化学生物学与结构生物学研究。
A）与癌症或者HIV病毒感染等相关蛋白质与核酸特异性作用机制与功能研究
B）以与癌症或者HIV病毒感染等相关核酸或蛋白质为靶标，进行药物分子设计与筛选
C）基于核磁共振波谱学的蛋白质高效表达新技术新方法研究


专家类别：
研究员

职务：
课题组长

社会任职：


获奖及荣誉：
2008年 入选上海市“浦江人才”
2011年 获“王天眷基金波谱奖”


代表论著：
1) Hou, XF#, Song YJ#, Cao C*, Tang GL*, et al, Enzymology of Anthraquinone-g-Pyrone Ring Formation in Complex Aromatic Polyketides Biosynthesis, Angew Chimie Int Ed, 2018, accepted (# Co-first Author)
2) Liu HH, Lan WX, Cao C*, Gan JH*, et al, High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads, Nucleic Acid Res, 2018, accepted
3) Wang YT, Lan WX, Cao C*, et al, Solution structure of extracellular loop of human β4 subunit of BK channel and its biological implication on ChTX sensitivity, Sci Rep, 2018, 8: 4571
4) Liu YP#, Lan WX#, Cao C*, et al, A putative G-quadruplex structure in the proximal promoter of VEGFR-2 has implications for drug design to inhibit tumor angiogenesis, J. Biol. Chem. 2018 293: 8947.
5) Fang J#, Cheng JD#, Wang, JL#, Yang HR*, Cao C*, Xu YH*, et al, Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition.，Nat Commun, 2016, 711197.
6) Lan WX, Hu ZP, Cao C*, et al, Structural investigation into physiological DNA phosphorothioate modification. Sci Rep, 2016, 6, 25737.
7) Shen J, Yang ZZ, Cao C*, et al, NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway. Sci Rep, 2016, 6, 38710~38710
8) Lu XX, Zhang TL, Cao C*, et al, Crystalstructure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA, J Biol Chem, 2015, 290(7), 4010-21.
9) Liu SS, Guo H, Liu W*, Cao C*, et al, Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis, Sci Rep, 2015, 5, 12744.
10) Lan WX, Wang ZH, Cao C* Huang ZX*, et al, Structural Basis for Cytochrome c Y67H Mutant to Function as a Peroxidase, PLos One, 2014, 9(9),
11) Zhang Y, Lan WX, Xu, YH*, Cao C*, et al, The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B, Protein & Cell, 2014, 5(11), 837~850
12) Lan WX, Wang ZH, Huang ZX*, Cao C*, et al, Structural Basis for Cytochrome c Y67H Mutant to Function as a Peroxidase, PLos One, 2014, 9(9),
13) Liu SS, Zhang W, Dong YH*, Cao C*, et al, NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans，FEBS Letters, 2013, 587(16), 2635~2642
14) Zhu S, Peigneur G, Cao C*, Tytgat J*, et al, Evolutionary Diversification of Mesobuthus α-Scorpion Toxins Affecting Sodium Channels，Mol Cell Proteomics，2012, 11(1)：M111.012054~M111.012054.
15) Hu W, Wang CK, Cao C*, et al, Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification，Cell Research，2012, 22(7)：1203~1206.
16) Yang ZZ, Vild C, Cao C*, Xu Z*, et al, Structural Basis of Molecular Recognition between ESCRT-III-like Protein Vps60 and AAA-ATPase Regulator Vta1 in the Multivesicular Body Pathway，J Biol Chem, 2012, 287(52)：43899~43908.
17) Wang CK , Shen J , Yang ZZ, Cao C*, Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger，Cell Research，2011, 1(9)：1379~1382.
18) Tong XT , Lan WX, Cao C*, et al, Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence，Nucleic Acids Research，2011, 39(15)：6753~6763.
19) Yang Z, Zhang L, Cao C*, Wang XN*, et al, Highly Efficient Production of Soluble Proteins from Insoluble Inclusion Bodies by a Two-Step-Denaturing and Refolding Method，PLos One, 2011, 6(7) e22981.
20) Lan WX, Wang ZH, Huang ZX, Cao C*, et al, Conformational Toggling of Yeast Iso-1-Cytochrome c in the Oxidized and Reduced States, PLoS One. 2011; 6(11): e27219.