在岗研究生导师情况介绍
所系名称神经科学研究所
性别女
专业名称神经生物学
技术职务研究员
行政职务研究组长
Mail地址hailanhu
指导博士
生总数6指导硕士
生总数0已毕业学生通讯地址岳阳路320号，23号楼102室
目前博士
生数6目前硕士
生数0目前在校生邮政编码200031
研究方向情感和社会行为的神经基础
研究工作Researchinmylabaimstounderstandhowemotionalandsocialbehaviorsareencodedinthebrain,withamainfocusontheneuralcircuitryunderlyingdepressionanddominancehierarchy.Howaredifferentemotionsrepresentedinthebrain?Whereandwhatmolecularchangesoccurinemotionaldisorderssuchasdepression?Howdoesdominancehierarchyarisefrominterplaybetweenactivityofspecificneuralcircuitsandsocialexperienceofanimals?Weareaddressingthesequestionsusingcombinatorialtechniquesincludingimaging,electrophysiology,molecularbiologyandoptogenetic.Wehopetovisualizetheneuralcircuitsthatareactivatedduringthebehaviorofinterest;characterizethefunctionofspecificcircuitsandcellgroupsinbehavior;andestablishthecausalrelationshipbetweentheactivityofneuralcircuitsandbehavioraloutput.Itisourhopethatthesestudieswillprovidenewinsightsintotheneuralcircuitbasisofbehavior,andalsohavetherapeuticimplicationsintreatingemotionaldisorders.Therearecurrentlythreemaindirectionsinthelab:
1.Neuralrepresentationofemotionalvalue
Rewardingandaversiveemotionalstimulievokedistinctpatternsofbehavior.Howdoesthebrainrepresentthesedifferentemotionalvaluesandgeneratecorrespondingbehavioraloutput?Inordertoextractthevaluerepresentationofanemotionalstimulus,wesimultaneouslymaptheneuralensemblesofrewardingandaversiveemotionalstimuli,andcomparetheiractivationpatternsinthesamemousebrain.
2.Molecularandcircuitmechanismofdepression
Thehabenula,anucleiintherewardpathwayandrecentlygarneredalotofattention,encodesthenegativerewardanditshyperactivityhasbeenimplicatedindepression.Weaimtosearchformolecularmechanismsunderlyingthehabenularhyperactivityindepressedanimals.IncollaborationwithDr.JohnYate’slaboratoryattheScrippsInstitute,weperformedahigh-throughputquantitativeproteomicscreentolookformembraneproteinsthatshowalteredexpressionlevelinthehabenulaofcongenitallydepressedrats(fromDr.FritzHenn).Severalproteinsimplicatedinneuronalplasticitywereidentified.Throughthefunctionalcharacterizingofthesecandidatemoleculesinsynapsephysiologyanddepressionbehaviors,wehopetoidentifybiomarkersofdepressionandrevealthekeymolecularmechanismsunderlyingthediseaseetiology.
3.Neuralcircuitmechanismofsocialhierarchy
Dominancehierarchyisafundamentalorganizingmechanismformostsocialanimals.Thesocialeconomicstatushasbeenidentifiedasthesinglestrongestpredictorofhealth.Inarecentwork(Science,2011),weexploredthecircuitryfordominancehierarchybysynapticperturbationinthemedialprefrontalcortex(mPFC),acandidatebrainregionexplicitlyimplicatedinsocialcognition.Weestablishedthatsocialrankinmiceistransitive,relativelystable,andhighlycorrelatedamongdifferentbehavioralmeasures.Furthermore,thehierarchicalstatusofmicecouldbechangedfromdominanttosubordinate,orviceversa,byviralmanipulationofthesynapticstrengthinmPFC.WearecurrentlyusingmolecularandoptogenetictoolstodelineatethemPFCdownstreamcircuitryinvolvedindominancehierarchy.
获奖情况2010浦江人才计划
2009百人计划
2003-2006DamonRunyonCancerResearchFoundationPostdoctoralFellowship
2002InternationalBrainOrganizationFellowshipforWoodsHoleNeurobiologyCourse
1997－2002HowardHughesMedicalInstitutePredoctoralFellowship
指导研究
生情况
个人简介胡海岚博士1996年毕业于北京大学生物系，获生物化学和分子生物学专业学士。随后在加州大学伯克利分校师从CoreyGoodman博士，于2002年获得神经生物学方向博士学位。2003－2004年和2004－2008年期间分别在美国弗吉尼亚大学JuliusZhu博士的实验室和冷泉港实验室RobertoMalinow博士的实验室进行博士后工作。于2008年12月加入中国科学院神经科学研究所，担任神经环路与行为可塑性研究组组长。胡海岚博士主要从事情绪与社会行为的分子与神经环路机制研究。
Dr.HailanHuistheHeadoftheLaboratoryofNeuralCircuitandBehavioralPlasticity.Dr.HugraduatedfromBeijingUniversitywithaB.S.degreeinBiochemistry&MolecularBiology(1996).ShepursuedherPh.D.degreeinneuroscienceatUniversityofCaliforniaatBerkeley,whereshewasastudentofProf.CoreyGoodman,workingonrepulsiveaxonguidance.AftercompletingPhD(2002),sheconductedpostdoctoralresearchwithDr.JuliusZhuatUniversityofVirginia(2003-2004),andDr.RobertoMalinowatColdSpringHarborLaboratory(2004-2008),workingonmechanismsregulatingAMPAreceptortraffickinginemotionalbehaviorsanddiseasemodels.Dr.HujoinedIONasaPrincipalInvestigatorinDec2008.Forherpastandcurrentresearches,Dr.HuhasreceivedtheHowardHughesPredoctoralFellowship(1997-2002),theDamonRunyonPostdoctoralFellowship(2003-2006),theChineseHundredTalentPlanAward(2009),andShanghaiPujiangTalentAward(2010).
近期论文1.Wang,F,Zhu,J,Zhu,H,Zhang,Q,Lin,Z,Hu,H*(2011)Bidirectionalcontrolofsocialhierarchybysynapticefficacyinmedialprefrontalcortex.Science,334:693-697.[PDF](HighlightedinSciencePerspective“SynapticSwitchandSocialstatus")
2.Hu,H*,QinY*,VanAelst,L,andZhu,JJ.(2008)RassignalingmechanismforimpairedsynapticplasticityandAMPAreceptortraffickinginamousemodeloffragileXsyndrome.JournalofNeuroscience,28(31):7847-62.(*co-firstauthor)
3.Hu,H,RealE,TakamiyaK,Kang,MG,LedouxJ,HuganirR,MalinowR.(2007)EmotionEnhancesMemoryviaNorepinephrineRegulationofAMPAReceptorTrafficking.Cell,131:160-73.(HighlightedinNatureJournalclubandNatureReviewsNeurosci.)
4.HuH*,LiM*,LabradorJ,McEwenJ,LaiEC,GoodmanCS,BashawGJ.(2005)CrossGTPase-activatingprotein(CrossGAP)/VilselinkstheRoundaboutreceptortoRactoregulatemidlinerepulsion.ProcNatlAcadSci,102(12):4613-8.(*co-firstauthor)
5.GodenschwegeTA,HuH,ShanX,GoodmanCSandMurpheyRK.(2002)Semaphorin1FunctionsAsaReceptorandaLigandIntheAssemblyoftheGiantFiberSynapseofDrosophila.NatureNeuroscience,5:1294-301.
6.BashawGJ,HuH,NobesCD,GoodmanCS.(2002)ANovelDBLFamilyRhoGEFPromotesRhoDependentAxonAttractiontotheCNSMidlineinDrosophilaandOvercomesRoboRepulsion.JournalofCellBiology,155(7):1117-1122.(Coverarticle)
7.HuH,MartonTandGoodmanCS.(2001)PlexinBMediatesAxonGuidanceinDrosophilabySimultaneouslyInhibitingActiveRacandEnhancingRhoASignaling.Neuron,32(1):39-51.(HighlightedinthePreviewofNeuron)
8.DriessensMH,HuH,NobesCD,SelfA,JordensI,GoodmanCS,HallA.(2001)Plexin-BsemaphorinreceptorsinteractdirectlywithactiveRacandregulatetheactincytoskeletonbyactivatingRho.CurrentBiology,11(5):339-44.
9.BellocchioEE,HuH,PohorilleA,ChanJ,PickelVMandEdwardsRH.(1998)PresynapticlocalizationofaneuronalNa+dependentinorganicphosphatetransporter.JournalofNeuroscience,18(21):8648-59.
