铁死亡在呼吸系统疾病中的研究进展及应用
陈海霞, 吴燕萍, 李雯, 沈华浩, 陈志华^*
浙江省呼吸疾病诊治及研究重点实验室，浙江大学医学院附属第二医院呼吸与危重症医学科，杭州 310009
摘要
铁死亡(ferroptosis)是一种新发现的细胞死亡调控方式，依赖于铁和活性氧簇，主要特征是细胞内脂质过氧化物堆积。与其他细胞死亡方式相比，铁死亡在形态、生物化学、遗传学等方面有自身的特点。铁死亡的发生机制与非酶促反应或者酶促反应触发铁催化的脂质过氧化物堆积有关。近年来的研究显示铁死亡与血液系统、心脑血管、肝肾系统等多种疾病相关，然而在呼吸系统疾病中的研究相对较少。本文就铁死亡的定义、机制、诱导剂、病理生理状态下的铁死亡以及铁死亡在呼吸系统疾病中的相关研究展开综述，以期为呼吸系统疾病的临床防治提供新思路、新靶点。
关键词： 铁死亡; 呼吸系统疾病; 铁死亡诱导剂; 脂质过氧化物
分类号：R714.253

Ferroptosis in respiratory diseases
CHEN Hai-Xia, WU Yan-Ping, LI Wen, SHEN Hua-Hao, CHEN Zhi-Hua^*
Key Laboratory of Respiratory Diseases of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
Abstract
Ferroptosis is a novel form of regulated cell death which is dependent on iron and reactive oxygen species (ROS) and associated with the accumulation of lipid peroxides. It is obviously different from other cell death types in terms of morphology, biochemistry, genetics, etc. Also, it is related to the production of iron catalyzed lipid peroxides which is triggered by non-enzymatic or enzymatic reactions. Ferroptosis has been proved to be involved in hematological diseases, cardio-cerebrovascular diseases, liver and kidney diseases. This paper will review the definition, mechanism, inducers of ferroptosis, as well as the function of ferroptosis in respiratory system. We expect to present a new concept for respiratory research and suggest potential targets for clinical prevention and treatment of respiratory diseases.


Key words: ferroptosis; respiratory diseases; ferroptosis inducers; lipid peroxides

收稿日期：2020-04-29　　录用日期：2020-08-18
通讯作者：陈志华　　E-mail: zhihuachen@zju.edu.cn
DOI: 10.13294/j.aps.2020.0064
引用本文：
陈海霞, 吴燕萍, 李雯, 沈华浩, 陈志华. 铁死亡在呼吸系统疾病中的研究进展及应用[J]. 生理学报 2020; 72 (5): 575-585.
CHEN Hai-Xia, WU Yan-Ping, LI Wen, SHEN Hua-Hao, CHEN Zhi-Hua. Ferroptosis in respiratory diseases. Acta Physiol Sin 2020; 72 (5): 575-585 (in Chinese with English abstract).



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