血管发育相关microRNAs的研究进展
陈祺¹, 许强华^1,2,3,4,*
1上海海洋大学海洋科学学院，上海 201306；²大洋渔业资源可持续开发省部共建教育部重点实验室，上海 201306；³国家远洋渔业工程技术研究中心，上海 201306；⁴远洋渔业协同创新中心，上海 201306
摘要
脊椎动物血管系统的发育是一个极其重要且复杂的过程。MicroRNAs在转录及转录后水平对基因表达起调控作用，参与了诸多重要的生理、病理过程。MicroRNAs主要在血管平滑肌细胞和血管内皮细胞的发育调控中发挥着重要作用。本文归纳了近年来有关microRNAs在血管发育中的研究进展，着重阐述了miR-126、miR-17/92家族等在血管内皮细胞中的调控作用机制，以及miR-143/145家族、miR-21等在血管平滑肌细胞中的调控作用机制。本文还对microRNAs在血管发育中作用的研究前景作了展望。


关键词： 血管发育; microRNA; 调控
分类号：Q756

Research progress on microRNAs involved in vascular development
CHEN Qi¹, XU Qiang-Hua^1,2,3,4,*
1College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China；²Key Laboratory of Sustainable Exploitation of Ocean Fisheries Resources, Ministry of Education, Shanghai 201306, China；³National Distant-water Fisheries Engineering Research Center, Shanghai 201306, China；⁴Collaborative Innovation Center for Distant-water Fisheries, Shanghai 201306, China
Abstract
The vertebrate vascular system development is a very important and complicated process. MicroRNAs regulate gene expression at transcriptional and post-transcriptional levels and play important roles in many physiological and pathological processes. MicroRNAs mainly participate in the regulation of vascular smooth muscle cell and vascular endothelial cell development. In this paper, we summarize the recent progress regarding the microRNAs involved in the vascular development. In particular, we focus on the microRNAs including miR-126, miR-17/92 family in endothelial cell’s regulation, and miR-143/145 family, miR-21 in vascular smooth muscle cell’s regulation. The future research on the role of microRNAs in vascular development is also prospected.


Key words: vascular development; microRNAs; regulation

收稿日期：2018-03-07　　录用日期：2018-09-20
通讯作者：许强华　　E-mail: qhxu@shou.edu.cn
DOI: 10.13294/j.aps.2018.0062
引用本文：
陈祺, 许强华. 血管发育相关microRNAs的研究进展[J]. 生理学报 2018; 70 (5): 548-556.
CHEN Qi, XU Qiang-Hua. Research progress on microRNAs involved in vascular development. Acta Physiol Sin 2018; 70 (5): 548-556 (in Chinese with English abstract).



PDF全文下载地址:

点我下载PDF