姓 名:
　潘李锋 性 别:
　男
职 称:
　研究员 学 历:
　博士研究生
电 话:
　 传 真:
　
电子邮件:
　panlf@sioc.ac.cn 个人主页:
　http://panlf.sioc.ac.cn
通讯地址:
　上海市零陵路345号　200032


简历：
2001年9月~ 2005年7月，复旦大学化学系（基地班），获理学学士学位。
2005年9月~ 2010年6月，香港科技大学生物化学系，获哲学博士学位。
2010年8月~ 2011年2月，香港科技大学生命科学部，助理研究员。
2011年3月~ 2012年8月，香港科技大学生命科学部，研究助理教授。
2013年1月~ 2013年4月，美国哈佛大学医学院，访问****


研究方向：
1. 以人类疾病为导向，综合利用结构生物学、生物化学、化学生物学等手段的交叉学科研究，具体包括：研究与癌症、炎症相关的细胞自噬（Autophagy）以及泛素相关领域的重要蛋白质及其复合物的结构与功能关系；研究肌萎缩侧索硬化症（ALS），老年痴呆症等神经退化性疾病，从分子层面来揭示相关的致病及调控机理。
2. 活性小分子的化学生物学研究，具体包括：天然活性小分子与靶点蛋白相互作用的机制研究；基于SAR-by-NMR方法，针对与癌症、炎症等疾病相关的重要生物靶点的小分子先导物的筛选和优化，及后期基于此先导物的机理和功能研究。


专家类别：
研究员

职务：
课题组长

社会任职：


获奖及荣誉：
2017：中国化学会青年化学奖。
2013：上海市科技启明星计划。
2011：第四届亚太核磁共振会议青年科学家旅行资助奖（口头报告）。
2010：香港科学会年度生命科学领域青年科学家奖，决赛选手；
香港科技大学生命科学部研究生科研奖；
香港大学生物化学研究生学术研讨会平台报告奖。
2009：香港科技大学生物化学系研究生科研成就奖；第三届亚太核磁共振会议青年科学家旅行资助奖。
2005：上海市优秀本科毕业生；复旦大学人民一等奖学金。
2004：复旦大学联合利华一等奖学金；复旦大学优秀学生干部。
2003：复旦大学翔鹭一等奖学金；复旦大学优秀团员。
2002：复旦大学人民一等奖学金；复旦大学三好学生。

代表论著：
1. Li F, Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L.* " Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation " Autophagy. 2018 (online)
2. Liu J, Wang Y, Gong Y, Fu T, Hu S, Zhou Z, Pan L.* "Structural Insights into SHARPIN-mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly" Cell Reports. 2017, 21(1):27-36.
3. Wei R, Xu L, Liu J, Li Y, Zhang P, Shan B, Lu X, Qian L, Wu Z, Dong K, Zhu H, Pan L, Yuan J*, Pan H*. “SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination” Genes. Dev. 2017, 31, 1162-1176.
4. Xu D, Liu J, Fu T, Shan B, Qian L, Pan L*, Yuan J.* “USP25 Regulates Wnt Signaling by Controlling the Stability of Tankyrases” Genes. Dev. 2017, 31, 1024-1035.
5. Zhang Z, Gong YK, Zhou Q, Hu Y, Ma HM, Chen YS, Igarashi Y, Pan L*, Tang GL.* “Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade” PNAS. 2017, 114, 1554-1559.
6. Li F, Xie X, Wang Y, Liu J, Cheng X, Guo Y, Gong Y, Hu S, Pan L.* "Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins" Nature Communications. 2016, 7:12708.
7. Cheng X, Wang Y, Gong Y, Li F, Guo Y, Hu S, Liu J, Pan L.* "Structural Basis of FYCO1 and MAP1LC3A Interaction Reveals a Novel Binding Mode for Atg8 Family Proteins" Autophagy. 2016, 12, 1330-1339.
8. Zheng Q, Guo Y, Yang L, Zhao Z, Wu Z, Zhang H, Liu J, Cheng X, Wu J, Yang H, Jiang H, Pan L,* and Liu W.* "Enzyme-Dependent [4+2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4" Cell Chemical Biology. 2016, 23, 352-360.
9. Xu D, Shan B, Lee B, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J.* "Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system" eLife. 2015, 4: e10510.
10.Xie X, Li F, Wang Y, Wang Y, Lin Z, Cheng X, Liu J, Chen C, Pan L.* "Molecular Basis of Ubiquitin Recognition by Autophagy Receptor CALCOCO2" Autophagy. 2015, 10, 1775-1789.
11.Xia H, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff1 J, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J*, Vakifahmetoglu-Norberg H "Degradation of HK2 by Chaperone-Mediated Autophagy promotes Metabolic Catastrophe and Cell Death" J Cell Biol. 2015, 210, 705-716.
12.Gong Y, Pan L.* "Recent advances in bioorthogonal reactions for site-specific protein labeling and engineering" Tetrahedron Letters. 2015, 56, 2123-2132 (invited Digest)
13.Yan B, Han P, Pan L, Lu W, Xiong J, Zhang M, Zhang W, Li L, Wen Z.* "IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model" J Immunol. 2014, 192, 5998-6008.
14.Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmüller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, Gloeckner CJ.* "Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain" Mol. Cell. Bio. 2014, 34, 2147-2161.
15.Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. * "Chaperone-mediated autophagy degrades mutant p53" Genes. Dev. 2013, 27, 1718-1730.
16.Yu C, Luo J, Wu J, Pan L, Feng W, Zhang M.* "Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizes" J. Biol. Chem. 2012, 287, 35021-35035.
17.Wu L#, Pan L#, Zhang C, Zhang M.* "Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia" J. Biol. Chem. 2012, 287, 33460-33471. (#:co-first authors)
18.Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M, Yue Z.*, Zhao Y.* "Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG" Nature Communications, 2012, 3:662.
19.Pan L, Zhang M.* "Structures of Usher Syndrome 1 Proteins and Their Complexes" Physiology, 2012, 27, 25-42. (invited review, cover story)
20.Pan L#, Chen J#, Yu J#, Yu H, Zhang M.* "The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Suggests a Supramodular Organization of the MAGUK Family Scaffold Protein Core" J. Biol. Chem. 2011, 286, 40069-40074. (#: co-first authors)
21.Wei Z, Yan J, Lu Q, Pan L, Zhang M.* "Cargo Recognition Mechanism of Myosin X Revealed by the Structure of its Tail MyTH4-FERM Tandem in Complex with the DCC P3 Domain" PNAS. 2011, 108, 3572-3577.
22.Feng W, Pan L, Zhang M.* "Combination of NMR spectroscopy and X-ray crystallography offers unique advantages for elucidation of the structural basis of protein complex assembly" Sci.China.Life.Sci. 2011, 54, 101-111. (invited review)
23.Wu L#, Pan L#, Wei Z, Zhang M.* "Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo" Science. 2011, 331, 757-760. (#:co-first authors, highlighted by Faculty of 1000, F1000 Cell Biology and F1000 Genomics & Genetics)
24.Diao Y, Liu W, Wong CC, Wang X, Lee K, Cheung PY, Pan L, Xu T, Han J, Yates JR 3rd, Zhang M, Wu Z.* "Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding" PNAS. 2010, 107, 20974-20979
25.Conan K Wang, Pan L, Chen J, Zhang M.* "Extensions of PDZ domains as important structural and functional elements" PROTEIN & CELL. 2010, 8, 737-751. (invited review)
26.Shi Y, Yu J, Jia Y, Pan L, Shen C, Xia J, Zhang M.* "Redox-regulated lipid membrane binding of the PICK1 PDZ domain" Biochemistry. 2010, 49, 4432-443
27.Yan J#, Pan L#, Chen X, Wu L, Zhang M.* "The Structure of the Harmonin/Sans Complex Reveals an Unexpected Interaction Mode of the Two Usher Syndrome Proteins" PNAS. 2010,107, 4040-4045. (#: co-first authors)
28.Wen W, Yu J, Pan L, Wei Z, Weng J, Wang W, Yan S, Tran T, Hong W, Zhang M.* "Lipid-induced Conformational Switch Controls Fusion Activity of Longin Domain SNARE Ykt6" Mol. Cell. 2010, 37, 383-395.
29.Pan L#, Yan J#, Wu L, Zhang M.* "Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23" PNAS. 2009, 106, 5575-5580. (#: co-first authors)
30.Chen J#, Pan L#, Wei Z, Zhao Y, Zhang M.* "Domain Swapped Dimerization of ZO-1 PDZ2 Generates Specific and Regulatory Connexin43 Binding Sites" EMBO J, 2008, 27, 2113-2123. (#: co-first authors)
31. Pan L#, Wu H#, Shen C#, Shi Y, Jin W, Xia J, Zhang M.* "Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes" EMBO J, 2007, 26, 4576-4587. (#: co-first authors)