在岗研究生导师情况介绍
所系名称植生生态研究所
性别男
专业名称微生物学
技术职务研究员
行政职务无
Mail地址cswang@sibs.ac.cn
指导博士
生总数1指导硕士
生总数0已毕业学生通讯地址上海市枫林路300号
目前博士
生数6目前硕士
生数2目前在校生邮政编码200032
研究方向昆虫病理学；真菌分子生物学
研究工作1.组学研究：测定金龟子绿僵菌、蝗绿僵菌、蛹虫草及冬虫夏草基因组，并进行高通量转录组研究，揭示昆虫真菌侵染的基因对策；2.昆虫病原真菌致病基因功能研究：主要以金龟子绿僵菌和球孢子白僵菌为对象，克隆、鉴定并分析虫生真菌在昆虫体表入侵及体内定殖阶段涉及附着胞形成、体壁穿透及抵抗昆虫宿主免疫相关的基因种类及功能；3.真菌-昆虫相互作用的分子机制：以激光微切割、高通量测序及基因芯片等技术研究虫生真菌与模式昆虫（家蚕或果蝇）相互作用时病原-宿主的基因表达特征，探索潜在的基因-基因作用模式；4丝状真菌菌种退化、衰老的分子机理：结合以模式丝状真菌构巢曲霉为对象，从转录组、蛋白组及基因功能研究等水平分析虫生真菌角变化、产孢或虫草子实体产生能力下降或丧失的分子机理；5.虫草菌发育生物学及活性成份代谢途径：以蛹虫草为对象研究子实体发育的分子调控机理及活性成份代谢合成途径等。
实验室网页：http://sippe.ac.cn/wangcs/
获奖情况2012年度国家杰出青年基金资助；
2012年度中国科学院“百人计划”终期评估优秀；
2009年度国家科技进步二等奖（2009-J-202-2-01-R02）；
2008年度安徽省科技一等奖（2008-1-R6）；
2005年度安徽省科技一等奖（2005-1-R4）。
指导研究
生情况
个人简介1989.9–1993.7安徽农业大学植保系,学士.
1993.9–1996.7安徽农业大学林学系,硕士.
1998.9–2001.7中国农业大学微生物系,博士.
1999.8–2000.9英国UniversityofWalesSwansea访问学者.
2001.7-2003.12英国UniversityofWalesSwansea博士后研究.
2004.1-2006.8美国UniversityofMaryland博士后研究.
2006.9-应聘为中国科学院植物生理生态研究所“百人计划”课题组长，研究员
近期论文1.WangB.,KangQ.J.,LuY.Z.,BaiL.Q.andWangC.S.*2012.UnveilingthebiosyntheticpuzzleofdestruxinsinMetarhiziumspecies.ProceedingsoftheNationalAcademyofSciencesUSA,109(4):1287-1292.
2.ShangY.,DuanZ.B.,HuangW.,GaoQ.,WangC.S.*2012.ImprovingUVresistanceandvirulenceofBeauveriabassianabygeneticengineeringwithanexogenoustyrosinasegene.JournalofInvertebratePathology,109(1):105-109.
3.ZhengP.,XiaY.L.,XiaoG.H.,XiongC.H.,ZhangS.W.,Zheng,H.J.,HuangY.,ZhouY.,WangS.Y.,ZhaoG.-P.,LiuX.Z.,St.LegerR.J.andWangC.S.*2011.GenomesequenceoftheinsectpathogenicfungusCordycepsmilitaris,avaluedtraditionalChinesemedicine.GenomeBiology,12(11):R116.
4.GaoQ.,JinK.,YingS.-H.,ZhangY.J.,XiaoG.H.,ShangY.F.,DuanZ.B.,HuX.,XieX.Q.,ZhouG.,PengG.X.,LuoZ.B.,HuangW.,WangB.,FangW.G.,WangS.B.,ZhongY.,MaL.-J.,St.LegerR.J.,ZhaoG.P.,PeiY.,FengM.G.*,XiaY.X.*andWangC.S.*.2011.GenomesequencingandcomparativetranscriptomicsofthemodelentomopathogenicfungiMetarhiziumanisopliaeandM.acridum.PLoSGenetics,7(1):e1001264.
5.WangS.B,Fang,W.G.,Wang,C.S.andSt.Leger,R.J.2011.Insertionofanesterasegeneintoaspecificlocustpathogen(Metarhiziumacridum)enablesittoinfectcaterpillars.PLoSPathogens7(6):e1002097.
6.St.Leger,R.J.,WangC.S.andFangW.G.2011.Newperspectivesoninsectpathogens.FungalBiologyReviews,25:84-88.
7.XiongC.H.,XiaY.L.,ZhengP.,ShiS.H.andWangC.S.*2010.Developmentalstage-specificgeneexpressionprofilingforamedicinalfungusCordycepsmilitaris.Mycology,1(1):25-66.
8.An,Z.Q.,Wang,C.S.,Liu,X.Z.andBennettJ.W.2010.China'sfungalgenomicsinitiative:awhitepaper.Mycology,1(1):1-8.
9.StLegerR.J.*,WangC.S.*2010.Geneticengineeringoffungalbiocontrolagentstoachievegreaterefficacyagainstinsectpests.AppliedMicrobiologyandBiotechnology85,901–907.
10.DuanZ.B.,ShangY.F.,GaoQ.,ZhengP.andWangC.S*.2009.AphosphoketolaseMpk1ofbacterialoriginisadaptivelyrequiredforfullvirulenceintheinsect-pathogenicfungusMetarhiziumanisopliae.EnvironmentalMicrobiology,11(9):2351-2360.
11.Duan,Z.B.,GaoQ.,Lv,D.D.,Shi,S.H.,Butt,T.M.andWangC.S.*2009.AppressorialdifferentiationanditsassociationwithcAMPintheinsectpathogenicfungusMetarhiziumanisopliae.Mycosystema,28(5):712-717.
12.ButtT.M.*,BenElHadjN.,SkrobekA.,RavensbergW.J.,WangC.S.,LangeC.M.,VeyA.,ShahU.K.andDudleyE.2009.Massspectrometryasatoolfortheselectiveprofilingofdestruxins;theirfirstidentificationinLecanicilliumlongisporum.RapidCommunicationsinMassSpectrometry23(10):1426-34.
13.St.Leger,R.J.andWang,C.S.2009.Entomopathogenicfungiandthegenomicsera.In:Stock,S.P.,Vandenberg,J.,Glazer,I.andBoemare,N.eds.InsectPathogens:MolecularApproachesandTechniques.Oxfordshire:CABIPublishing,pp,365-400.
14.LuD.D.,Pava-RipollM.,LiZ.Z.andWangC.S*.2008.InsecticidalevaluationofBeauveriabassianaengineeredtoexpressascorpionneurotoxinandacuticledegradingprotease.AppliedMicrobiologyandBiotechnology81(3):515-522.
15.LiL.,PischetsriederM.,St.LegerR.J.,WangC.S*.2008.AssociatedlinksamongmtDNAglycation,oxidativestressandcolonysectorizationinMetarhiziumanisopliae.FungalGeneticsandBiology,45(9):1300-1306.
16.WangC.S.*,DuanZ.B.andStLegerR.J.*2008.TheMOS1osmosensorofMetarhiziumanisopliaeisrequiredforadaptationtoinsecthosthemolymph.EukaryoticCell7(2):302-309.
17.Pava-RipollM,PosadaFJ,MomenB,WangC.S.,StLegerR.*2008.Increasedpathogenicityagainstcoffeeberryborer,Hypothenemushampei(Coleoptera:Curculionidae)byMetarhiziumanisopliaeexpressingthescorpiontoxin(AaIT)gene.JournalofInvertebratePathology99:220–226.
18.WangC.S.*andStLegerR.J.*2007.Ascorpionneurotoxinincreasesthepotencyofafungalinsecticide.NatureBiotechnology25(12):1455-1456.
19.WangC.S.*andStLegerR.J.*2007.TheMetarhiziumanisopliaeperilipinhomologMPL1regulateslipidmetabolism,appressorialturgorpressureandvirulence.TheJournalofBiologicalChemistry282(29):21110-21115.
20.WangC.S.andStLegerR.J.*2007.TheMAD1adhesinofMetarhiziumanisopliaelinksadhesionwithblastosporeproductionandvirulencetoinsects,andtheMAD2adhesinenablesattachmenttoplants.EukaryoticCell6(5):808-816.
21.GottarM.,GobertV.,Matskevich.A.A.,ReichhartJ.M.,WangC.S.,ButtT.M.,BelvinM.,HoffmannJ.A.andFerrandonD.*2006.DualDetectionofFungalInfectionsinDrosophilaviaRecognitionofGlucansandSensingofVirulenceFactors.Cell127(7):1425-1437.
22.WangC.S.andStLegerR.J.*2006.AcollagenousprotectivecoatenablesMetarhiziumanisopliaetoevadeinsectimmuneresponses.ProceedingsoftheNationalAcademyofSciencesUSA103(17):6647-6652.
23.Butt,T.M.,WangC.S.,ShahF.A.andHallR.2006.Degenerationofentomogenousfungi.In:AnEcologicalandSocietalApproachtoBiologicalControl,editedbyJörgenEilenbergandHeikkiHokkanen.Springer,theNetherlands.pp.213-226.
24.WangC.S.*,TypasM.A.andButtT.M.2005.Phylogeneticandexon-intronstructureanalysisoffungalsubtilisins:supportforamixedmodelofintronevolution.JournalofMolecularEvolution60(2):238-246.
25.WangC.S.,HuG.andSt.LegerR.J.*2005.DifferentialgeneexpressionbyMetarhiziumanisopliaegrowinginrootexudateandhost(Manducasexta)cuticleorhemolymphrevealsmechanismsofphysiologicaladaptation.FungalGeneticsandBiology42(8):704-718.
26.WangC.S.andStLegerR.J.*2005.DevelopmentalandtranscriptionalresponsestohostandnonhostcuticlesbythespecificlocustpathogenMetarhiziumanisopliaevar.acridum.Eukaryoticcell4(5):937-947.
27.WangC.S.,ButtT.M.andSt.LegerR.J.*2005.ColonysectorizationofMetarhiziumanisopliaeisasignofageing.Microbiology(UK)151(10):3223-3236.
28.Shah,F.A.,WangC.S.andButtT.M.*2005.Nutritioninfluencesgrowthandvirulenceoftheinsect-pathogenicfungusMetarhiziumanisopliae.FEMSMicrobiologyLetters251(2):259-266.
29.WangC.S.*,FanM.Z.,LiZ.Z.andButtT.M.2004.Molecularmonitoringandevaluationoftheapplicationoftheinsect-pathogenicfungusBeauveriabassianainsoutheastChina.JournalofAppliedMicrobiology96(4):861-870.
30.WangC.S.*,SkrobekA.andButtT.M.2004.InvestigationonthedestruxinproductionoftheentomopathogenicfungusMetarhiziumanisopliae.JournalofInvertebratePathology85(3):168-174.
31.DudleyE,WangC.S.,SkrobekA,NewtonR.P.andButtT.M.2004.MassspectrometricstudiesontheintrinsicstabilityofdestruxinEfromMetarhiziumanisopliae.RapidCommunicationsinMassSpectrometry18(21):2577-2586.
32.WangC.S.*,ShahF.A.,PetalN.,LiZ.Z.andButtT.M.2003.Molecularinvestigationongeneticrelatednessandpopulationstructureoftheentomopathogenicfungus,Beauveriabassiana.EnvironmentalMicrobiology5(10):908-915.
33.WangC.S.,LiZ.Z.,TypasM.A.andButtT.M.*2003.NuclearlargesubunitrDNAgroupIintrondistributioninapopulationofBeauveriabassianastrains:phylogeneticimplications.MycologicalResearch107(10):1189-1200.
34.WangC.S.*,SkrobekA.andButtT.M.2003.ConcurrenceoflosingachromosomeandtheabilitytoproducedestruxinsinamutantofMetarhiziumanisopliae.FEMSMicrobiologyLetters226(2),373-378.
35.WangC.S.*,TypasM.A.andButtT.M.2002.Detectionandcharacterisationofpr1genedeficienciesintheinsectpathogenicfungusMetarhiziumanisopliae.FEMSMicrobiologyLetters213(2):251-255.
36.WangC.S.*,LiZ.Z.andButtT.M.2002.Molecularstudiesofco-formulatedstrainsoftheentomopathogenicfungus,Beauveriabassiana.JournalofInvertebratePathology,80(1):29-34.
37.张四维、王兵、王成树*。2011。基于微生物源的抗虫基因发掘。生命科学，23(2):212-215.
38.宁媛媛、尤明生、王成树*。2009。昆虫免疫识别与病原物免疫逃避机理研究进展。昆虫学报，52(5):567-575。
39.吕丁丁、李增智、王成树*。2008。虫生真菌分子致病机理与基因工程改造研究进展。微生物学通报，35(3)：443-449。
