在岗研究生导师情况介绍
所系名称神经科学研究所
性别男
专业名称神经生物学
技术职务研究员
行政职务研究组长
Mail地址w.wang@ion.ac.cn
指导博士
生总数3指导硕士
生总数3已毕业学生通讯地址中国科学院神经科学研究所上海市岳阳路320
目前博士
生数3目前硕士
生数1目前在校生邮政编码200031
研究方向视觉神经科学
研究工作ResearchInterests
Visualperceptionhasheldaspecialpointoffascinationwithphilosophersandscientistsforthousandsofyears.Whatappearstousaneffortlesstask,theopeningofoureyes,engagesanextensiveandanatomicallycomplexnetworkofbrainareas.Itisthesebrainareaswhichaffordus,asAristotlephrasesit,thedelightandexploratorypowerofseeing.Neuroscientistsareslowlyunravelingthiscomplexitywithaneyetobothpureknowledgeofourdominantsense,andalsoitsgatewaystatustocognitionanddisease.Ourlaboratoryfocusesontheneuralcircuitryandfunctionalorganizationofsomevisualperceptualphenomena.Ourlabbringstogetherarangeofmulti-disciplinarytechniques,includinginvivodualopticalimaging,invivosimultaneousmulti-singleunitrecordingofdifferentcorticalbrainareasalongwithmulti-iontophoreticdrugapplication.Bothanesthetizedandawakeanimalpreparationsarecarriedoutinourlab.
1.Theneuralmechanismsofvisualperceptualillusionandfilling-in:
Visualillusionandfilling-indramaticallyrevealsthedissociationbetweentheretinalinputandthepercept,andraisesfundamentalquestionsabouthowthesetworelatetoeachother.Fillinginoccursbothinnormalandpathologicalvision,anditsspatiotemporalcharacteristicssuggestmultiplelevelsofvisualsysteminteraction.Detailsoftheseneuralinteractionsinearlyvisualareasandbetweenhigherandlowerareasaretheimportantquestionstobestudied.Specifically,ourlaboratoryaskswhatthefunctionalroleofhigherordervisualareasuchasV4/MTinillusoryandkineticcontourperceptionis.
2.Theneuralcircuitryandfunctionorganizationoffeedbackinthecentralvisualsystem:
Oneofthemostinterestingchallengesinvisionthereforeistounraveltheroleoftheseextensivefeedbacksystemsthatparalleltheascendingfeed-forwardpathways.TheroleofLayer6corticalfeedbackcellsinvisualprocessingisofparticularappeal,forLayer6cellsinthevisualcortexsitinacrucialplaceinthecircuitryinvolvedintheearlyprocessingofthevisualinputinhighermammalssuchascatsandprimates.Ourinterestslieinunderstandinghowthesecellsmaygateandmodulatetheinformationflowthroughthevisualhierarchy.
3.Theneuralmechanismsofmotionperception:AfunctionalstudyofinteractionsbetweenV1/V2andMTintheprimate:
Visualmovementsareprocessedprimarilybyamagnocellulardominatedstream(thoughthereisanincreasingappreciationofacontributionbytheparvocellularsystem)throughthelateralgeniculate(LGN),visualcorticesV1/V2,andonintoV5/MT.Howthisintegrationandsegregationofmotionsignalstakesplaceisstillonlypartiallyunderstood.TheroleplayedbyMTinmotionintegrationisthemainfocusofthisstudy.
获奖情况Awards:
1.‘ThehundredPeopleProgram’award,CAS,(2007)
2.TheWellcomeTrustCareerDevelopmentFellowshipAward(2006):
3.LewisRudinAwardfromNewYorkAcademyofMedicineforthemostoutstandinginternationalglaucomapublicationin2005(Cordeiroetal,PNAS2004)
4.PeterAllenTravellingScholarship(2004)fromUMIST
Grants:AsPrincipleInvestigator:
1.‘ThehundredPeopleProgram’AwardGrant(0713N61231)2007:‘Theneuralcircuitryandfunctionorganizationoffeedbackinthecentralvisualsystem’.GrantTotal:2millionChineseYuan/4years.
2.RoyalSocietyResearchGrant(R2007/s)2007:‘Thespatio-temporaldynamicsofthe‘initialdip’intheBOLDresponseforfunctionalbrainimaging’.SoloApplicant.GrandTotal:£12,968.00/year
3.TheWellcomeTrustProjectGrant(W078418)2006:‘‘thecircuitryofmotionperception:AfunctionalstudyofinteractionsbetweenV1andMTintheprimate’’.SoloApplicant.GrandTotal:£202,000.00/3years.
SelectedthroughthepeerreviewedgrantproposalschemeoftheWellcomeTrust,andinterviewedbytheWellcomeTrustBasicScienceCommittee.‘‘TheWellcomeTrustlaunchesthisschemetosupportthebestscientiststobroadenandstrengthentheirresearchfromearlystagestofurtheralongthecareerpath’’(WordscutfromtheWellcomeTrustwebpage).
指导研究
生情况
个人简介王伟博士，男，1993年于中国科学技术大学获得理学硕士学位，1993-1995年在北京医科大学儿童视觉研究中心任助理研究员，1998年于中国科学技术大学获得理学博士学位。1998-2006年先后在伦敦大学学院眼科所视觉神经科学系、曼切斯特理工大学检眼科学与神经科学系以及曼切斯特大学生命科学系从事博士后研究，2006-2007年任曼切斯特大学生命科学系独立研究员（TheWellcomeTrustCareerDevelopmentFellowshipAward，Independent,TenureTrack）。2007年起任中国科学院上海生命科学研究院神经科学研究所研究员、博士生导师、研究组组长。
近期论文SelectedPublications:
1.SchiesslI,WangWandMcLoughlinN(2008).Fasthemodynamicresponsesrevealedbymulti-spectralopticalimaging.Neuroimaging，39:634-646
2.AndolinaIM,JonesHE,WangWandSilitoAM(2007).Cortico-thalamicFeedbackEnhancesStimulusResponsePrecisionintheVisualSystem.PNASJan30,7,vol.104,no.5:1685-16901.
3.WangW,JonesHE,AndolinaIM,SaltTE&SillitoAM(2006).Functionalalignmentoffeedbackeffectsfromvisualcortextothalamus.NatureNeurosci.Oct;9(10):1330-6.
4.CordeiroMF,GuoL,LuongV,HardingG,WangW,JonesHE,MossSE,SillitoAMandFitzkeFW(2004).Realtimeimagingofsinglenervecellapoptosisinretinalneurodegeneration.PNASVol.101No.36,13352-13356.
5.ShouTD,LiuJ,WangW,ZhouYFandZhaoKX(2003).DifferentialDendriticShrinkageofαandβRetinalGanglionCellsinCatswithChronicGlaucoma.Invest.Ophthalmol.&Vis.Sc.44:3005-3010.
6.JonesHE,WangWandSillitoAM(2002).SpatialorganisationandmagnitudeoforientationcontrastinteractionsinprimateV1.JNeurophysiol88(5):PP2796-2808.
7.JonesHE,GrieveKL,WangWandSillitoAM(2001).SurroundSuppressioninPrimateV1.JNeurophysiol,Vol.86,PP2011-2028.
8.ShouTD,WangWandYuHP(2000).Orientationbiasedextendedsurroundofthereceptivefieldofcatretinalganglioncells.Neuroscience,Vol.98,No.2,PP207-212(oneofMyPhDthesiswork).
9.WangWandShouTD(2000).Patternadaptationofrelaycellsinthelateralgeniculatenucleusofbinocularandmonocularvision-deprivedcats.ActaPhysiologicaSinica,52(3),PP230-234.(oneofMyPhDThesiswork).
10.WangW,YangYP,YuHP,ZhouYFandShouTD(1999).Binocularresponsepropertiesofthedorsallateralgenicularnucleusneuronsinthemonoculareyelidsuturedcats.ActaBiophysicaSinica,Vol.15No.3PP475-481.(oneofMyPhDThesisWork).
11.ZhouYF,WangW,RenBandShouTD(1994):ReceptiveFieldPropertiesofCatGanglionCellsDuringShort-TermIOPElevation.Invest.Opthalmol.&Vis.Sci,Vol35,NO.6,PP2758-2764(MyMScthesiswork)
