姓 名:
　刘聪 性 别:
　男
职 称:
　研究员 学 历:
　博士研究生
电 话:
　 传 真:
　
电子邮件:
　liulab@sioc.ac.cn 个人主页:
　http://www.ircbc.ac.cn/liulab/
通讯地址:
　上海市浦东新区秋月路26号6号楼　200032


简历：
1998-2002 吉林大学 学士 Jilin University B.S.
2002-2008 北京大学 博士 Peking University Ph.D
2008-2013 美国加州大学洛杉矶分校&霍华德休斯医学院 博士后 UCLA&HHMI Postdoc
2013.9-至今 中国科学院生物与化学交叉研究中心 研究员、课题组长


研究方向：
1. 与神经退行性疾病如阿尔兹海默病、帕金森病， 渐冻人病相关的蛋白质的错误折叠，异常积聚，和淀粉样化的分子机理和结构基础研究。
2. 新颖的结构生物学方法的发展和运用，如蛋白质纳米级晶体的电子衍射技术，in-cell NMR技术等。并运用其系统研究淀粉样蛋白在体外及体内聚集的结构基础。
3. 基于多种神经退行性疾病的重要靶点分子结构信息的药物先导物的设计，筛选和优化。
4. 基于淀粉样多肽的具有新功能的新材料设计，开发和应用。



专家类别：
研究员

职务：
课题组长

社会任职：


获奖及荣誉：
2015 入选国家高技术研究发展计划（863计划）青年科学家专题项目
2012 IUCr青年科学家国际旅行资助奖 国际晶体学会蛋白晶体学新方法会议
2012 ADDF ****科学家奖 第六届神经退行性疾病药物开发年会
2007 杰出墙报奖 第六届国际蛋白科学会议

代表论著：
1. Xie J.J., Si, X., Gu, J., Wang M.L., Shen J., Li H.Y., Shen, J, Li D., Fang Y.J., Liu C.,* Zhu J.D.* Allosteric inhibitors of SHP2 with therapeutic potential for cancer treatment. Journal of Medicinal Chemistry. Dec 28;60(24):10205-10219 (* corresponding author)
2. An B., Wang X., Cui M., Gui X., Mao X., Liu Y., Li K., Chu C., Pu J., Ren S., Wang Y., Zhong G, Lu TK., Liu C., Zhong C. Diverse Supramolecular nanofiber networks assembled by functional Low-Complexity domains. ACS Nano. 2017 Jul 25;11(7):6985-699
3. Liu Z.Y., Zhang S.N., Li D., and Liu C. A structural view of αB-crystallin assembly and
amyloid aggregation. (Review)Protein & Peptide Letters, 2017, 24(4):315-321.
4. Wang C.C., Zhao C.Y., Li D., Tian Z.Q., Lai Y., Diao J.J.*,Liu C.* Versatile Structures of a-Synuclein. (Review) Frontiers in Molecular Neuroscience, 2016, 9, 48. (* corresponding author)
5. Yang G., Zhang X., Kochovshi Z., Zhang Y., Dai B., Sakai F., Jiang L., Lu Y., Ballauff M., Li X.,Liu C.*, Chen G.*, Jiang M.Precise and reversible protein microtubule-like structure with helicity driven by dual supramolecular interactions. J. Am. Chem. Soc., 2016, 138, 1932-1937. (* corresponding author)
6. Dai B., Li D., Xi W.H., Luo F., Zhang X., Zou M., Cao M., Hu J., Wang W.Y., Wei G.H.*, Zhang Y.*,Liu C.* Tunable assembly of amyloid-forming prptides into nanosheets as a retrovirus carrier. Proc. Natl. Acad. Sci. USA., 2015, 112, 2996-3001. (* corresponding author)
7. Li D., Jones E.M., Sawaya M.R., Furukawa H., Luo F., Ivanova M., Sievers S.A., Wang W.Y., Yaghi O.M.,Liu C., Eisenberg D.S. Structure-based design of functional amyloid materials. J. Am. Chem. Soc., 2014, 136, 18044-188051.
8. Gu L.,Liu C., Stroud J.C., Ngo S., Jiang L., Guo Z. Antiparalle triple-strand architecture for prefibrillar Abeta42 oligomers. J. Biol. Chem., 2014, 289, 27300-27313.
9. Hochberg G.K.A., Ecroyd H.,Liu C., Cox D., Cascio D., Sawaya M.R.,et al.The structured core domain of aB-crystallin can prevent amyloid fibrillation and associated toxicity. Proc. Natl. Acad. Sci. U.S.A.,2014, 111, 1562-1570.
10.Li D., Furukawa H., Deng H,Liu C., Yaghi O.M., Eisenberg D.S.Designed amyloid fibers as materials for selective carbon dioxide capture. Proc. Natl. Acad. Sci. U.S.A.,2014, 111, 191-96.
11.Jiang L.？,Liu C.？, Leibly D., Landau M., Zhao M.L., Hughes M.,et al.Structure-baseddiscovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. Elife, 2013, 00857. (？ Authors contributed equally)
12.Gu L.,Liu C., Guo Z.Structure insights into Aβ42 oligomers using site-directed spin labeling. J. Biol. Chem., 2013, 288, 18673-18683.
13.Liu C.？, Zhao M.L.？, Jiang L.？, Cheng P.N., Park J.Y., Sawaya M.,et al.Out-of-registerβ-sheets suggesta pathway to toxicamyloid aggregations.Proc. Nat. Acad. Sci. U.S.A., 2012, 109, 0913-0918. (？ Authors contributed equally)
14.Cheng P.N.？,Liu C.？, Zhao M.L., Eisenberg D. and Nowick J.Amyloid β-sheet mimics that antagonize protein aggregation and reduceamyloidtoxicity.Nat. Chem., 2012, 4, 927-933. (？ Authors contributed equally)
15. Li D., Fu T.M., Nan J.,Liu C., Li L.F., and Su X.D.Structural basis forthe autoinhibition of the C-terminal kinase domain of human RSK1. Acta Crystallogr. D,2012, 68, 680-685.
16. Stroud J.C.？,Liu C.？, Teng P.K. and Eisenberg D.Toxic fibrillar oligomers of amyloid-β have cross-β structure.Proc. Nat. Acad. Sci. U.S.A., 2012, 109, 7717-7722. (？ Authors contributed equally)
17.Laganowsky A.,Liu C., Sawaya M.R., Whitelegge J.P., Park J., Zhao M.,et al.Atomic view of a toxic amyloid small oligomer. Science, 2012, 335, 1228-1231.
18.Liu C.？, Sawaya M.R.？, Cheng P.N., Zheng J.,Nowick J.S. and Eisenberg D.Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics.J. Am. Chem. Soc., 2011, 133, 6736-6744. (？ Authors contributed equally)
19.Zheng J.,Liu C., Sawaya M.R., Vadla B., Khan S., Woods R.J.,et al.Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. J. Am. Chem. Soc., 2011, 133, 3144-3157.
20.Liu C., Sawaya M.R. and Eisenberg D.β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat. Struct. Mol. Biol., 2011, 18, 49-55.