姓 名:
　何凯雯 性 别:
　女
职 称:
　研究员 学 历:
　博士研究生
电 话:
　 传 真:
　
电子邮件:
　kwhe@sioc.ac.cn 个人主页:
　
通讯地址:
　上海市浦东新区秋月路26号6号楼　201203


简历：
1999-2003:清华大学 生物科学与技术系 学士
2004-2009:美国马里兰大学帕克分校 神经生物学博士
2009-2010:美国马里兰大学帕克分校 博士后
2011-2015:美国约翰霍普金斯大学 博士后 / 助理研究科学家


研究方向：
　　主要研究方向是神经功能调控与神经退行性疾病早期发病机制。
　　神经功能受到很多因素调控，其中我们最感兴趣的是睡眠在其中发挥的作用。睡眠作为普遍存在于生物界的一个保守的生理现象，对维持生物机体功能包括脑功能至关重要。然而，目前我们对睡眠如何调控神经功能了解得非常有限。另外，神经系统疾病如退行性疾病患者大都患有不同程度不同类型的睡眠障碍，且睡眠障碍通常远早于脑疾病其他病症出现，说明睡眠与脑疾病有非常密切的联系。因此，我们实验室研究的主要问题包括：1）正常生理状态下，睡眠对神经功能如神经信号传导、神经可塑性、神经网络稳态等的调控作用和调控机制；2）睡眠障碍与神经退行性疾病的相互关系；3）神经退行性疾病的早期发病的神经机制研究。我们将综合运用体内外电生理和显微成像、光遗传、药物学、细胞生物学、和行为学分析等多种手段，来研究以上问题。



专家类别：
研究员

职务：
课题组长

社会任职：


获奖及荣誉：
2013 Best Poster Award Johns Hopkins University
2008 Ann Wylie Dissertation Fellowship University of Maryland College Park
2008 Travel Award University of Maryland College Park
2007 Best Poster Award University of Maryland College Park
2004 Block Grand Fellowship University of Maryland College Park


代表论著：
1. He KW*#, Bridi M, Zong FJ, Wang GL, Kirkwood A#, Modulation of Neuronal Excitation/Inhibition Balance by the Dark/Light Cycle (in preparation)
2. Bridi M, Pasquale R, lantz C L, Gu Y, Choi S, He K, Tran T, Quinlan E, Kirkwood A#, Two distinct mechanisms for experience-dependent homeostasis in vivo, 2017 (Submitted)
3. He K, Huertas M, Hong S, Tie X, Hell J.W, Shouval H, Kirkwood A# (2015) Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron, 88(3): 528-38
4. Ikrar T, Guo N, He K, Besnard A, Levinson S, Hill A, Lee HK, Hen R, Xu X, Sahay A# (2013) Adult neurogenesis modulates excitability of the dentate gyrus. Frontiers in Neural Circuits. 7:204
5. Wang H*, Megill A*, He K, Kirkwood A, Lee HK# (2012) Consequences of inhibiting amyloid precursor protein (APP) processing enzymes on synaptic function and plasticity. Neural Plasticity. 2012:272374
6. He K, Petrus E, Gammon N, Lee HK#, (2012) Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity. Journal of Neuroscience. 32(25):8469-74
7. Huang S*, Trevi？o M*, He K*, Ardiles A, Pasquale R, Guo Y, Palacios A, Huganir R, Kirkwood A# (2012) Pull-push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron. 73(3):497-510 (Recommended by F1000Prime)
8. Qian H, Matt L, Zhang M, Nguyen M, Patriarchi T, Koval OM, Anderson ME, He K, Lee HK, Hell JW# (2012) The β2 Adrenergic Receptor Supports Prolonged Theta Tetanus - induced LTP. J Neurophysiol.
9. He K, Goel A, Ciarkowski CE, Song L, Lee HK# (2011) Brain area specific regulation of synaptic AMPA receptors by phosphorylation. Commun Integr Biol. 4(5):569-72
10. He K, Lee A, Song L, Kanold PO, Lee HK# (2011) AMPA receptor subunit GluR1 (GluA1) serine-845 site is involved in synaptic depression but not in spine shrinkage associated with chemical long-term depression. Journal of Neurophysiology. 105(4):1897-907
11. Lee HK, Takamiya K, He K, Song L, Huganir RL# (2010) Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. Journal of Neurophysiology. 103(1):479-89
12. He K, Song L, Cummings LW, Goldman J, Huganir RL, Lee HK# (2009) Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. PNAS, 106(47):20033-8(Recommended by F1000Prime)
13. Lee HK, Takamiya K, Kameyama K, He K, Yu S, Rossetti L, Wilen D, and Huganir RL # (2007) Idenfication and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Mol Cell Neuroscience, 36(1):86-94.
14. Laird FM*, Cai H*, Savonenko AV*, Farah MH*, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC# (2005) BACE1, a major determinant of selective vulnerability of the brain to amyloid- amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. Journal of Neuroscience, 25(50):11693-11709.
* Equally contributing authors. # Corresponding author