在岗研究生导师情况介绍
所系名称神经科学研究所
性别男
专业名称神经生物学
技术职务研究员
行政职务研究组长
Mail地址yuanxb@ion.ac.cn
指导博士
生总数8指导硕士
生总数3已毕业学生通讯地址上海岳阳路320号
目前博士
生数4目前硕士
生数2目前在校生邮政编码200031
研究方向神经元迁移及其导向机制
研究工作1.Objectives
MylaboratorywassetupinMarch2005.Thelong-termgoalofmylaboratoryistounderstandthemolecularmechanismsunderlyingthepropermigrationanddistributionofdifferenttypesofneuronsindevelopingbrain,oneofthekeystepsforbrainmorphogenesis.Currently,wefocusontheguidancemechanismfortheradialmigrationofcorticalneuronsbydiffusibleguidancefactorsandtheintracellularmolecularmachinerythatdrivestheneuronalmigration.Acombinationofapproachesincludingsingleneuronmigrationassay,embryoelectroporation,tissueculture,molecularmanipulations,andopticalimaging,areusedtotacklethesequestions.Humangeneticstudiesshowedthatmanyneurologicaldisordersarecausedbydefectsinandneuronalmigrationaxonpathfindingduringdevelopment.Thislineofstudywillshedanewlightonthediagnosisandtherapyofthisgroupofdiseases.
2.MainTopics
(1)Guidanceofthecorticalradialmigrationbyextracellularandintracellularfactors
Formationofthelaminarstructureofthemammaliancerebralcortexrequiresawell-coordinatedmigrationofcohortsofpost-mitoticneuronsalongradialglialfibersfromtheventribularzone(VZ)towardssuperficiallayersofthecorticalplate(CP)duringearlydevelopment.Weaimtoclarifywhetherachemotropicguidancemechanismisalsoengagedintheproperradialmigrationandlaminationofcorticalneurons.Intracellularsignalingmechanismsunderlyingtheguidanceofcorticalradialmigrationbydiffusiblefactorsarealsoanalyzed.
(2)Molecularmachineryunderlyingtheneuronalmigrationanditsguidance
Dissociatedcultureofcerebellargranulecellsexhibitsactiveneuronalmigration,andprovidesanexcellentmodelsystemformonitoringthemoleculardynamicsthatcorrelateswiththemigratorybehavioroftheneuron.Wealsotakeadvantageofthelocalratherthanglobalperfusionofguidancefactorsandpharmacologicalagentsatdifferentsub-cellularregionsofmigratingneuronstodissecthowthemotilitiesofdifferentpartsofneuronsaregeneratedandcoordinatedduringneuronalmigration.
获奖情况2003上海市科技启明星
2004全国百篇优秀博士论文
2006杰出青年基金
2007第九届中国青年科技奖
2007国务院特殊津贴
指导研究
生情况2005年毕业博士金明，李燕
2007年毕业博士管沉冰
2008年毕业博士陈罡，崔凯
2009年毕业博士司马健，李宁，赵春涛；硕士刘洋，梁旭俊
2010年毕业硕士李俊涛
个人简介9/1991—6/1995BachelorinBiology,EastChinaNormalUniversity
9/1995—8/1999GraduateStudent,ShanghaiBrainResearchInstitute,CAS
9/1999—2/2000ExchangeStudent,BiologyDepartment,UCSD
3/2000—6/2001Ph.DinNeuroscience,ShanghaiBrainResearchInstitute,CAS
7/2001—11/2002AssistantInvestigator,InstituteofNeuroscience,SIBS,CAS
12/2002—2/2005AssociateInvestigator,InstituteofNeuroscience,SIBS,CAS
3/2005—Investigator,InstituteofNeuroscience,SIBS,CAS
近期论文1.JinM,GuanCB,JiangYA,ZhaoCT,CuiK,SongYQ,WuCP,DuanSM,PooMM*,YuanXB*(2005)Ca2+-dependentregulationofRhoGTPasescantriggerturningofnervegrowthcones.J.Neuroscience,25:2338-47.
2.LiY,CuiK,JiaYC,LiN,ZhenZY,WangYZ*,YuanXB*(2005)EssentialroleofTRPCchannelsintheguidanceofnervegrowthconebyBDNF.Nature,14:835-8.
3.CuiK,YuanXB*.(2006).“TRPchannelsandaxonpathfinding”TRPIonChannelsinTransductionofSensoryStimuliandCellularSignalingCascades.Chapter4.
4.GuanCB,XuHT,JinM,YuanXB*,andPooMM*(2007)Long-RangeCa2+SignalingfromGrowthConetoSomaMediatesReversalofNeuronalMigrationInducedbySlit-2.Cell129:385-395.
5.DingS,LuoJH,andYuan,XB*(2007)Semaphorin-3FattractsthegrowthconeofcerebellargranulecellsthroughcGMPsignalingpathway.Biochem.Biophys.Res.Commun.356:857-863.
6.ChenG,SimaJ,JinM,ZhengW,WangKY,XueXJ,DingYQ,YuanXB*(2008)Semaphorin-3Aguidesradialmigrationofcorticalneuronsduringdevelopment.NatureNeurosci.,11:36-44.
7.ZhengW,YuanXB*(2008).Guidanceofcorticalradialmigrationbygradientofdiffusiblefactors.CellAdhesionandMigraiton,2:48-50(extraview).
8.ZhaoCT,LiK,LiJT,ZhengW,LiangXJ,GengAQ,LiN,andYuanXB*(2009)PKCδregulatescorticalradialmigrationbystabilizingtheCdk5activatorp35.PNAS.106:21353-21358.
