在岗研究生导师情况介绍
所系名称生化与细胞所
性别男
专业名称生物化学与分子生物学
技术职务研究员
行政职务研究组长
Mail地址zhoulab@sibs.ac.cn
指导博士
生总数10指导硕士
生总数2已毕业学生通讯地址上海岳阳路320号
目前博士
生数6目前硕士
生数2目前在校生邮政编码200031
研究方向细胞衰老和真核细胞维持染色体稳定性的机制
研究工作我们实验室的长远目标是探索真核细胞维持染色体稳定性的机制和细胞衰老的机理。目前主要研究（1）染色体末端-端粒的结构、功能与复制,及其与癌症和细胞衰老的关系；（2）不依赖端粒长度的细胞衰老的机理。
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ToNewGraduateStudent
July1,2005
DearNewGraduateStudent,
CongratulationsonyourexcellentperformanceintheentranceexaminationandadmissionoftheInstituteofBiochemistryandCellBiology,andWELCOMEtovisitourlab.
Thelong-termgoalofourlabistounderstandtheprocessesthateukaryoticcellsfaithfullymaintaintheirchromosomestoavoidchromosomalinstability.Mostofourworkhasbeenfocusingonthestructure,functionandreplicationoftelomeres,andhowtelomeraseactivityisregulatedineukaryotes.Recently,welaunchedastudyoncellularaging.
Ourlabhasmainlybeensupportedbythefollowingfunds:“Hundred-TalentProjectsProgram”byChineseAcademyofSciences,JointProgramofMax-PlanckSocietyandChineseAcademyofSciences,“OutstandingYoungScientistProgram”fromNationalScienceFunction.Theequipmentinthelabmeetsmostofthedailyrequirementsofourresearch.Ourgroupisnowinmediumsize:twotechnicians,8graduatestudents.Inordertostrengthenourteamandbringusmorefreshair,Weplantoaccepttwotothreenewstudentsthisschoolyear.
Sincetherotationwasbroughtinoureducationsystem,wehaveprovidedabout20rotationopportunitiesforgraduatestudents,and10ofthemhavebeencontinuingtheirresearchinourlab.Inthecomingschoolyear,wewelcomeyoutorotateinourlab.However,weusuallyacceptnomorethanthreerotationstudentseverytime.Theremightbemoreapplicantsthanwecansupportbecauseofspacelimit.Therefore,wewillorganizeameetinginwhicheverystudentwhowishtorotateinourlabhasanopportunitytoexpresshim/herself.InthemeetingthatwillbeheldinearlySeptemberinourlab,youareinvitedtogiveusa10-minPowerPointpresentationinEnglishifyoufeelcomfortable.Thepresentationwillallowustoknowyoubetter:whatthesisworkyoudidinundergraduate;howmuchyouknowaboutyourthesiswork;howyouexpressyourself.Ms.FuXiaohong,agraduatestudentinourlab(phone#54921077),willhelpyouinthismatterifyouneedhelpormoreinformation.
Wewillbeexpectingtoseeyouinthemeetingbecausewedeeplyknowthatyourjoiningintoourgroupwillbringusbothmorechallenges,moreideas,moreactivitiesandmoresmiling,morehappinessandmorehope.
Ifyouareinterestedinattendingtheinterviewmeeting,pleaseemailusatzhoulab@sibs.ac.cnassoonaspossible,andwewilltellyouwhenandwherewewillhavethemeeting.
Finally,wewishyouenjoyyourgraduatelife,andthankyouforyourconsiderationofourlab.
获奖情况NA
指导研究
生情况目前在学研究生：博士生6名;硕士生1名。
已毕业离开实验室研究生：博士生9名;硕士生1名
个人简介1984年至1988就读于南京大学生物系,获学士学位.
1992至1997年就读于美国迈阿密大学医学院生物化学与分子生物学系,获博士学位.
1998年至2001,在美国普林斯顿大学分子生物学系接受博士后训练.
2001年9月,作为”百人计划”入选者受聘于生物化学与细胞生物学研究所,任研究员,博士生导师.
2002年1月起,任中国科学院与德国马普学会合作的青年科学家小组组长.
近期论文1．MengF.-L.,HuY.,ShenN.,TongX.-J.,WangJ.-Y.,DingJ.-P.andZhouJ.-Q.(2009).Sua5pasingle-strandedtelomericDNA-bindingproteinfacilitatestelomerereplication.TheEMBOJournal.28:1466-1478.
2．QianW.,WangJ.-Y.,JinN.-N.,FuX.-H.,LinY.-C.,LinJ.-J.andZhouJ.-Q.(2009)Ten1ppromotesthetelomericDNAbindingacivityofCdc13p:animplicationforitsfunctionintelomerelengthregulation.CellResearch.19:850-863.
3．ZhouJ.,ZhouB.,LenzmeierB.-A.andZhouJ.-Q.(2009).HistonedeacetylaseRpd3antagonizesSir2-dependentsilentchromatinpropagation.NuclearAcidResearch.37:3699-3713.
4．ChenX.F.,MengF.-L.andZhouJ.-Q.(2009).TelomererecombinationacceleratescellularaginginSaccharomycescerevisiae.Plosgenetics.5:1-14.
5．FuX.-H.,MengF.-L.,HuY.andZhouJ.-Q.(2008).Candidaalbicans,adistinctivefungalmodelforcellularagingstudy.AgingCell.7:746-757.
6．YangC.-P.,ChenY.-B.,MengF.-L.andZhouJ.-Q.(2006).SaccharomycescerevisiaeEst3pdimerizesinvitroanddimerizationcontributestoefficienttelomerereplicationinvivo.NucleicAcidsResearch.34:407-416.
7．ZhangD.-H.,ZhouB.,HuangY.,XuL.-X.andZhouJ.-Q.(2006).ThehumanPif1helicase,apotentialEscherichiacoliRecDhomologue,inhibitstelomeraseactivity.NucleicAcidsResearch.34:1393-1404
8．ChenY.-B.,YangC.-P.,LiR.-X.,ZengR.andZhouJ.-Q.(2005).Def1pisinvolvedintelomeremaintenanceinbuddingyeast.JBiolChem280:24784-24791.
9．LiaoX.-H.,ZhangM.-L.,YangC.-P.,XuL.-X.andZhouJ.-Q.(2005)CharacterizationofrecombinantSaccharomycescerevisiaetelomerasecoreenzymepurifiedfromyeast.BiochemicalJournal390:169-176
10．ZhouJ.-Q.*,QiH.*,SchulzV.P.,MateyakM.K.,MonsonE.K.,ZakianV.A..(2002)Schizosaccharomycespombepfh1(+)EncodesanEssential5'to3'DNAHelicaseThatIsaMemberofthePIF1SubfamilyofDNAHelicases.MolBiolCell.13:2180-91.*Co-firstauthor
10.IvessaA.S.*,ZhouJ.-Q.*,SchulzV.P.,MonsonE.K.,ZakianV.A..(2002)SaccharomycesRrm3p,a5'to3'DNAhelicasethatpromotesreplicationforkprogressionthroughtelomericandsubtelomericDNA.GenesDev.16:1383-96.*Co-firstauthor
11.ZhouJ.-Q.;Monson,E.K.;Teng,S.-C.;Schulz,V.P.;andZakianV.A.(2000).Pif1pHelicase,aCatalyticInhibitorofTelomeraseinYeast.Science.289:771-774.
12.Ivessa,A.S.*;ZhouJ.-Q.*;andZakianV.A.(2000).TheSaccharomycesPif1pDNAhelicaseandthehighlyrelatedRrm3phaveoppositeeffectsonreplicationforkprogressioninribosomalDNA.Cell.100:479-489.*Co-firstauthor
13.ZhouJ.-Q.,He,H.,Tan,C.-K.,Downey,K.M.,andSo,A.G.(1997)ThesmallsubunitisrequiredforfunctionalinteractionofDNApolymerasedeltawiththeproliferatingcellnuclearantigen.NucleicAcidsRes.27:1094-1099.
14.ZhouJ.-Q.,Tan,C-K.,So,A.G.,andDowney,K.M.(1996).PurificationandcharacterizationofthehumancatalyticsubunitofhumanDNApolymerasedeltaexpressedinbaculovirus-infectedinsectcells.J.Biol.Chem.271:29740-29745
