基于功能磁共振成像的肠易激综合征患者脑网络动态特性研究
南姣芬¹, 孟攀婷¹, 宗楠楠¹, 张金灿^2,*
1郑州轻工业大学计算机与通信工程学院，郑州 450001；²郑州大学管理工程学院，郑州 450001
摘要
脑-肠互动紊乱是肠易激综合征(irritable bowel syndrome, IBS)发病的重要原因，但其脑功能动态特性仍不清楚。本研究针对以往基于功能磁共振成像的脑网络动态分析的缺点，提出一种基于逐时间点斜率分析的动态特性度量方法，以此来检测IBS患者脑功能动态异常变化情况。结果表明，与健康被试相比，IBS患者脑活动及功能连接均发生一定程度的改变。在经过FDR (false discovery rate)校正之后，只有右侧后扣带-左侧额中回、右侧后扣带-左侧苍白球这两条功能连接上表现出显著的动态特性异常，该结果与IBS患者的静态特性存在较大差异。以上结果为阐明IBS异常的机制提供了互补信息，可为IBS中枢靶点的揭示提供新的方向。


关键词： 功能磁共振成像; 大脑; 功能连接; 动态特性; 肠易激综合征
分类号：TP391; R445.2

Dynamic characteristics of brain networks in patients with irritable bowel syndrome based on functional magnetic resonance imaging
NAN Jiao-Fen¹, MENG Pan-Ting¹, ZONG Nan-Nan¹, ZHANG Jin-Can^2,*
1School of Computer and Communication Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China；²School of Management Engineering, Zhengzhou University, Zhengzhou 450001, China
Abstract
The disorder of brain-gut interaction is an important cause of irritable bowel syndrome (IBS), but the dynamic characteristics of the brain remain unclear. Since there are many shortcomings for evaluating brain dynamic nature in the previous studies, we proposed a new method based on slope calculation by point-by-point analysis of the data from functional magnetic resonance imaging, and detected the abnormalities of brain dynamic changes in IBS patients. The results showed that compared with healthy subjects, there were dynamic changes in the brain for the IBS patients. After correction by false discovery rate (FDR), significant abnormalities were only found in two functional connections of the right posterior cingulate gyrus linked to left middle frontal gyrus, and the right posterior cingulate gyrus linked to left pallidus. The above results of the brain dynamic analysis were totally different from those of the brain static analysis of IBS patients. Our findings provide novel complementary information for illustrating the central nervous mechanism of IBS and may offer a new direction to explore central target for patients with IBS.


Key words: functional magnetic resonance imaging; brain; functional connectivity; dynamic characteristics; irritable bowel syndrome

收稿日期：2021-01-15　　录用日期：2021-05-06
通讯作者：张金灿　　E-mail: zhangjincanzhengda@163.com
DOI: 10.13294/j.aps.2021.0033
引用本文：
南姣芬, 孟攀婷, 宗楠楠, 张金灿. 基于功能磁共振成像的肠易激综合征患者脑网络动态特性研究[J]. 生理学报 2021; 73 (3): 355-368.
NAN Jiao-Fen, MENG Pan-Ting, ZONG Nan-Nan, ZHANG Jin-Can. Dynamic characteristics of brain networks in patients with irritable bowel syndrome based on functional magnetic resonance imaging. Acta Physiol Sin 2021; 73 (3): 355-368 (in Chinese with English abstract).



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