在岗研究生导师情况介绍
所系名称神经科学研究所
性别男
专业名称神经生物学
技术职务研究员
行政职务研究组长
Mail地址zuorenwang@ion.ac.cn
指导博士
生总数0指导硕士
生总数0已毕业学生通讯地址上海岳阳路320号
目前博士
生数0目前硕士
生数0目前在校生邮政编码200031
研究方向神经环路及动物行为
研究工作
ResearchInterestsandfuturedirections
Thesensorysystemsofanimaldetectbothphysicalandchemicalcuesintheenvironmentandplaycriticalrolesinindividualbehaviors(suchasfeeding,avoidingandescaping)andsocialbehaviors(suchasmating,caringandaggression).Becauseofitssimplicityandamenabilitytomolecular,geneticandelectrophysiologicalmanipulations,thesensorysystemsofthefruitfly--Drosophilamelanogasterprovideanidealexperimentalsystemtostudyhowinformationoftheexternalenvironmentisrepresented,processedandintergratedinthebrain.Theresearchinourlabisfocusedonunderstandinghowanimalbehaviorisdeterminedbysensoryinputsatthelevelofneuralcircuitry.
Sensorysignalprocessingintheflybrain.
Althoughtheprojectionpatternsoftheprimarysensoryneurons(orthesecondaryneurons)ofseveralsensorysystemsofthefruitflyaremapped,therestofthesensory-tomotorcircuitsislargelyunknown.Completelydissectingthesensoryneuralcircuitswillprovideinsighttoourprofoundunderstandingoftheorganizationofthesensoryprocessingcomponentsandthemechanismsofanimalbehavior.Aseriesofexperimentscombiningmolecular,genetic,andbehavioralapproachesaredesignedtoelucidatethesensoryneuralcircuit.Furthermore,inordertomechanisticallyunderstandhowexternalinformationisencodedinthesensoryprojectionpatternsandinhigherbraincenters,wehavetorelatetheanatomyofthesensorysystemstotheactivitiesofthesensorycircuits.Electrophysiologicalrecordingwillbeconductedintheflybraintocollectdataforhelpingustounderstandthemechanismofsensorycodingandprocessing.
Integrationofsensoryinputsintheflybrain
Manysensorysystemsareinvolvedinasingleanimalbehavioralresponsetotheenvironment.Forinstance,thefeeding,matingoravoidingbehaviorsofthefruitflyaremediatedbythesummationofdifferenttypesofstimuli,suchasthesmell,taste,textureandshapeofanobject.Thus,itisreasonabletopredictthatthereareanatomicalstructuresintheflybrainresponsibleforthecross-talkofdifferenttypesofsensorysignals,andtothecoordinationofmotoroutputs.Olfaction-TasteorOlfaction-Taste-Visioncross-modalitybehaviorparadigms,inparalleltoelectrophysiologicalrecording,willbeestablishedtounderstandthemechanismunderlyingtheintegrationofdifferentsensoryinputs.
Behavioralgeneticsofthemechanismofanimalbehavior.
Geneticscreeningisapowerfulmeanstoidentifycandidategenesthatareinvolvedincomplexanimalrecognitionbehaviors,suchaslearningandmemory.Althoughthefocusofourresearchistounderstandhowanimalbehaviorisdeterminedattheneuralcircuitrylevel,identificationofgenesinvolvedinaspecificanimalbehaviorwillbegreatlyhelpfultousinunderstandingthefunctionandorganizationoftheneuralcircuits.Largescalemutagenesis,couplewithbehavioralscreeningwillbecarriedouttoidentifycandidategenesthatarespecificallyinvolvedincertaintypesofanimalbehaviors.Studiesonhowthosecandidategenescouldinfluenceanimalbehaviorwillbefollowed.
获奖情况
指导研究
生情况指导硕博连读生四名
个人简介
PrincipleInvestigator(2005--)
InstituteofNeuroscience
ChineseAcademyofScienc
Post-Doc.(2002-2005)
UniversityofCaliforniaatBerkeley
Berkeley,California
Ph.D.inBiochemistry(2001)
Rutgers--theStateUniversityofNewJersey
NewBrunswick/Piscataway,NewJersey,USA
M.S.inBiochemistry(1997)
ShanghaiInstituteofBiochemistry
ChineseAcademyofScience
B.S.inBiochemistry(1994)
EastChinaUniversityofScienceandTechnology
近期论文Zhang,W.,Ge,W.,andWang,Z.(2007)AtoolboxforlightcontrolofDrosophilabehaviorsthroughChannelrhodopsin2-mediatedphotoactivationoftargetedneurons.Eur.J.Neurosci.26:2405-2416.
Wang,Z.,Singhvi,A.,Kong,P.,Scott,K.(2004).TasterepresentationsintheDrosophilabrain.Cell.117:981-991.
Rodgers,N.D.,Wang,Z.andKiledjian,M.(2002).Regulateda-globinmRNAdecayisacytoplasmiceventproceedingthrough3'to5'exosome-dependentdecapping.RNA.8:1526-1537.
Wang,Z.*,Jiao,X*.,Carr-Schmid*,A.andKiledjian,M.(2002).ThehDcp2proteinisamammalianmRNAdecappingenzyme.Proc.Natl.Acad.Sci.USA.99:12663-12668.
Rodgers,N.,Wang,Z.,andKiledjian,M.(2002).CharacterizationandPurificationofaMammalianEndoribonucleaseSpecificforthea-GlobinmRNA.J.Biol.Chem.277:2597-2604.
Wang,Z.,andKiledjian,M.(2001).FunctionalLinkbetweentheMammalianExosomeandmRNADecapping.Cell.107:751-762.
WenC.,WangZ.,DuP.,GanR.,andZhuS.(2001).SecretionexpressionofrecombinantglucagoninEscherichiacoli.ScienceinChinaSeriesC.4:233-240.
Barnhart,B.,.Kosinski,P.,Wang,Z.,Ford,G.S.,Kiledjian,M.andCovey,L.R.(2000).IdentificationofaComplexthatbindstotheCD1543´UTR:ImplicationsforaRoleinMessageStabilityduringTcellActivation.J.Immunology.165:4478-4486.
Wang,Z.,andKiledjian,M.(2000).ThePoly(A)-BindingProteinandanmRNAStabilityProteinJointlyRegulateanEndoribonucleaseActivity.Mol.Cell.Biol.20:6334-6341.
Wang,Z.,andKiledjian,M.(2000).IdentificationofanErythroid-EnrichedEndoribonucleaseActivityInvolvedinSpecificmRNACleavage.EMBOJ.19:295-305.
Wang,Z.,Day,N.,Trifillis,P.andKiledjian,M.(1999).AnmRNAStabilityComplexFunctionswiththePoly(A)-BindingProteintoStabilizemRNAInVitro.Mol.Cell.Biol.19:4552-4560.
