在岗研究生导师情况介绍
所系名称神经科学研究所
性别男
专业名称神经生物学
技术职务研究员
行政职务研究组长
Mail地址yzwang@ion.ac.cn
指导博士
生总数18指导硕士
生总数2已毕业学生通讯地址上海岳阳路320号
目前博士
生数8目前硕士
生数1目前在校生邮政编码200031
研究方向神经信号转导研究
研究工作神经信号转导在神经活动调节中起重要的作用，G蛋白和蛋白激酶级联反应是信号转导的关键。目前正在进行的研究项目包括中枢神经系统中主要的兴奋性神经递质，谷氨酸激活抑制性G蛋白（Gi）的机制及结果，PI3和MAP激酶级联反应在预防或诱导神经调亡过程中潜在作用的研究。借助于分子生物学、细胞生物学和生物化学多种方法，在原代神经元培养、细胞系和动物模型进行多层次的研究
获奖情况
指导研究
生情况指导硕博士生总数18，目前在学硕博士生人数8
个人简介1982年毕业于中国医科大学医疗系，
1991年在加拿大拉瓦尔大学获得博士学位，
1991-1994年分别在法国尼斯和美国凯斯西北大学做博士后。
以后分别在加拿大国家研究院(1994-1999)
美国托马斯杰弗逊大学(1999-2001)供职。
2001年应聘至中科院神经科学研究所担任研究组长。
近期论文1．Wang,YZ.,Simonson,MS.,Pouyssegur,J.andDunn,MJ.(1992)Endothelinrapidlystimulatesmitogen-activatedproteinkinaseactivityinratmesangialcells.Biochem.J.287,589-594
2.Simonson,MS.,Wang,YZ.,Jones,JM.andDunn,MJ.(1992)ProteinkinaseCregulatesactivationofmitogen-activatedproteinkinaseandinductionofproto-oncogenec-fosbyendothelin-1.J.Cardiovas.Pharma.20,S29-S32
3.Wang,YZ.,Pouyssegur,J.andDunn,MJ.(1993)Endothelinstimulatesmitogen-activatedproteinkinasep42activitythroughthephosphorylationofthekinaseinratmesangialcells.J.Cadiovas.Pharma.22,S164-S167
4.Schramek,H.,Wang,YZ.,Konieczkowski,M.,Rose,PM.,Sedor,JR.andDunn,MJ.(1994)Endothelin-1stimulatescytosolicphospholipaseA2inChinesehamsterovarycellsstablyexpressingthehumanETAorETBreceptorsubtype.Biochem.Biophys.Res.Commun.199,992-997
5.Wang,YZ.,Pouyssegur,J.andDunn,MJ.(1994)Endothelinstimulatesmitogen-activatedproteinkinaseactivityinmesangialcellsthroughETA.JASN.5,1074-1080.
6.Wang,YZ.,Rose,PM.,Webb,M.andDunn,MJ.(1994)Endothelinsstimulatethemitogen-activatedproteinkinasecascadethrougheitherETAorETB.Am.J.Physiol.267(CellPhysiol.36),C1130-C1135.
7.Schramek,H.,Wang,YZ.,Konieczkowski,M.,Simoson,M.andDunn,MJ.(1994)Endothelin-1stimulatescytosolicphospholipaseA2activityandgeneexpressioninratglomerularmesangialcells.KidneyInter.46,1644-1652
8.Wang,YZ.andDurkin,J.(1995)AMPA,butnotNMDA,activatesMAPkinasethroughG-proteinsubunitsinratcorticalneurons.J.Biol.Chem.270,22783-22787.
9.Wang,YZ.,Schramek,H.andDunn,MJ.(1996)Cytosolicandnuclearmitogen-activatedproteinkinasesareregulatedbytwodistinctmechanisms.Exp.Cell.Res.225,382-388
10.Coroneos,E.,Wang,YZ.,Panuska,JR.,Templeton,DJ.andKester,M.(1996)Sphingolipidmetabolitesdifferentiallyregulateextracellularsignal-regulatedkinase(ERK)andstress-activatedproteinkinase(SPAK)cascades.Biochem.J.316,13-17.
11.Testolin,L.,Carson,C.,Wang,YZ.,Walker,PR.Armato,UandSicroska,M.(1997)JunandJNKkinaseareactivatedinthymocytesinresponsetoVM26andradiationbutnotglucocorticoids.Exp.CellRes.230,220-232.
12.Wang,YZ.,Samll,D.,Stanimirovic,D.,Morley,P.andDurkin,J.(1997)AMPA-mediatedregulationofaGi-proteinincorticalneurons.Nature389,502-504.
13.Mandal,A.,Wang,YZ.,Ernsberger,P.andKester,M.(1997)Il-1-inducedether-linkeddiglyceridesinhibitcalcium-insensitivePKCisotypes:implicationsforgrowthsenescence.J.Biol.Chem.272,20306-20311.
14.Tauskela,JS.,Chavravarty,B.,Murray,C.,Wang,YZ.,Coma,T.,Hogen,MJ.,Hakim,AM.andMorley,P.(1999)Evidencefromculturedratcorticalneuronsofdifferencesinthemechanismofischemicpreconditioningofbrainandheart.BrainRes.827,143-151
15.Bourbon,NA.,Berkey,D.,Wang,YZ.andKester,M.(2001)CeramidedifferentiallyregulatesPKC/MAPKinteraction:Implicationsforgrowtharrest.Amer.J.Physiol.(CellPhysiol.)280,C1403-C1411
16.Wang,YZ.,Guan,J.,Wang,HY.,Wang,Y.,Leeper,D.andIliakis,G.,etal(2001)RegulationofDNAreplicationafterheatshockbyRPA-nucleolininteractions.J.Biol.Chem.276,20579-20588
17.Regan,RF,WangYZandGuo,YP.(2002)Activationofextracellularregulatedkinasespotentiatesheme-mediatedoxidativeinjurytoastrocytes.J.Neurochem.79,545-555
18．Ye,YZ.,Xi,W.,Peng,YQ.,Wang,YZ.,andGuo,AK.(2004)Long-termbutnotshort-termblockadeofdopaminereleaseinDrosophilaimpairsorientationduringflightinavisualattentionparadigm.Eur.J.Neurosci.20,1001-1007.
19．Li.Y,Jia,YC,Cui,K,Li,N,Zheng,ZY,Wang,YZ,Yuan,XB(2005)EssentialroleofTRPCchannelsintheguidanceofnervegrowthconebyBDNF.Nature.434,894-898
20.Tao,YM.,Zeng,R.,Shen,B.,Jia,JM.,andWang,YZ.(2005)NeuronaltransmissionstimulatesthephosphorylationofKv1.4channelatSer229throughproteinkinaseA.J.Neurochem.94，1512-1522.
21.Tao,YM.,Yan,D.,Yang,QY.andWang,YZ.(2006)LowK+promotesNF-BDNAbindinginneuronalapoptosisinducedbyK+loss.Mol.CellBiol.26(3),1038-1050
22.Yan,D.,Gou,L.andWang,YZ.(2006)RequirementofdendriticAktdegradationbytheubiquitinproteasomesystemforneuronalpolarity.J.CellBiol.174415-424
23．Yang,QY.,Yan,D.andWang,YZ.(2006)TheK+RegulatesDNABindingoftranscriptionfactorstocontrolgeneexpressionrelatedtoneuronalapoptosis.NeuroReport.17(11):1199-204
24.Huang,CX.,Jia,YC.,Yang,SL.,Chen,B.,Sun,HW.,Shen,F.andWang,YZ.(2007)CharacterizationofZNF23,aKRAB-containingproteinthatisdownregulatedinhumancancersandinhibitscellcycleprogression.Exp.CellRes.313(2):254-263.
25.Guo,L.andWang,YZ.(2007)Glutamatestimulatesglutamatereceptorinteractingprotein1degradationbyubiquitin-proteasomesystemtoregulatesurfaceexpressionofGluR2.Neuroscience145:100-109
26.Wang,ZH.,Shen,B.,Yao,HL.,Jia,YC.,Jin,R.,Feng,YJ.andWang,YZ.(2007)Blockageofintermediate-conductance-Ca2+-activatedK+channelsinhibitsprogressionofhumanendometrialcancer.Oncogene26,5107-5114
27.Jia,YC.,Zhuo,J.,Tai,YL.andWangYZ.(2007)TRPCchannelspromotecerebellargranuleneuronsurvival.NatureNeuroscience10，559-567.
28．Wang,WY.,Yang,Y.,YingCY.,Li,WM.,Ruan,HL.,Zhu,XN.,You,Y.,Han,YF.,Chen,RZ.,WangYZ.,Li,MT.(2007)Inhibitionofglycogensynthasekinase-3protectsdopaminergicneuronsfromMPTPtoxicity.Neurophanrmacology(52)1678-1684
29.Shen,B.Zhou,KC.,Yang,SL.,Xu,TL.andWang,YZ.(2008)TheKv4.2MediatesExcitatoryActivity-DependentRegulationofNeuronalExcitabilityinRatCorticalNeurons.J.Neurochem.105,773-783
30.Zhou,J.,Du,WL.,Zhou.,KC.,Tai,YL.,Jia,YC.,andWangYZ.(2008)CriticalroleofTRPC6channelsintheformationofexcitatorysynapses.NatureNeuroscience.11，741-743.
31.Tai,YL.,Feng,SJ.,Du,WL.,Zhang,XX.,andWangYZ.(2008)TheTRPC6promotesdendriticgrowthviatheCaMIV-CREBpathway.J.CellSci.121，2301-2307.
32.Huang,C.,Yang,S.,Ge,R.,Sun,H.,Shen,F.,andWang,YZ.(2008)ZNF23inducesapoptosisinhumanovariancancercells.CancerLett.266，135-143.
33.Yao,YY.,Ding,X.,Jia,JC.,Huang,CX.,Wang,YZ.,andXu,YH.(2008)Anti-tumoreffectof-elemeneinglioblastomacellsdependsonp38MAKactivation.CancerLett.264，127-134.
34．Yang，SL.,Cao,Q.,Zhou,KC.,Feng,YJandWang,YZ.(2009)TransientReceptorPotentialChannelC3contributestotheprogressionofhumanovariancancer.Oncogene28,1320-1328
35.Yao,HL.,Zhou,KC.,Yan,D.,Li,MT.andWang,YZ.(2009)TheKv2.1channelsmediateneuronalapoptosisinducedbyexcitotoxicity.J.Neurochem.108,909-919
36．Ge,RL.,Tai,YL.,Sun,YY.,Zhou,KC.,Yang,SL.,Cheng,TL.,Zou,QF.,Shen,F.andWang,YZ.(2009)CriticalroleofTRPC6channelsinVEGF-mediatedangiogenesis.CancerLett.283,43-51
37．Cai,R.,Ding,X.,Zhou,KC.,Shi,Y.,Ge,RL.,Ren,G.,Jin,YN.andWang,YZ.(2009)BlockadeofTRPC6channelsinducedG2/Mphasearrestandsuppressedgrowthinhumangastriccancercells.Intl.J.Cancer125,2281-2287
38.Yuan,ZM.,Gong,SF.,Luo,JY.,Zheng,ZH.,Song,B.,Ma,SS.,Guo,JL.,Hu,C.,Thiel,G..,Vinson,C.,Hu,CD.,Wang,YZ.andLi,MT.(2009)OpposingRolesforATF2andc-Fosinc-Jun-MediatedNeuronalApoptosis.Mol.Cell.Biol.29,2431–2442_
39．Shi,Y.,Ding,X.,He,ZH.,Zhou,KC.,Wang,Q.andWang,YZ.(2009)CriticalroleofTRPC6inG2phasetransitionanddevelopmentofhumanesophagealcancer.Gut58，1443-1450.
40．Ding,X.,He,ZH.,Zhou,KC.,Cheng,J.,Yao,HL.,Cai,R.,Jin,YN.andWang,YZ.(2009)EssentialroleofTRPC6channelsinG2phaseprogressionandgliomadevelopment.J.Ntal.CancerInst.InRevision.
Review
1.Tai,YL.,Feng,SJ.,Du,WL.,andWangYZ.(2009)FunctionalrolesofTRPCchannelsinthedevelopingbrain.PlugersArch.Eur.J.Physiol.458:283-289
