Klotho与肾损伤及修复的研究进展
戴厚永, 杨斌^*
南通大学附属医院肾内科，南通 226001
摘要
Klotho蛋白在肾脏高表达，可溶型Klotho广泛分布于血液、尿液和脑脊液中，在体内发挥重要内分泌样功能。Klotho在肾损伤中的作用日益受到重视，已有研究表明Klotho在急性肾损伤(acute kidney injury, AKI)中呈暂时性，而在慢性肾脏病中呈持续性肾脏局部和系统性缺陷。Klotho可望成为肾损伤的生物标志物，有利于AKI早期诊断及反映其向慢性肾损伤的进展，并有潜在的治疗价值。然而，对Klotho如何影响AKI修复的研究有限。本综述着重讨论Klotho在AKI及修复中的作用，特别是Klotho与细胞命运(坏死/凋亡/自噬)、修复/再生、Wnt/β-catenin和促红细胞生成素受体(Klotho的效应因子之一)的关系。
关键词： Klotho; 急性肾损伤; 修复; 生物标志物
分类号：R334.1;R692

Research update of Klotho in kidney injury and repair
DAI Hou-Yong, Yang Bin^*
Department of Nephrology, Affiliated Hospital of Nantong University, Nantong 226001, China
Abstract
Klotho is highly expressed in the kidney, while soluble Klotho is detectable in the blood, urine, and cerebrospinal fluid, and has multiple hormone-like functions. The role of Klotho in kidney injury has attracted more and more attentions from researchers. Emerging evidence revealed that the transient deficiency of Klotho is an early event of acute kidney injury (AKI), whereas, in chronic kidney disease, this deficiency is sustained not only in the kidney, but also in other organ systems. Therefore, Klotho could be a potential biomarker for early diagnosis of AKI, as well as for its progression to chronic kidney disease. Moreover, Klotho might have therapeutic value to renal injury. Nevertheless, there are only few studies on the involvement of Klotho in post AKI repair. This review focused on the role of Klotho in not only kidney injury, but also its repair, in particular the relationship between Klotho and cell fate (autophagy/apoptosis/necrosis), repair/regeneration, Wnt/β-catenin and erythropoietin receptor, one of the Klotho effectors.


Key words: Klotho; acute kidney injury; repair; biomarker

收稿日期：2018-06-05　　录用日期：2018-10-12
通讯作者：杨斌　　E-mail: by5@le.ac.uk; dryangbin@hotmail.com
DOI: 10.13294/j.aps.2018.0072
引用本文：
戴厚永, 杨斌. Klotho与肾损伤及修复的研究进展[J]. 生理学报 2018; 70 (6): 639-643.
DAI Hou-Yong, Yang Bin. Research update of Klotho in kidney injury and repair. Acta Physiol Sin 2018; 70 (6): 639-643 (in Chinese with English abstract).



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