在岗研究生导师情况介绍
所系名称健康科学研究所
性别男
专业名称生物化学与分子生物学
技术职务研究员
行政职务无
Mail地址ghhu@sibs.ac.cn
指导博士
生总数1指导硕士
生总数2已毕业学生通讯地址上海市重庆南路225号
目前博士
生数1目前硕士
生数2目前在校生邮政编码200025
研究方向肿瘤转移分子机制
研究工作利用交叉学科的研究方法，结合生物信息学，分子生物学，动物模型及临床分析研究肿瘤转移的分子机制，寻找癌症预后诊断的标记和肿瘤治疗的新靶点。目前研究重点为：1)肿瘤转移动物异种移植的建立；2)肿瘤转移功能基因和分子标记物的研究；3)肿瘤转移基因的表观调控；4)乳腺癌转移的分子调控网络。
获奖情况1996清华大学新生奖
2002美国马里兰大学研究生奖
2003美国新泽西州医药与牙医大学研究成就奖
2005美国新泽西州癌症研究Gallo奖
2006美国新泽西州癌症研究委员会制博士后奖
2009美国SuanG.Komen协会博士后奖
指导研究
生情况
个人简介1996-2000清华大学生物科学与技术系，生物学士
2000-2002美国罗格斯大学生物系，生物硕士
2000-2005美国罗格斯大-UMDNJ联合培养，分子遗传学博士
2005林斯顿大学分子生物系博士后(PostdoctoralResearchAssociate)
2009美国普林斯顿大学分子生物系副研究学者(AssociateResearchScholar)
2009中国科学院上海生命科学院/上海交通大学医学院健康科学研究所组长
近期论文1.HuG,KangY.,andWangX-F.Frombreasttothebrain:unravelingthepuzzleofmetastasisorganotropism.JMolCellBiol,2009,[Epubaheadofprint]
2.WeiY,HuGandKangY.Metadherinasalinkbetweenmetastasisandchemoresistance.CellCycle,2009;8(14):2132-3.
3.HuG,WeiY,KangY.ThemultifacetedroleofMTDH/AEG-1incancerprogression.ClinicalCancerResearch,2009;15(18):5615-20.
4.LuX,WangQ,HuG,PoznakCV,FleisherM,ReissM,MassaguéJandKangY.ADAMTS1andMMP1proteolyticallyengageEGF-likegrowthfactorsinanosteolyticparacrinesignalingcascadetopromotebreastcancerbonemetastasis.Genes&Development.2009;23(16):1882-94.
5.WangHY,GreenawaltD,CuiX,TereshchenkoIV,LuoM,YangQ,AzaroMA,HuG,ChuY,LiJY,ShenL,LinY,ZhangL,LiH.IdentificationofpossiblegeneticalterationsinthebreastcancercelllineMCF-7usinghigh-densitySNPgenotypingmicroarray.JCarcinog.2009;8:6.
6.LuoM,CuiX.,FredmanD.,BrookesAJ,AzaroMA,GreenawaltDM,HuG,WangH-Y,TereshchenkoIV,ShentuY,GaoR,ShenL,LiH.Geneticstructureofduplicatedsequencesrevealedbygenotypingsinglesperm.PLoSOne.2009;4(4):e5236.
7.HuG,ChongR.,YangQ,WeiY,LiF,BlancoA,ReissM,AuJ-S,HafftyB,andKangY.MTDHactivationby8q22genomicgainpromoteschemoresistanceandmetastasisofpoor-prognosisbreastcancer.CancerCell,2009;15(1):9-20.(Coverarticle)
8.KorpalM,LeeES,HuG,andKangY.ThemiR-200familyinhibitsepithelial-mesenchymaltransitionandcancercellmigrationbydirecttargetingofE-cadherintranscriptionalrepressorsZEB1andZEB2.JBiolChem.,2008;283:14910-4.
9.YueG,ShiG,AzaroMA,YangQ,HuG,LuoM,YinK,NageleRG,FineDH,YangJandLiH.Lipopolysaccharide(LPS)potentiateshydrogenperoxidetoxicityinT98Gastrocytomacellsbysuppressionofanti-oxidativeandgrowthfactorgeneexpression.BMCGenomics,2008;9:608.
10.HuG*,YangQ*,YueG,AzaroMA,WangH-Y,CuiX,andLiH.Ahighlysensitiveandspecificsystemforlarge-scalegeneexpressionprofiling.BMCGenomics,2008;9:9.(*equalcontributors)
11.LiH,WangH-Y,CuiX,LuoM,HuG,GreenawaltDM,TereshchenkoIV,LiJY,ChuY,andGaoR.High-throughputgenotypingofsinglenucleotidepolymorphismswithhighsensitivity.MethodsMolBiol.,2007;396:281-94.
12.KangY,HuG,BlancoMA,WuH.Systemicanalysisofthemolecular,networkunderlyingbreastcancerbonemetastasis.Clinical&ExperimentalMetastasis.2007;4:222-223.
13.LuX,HuG,BlancoMA,KorpalM,LiF,TiedeB,KangY.Genesandfunctionsthatmediatebreastcancerbonemetastasis.CancerTreatmentReviews.2006;32:S27-27.
14.HuG,Wang,H-Y,FrikkerDM,AzaroMA,LuoM,TereshchenkoIV,CuiX,YangJ-M,GaoR,ShenL,andLiH.AccuTyping:Newalgorithmsforautomatedanalysisofdatafromhigh-throughputgenotypingwitholigonucleotidemicroarrays.NucleicAcidsResearch,2006;34(17):e116.
15.GreenawaltDM,CuiX,WuY,LinY,WangH-Y,LuoM,TereshchenkoIV,HuG,LiJY,ChuY.,AzaroMA,DecosteCJ,ChimgeNO,GaoR,ShenL,ShihWJ,LangeK,andLiH.Strongcorrelationbetweenmeioticcrossoversandhaplotypestructureina2.5-Mbregiononthelongarmofchromosome21.GenomeResearch,2006;16:208-214.
16.ChimgeN-O,PramanikS,HuG,andLiH.DeterminationofhaplotypeorganizationofhumanIGHVregiononsinglechromosomesbymultiplexPCRandmicroarrayanalysisofsinglesperm.GenesandImmunity,2005;6:186-193.
17.WangH-Y,LuoM,TereshchenkoIV,FrikkerDM,CuiX,LiJY,HuG,ChuY,AzaroMA,LinY,ShenL,YangQ,KambourisME,GaoR,ShihWC,andLiH.Agenotypingsystemcapableofsimultaneouslyanalyzing>1,000singlenucleotidepolymorphismsinahaploidgenome.GenomeResearch,2005;15:276-283.
18.WuQ,HuangH,HuG,ChenJ,HoKP,andChenGQ.Productionofpoly-3-hydroxybutyratebyBacillussp.JMa5cultivatedinmolassesmedia.AntonieVanLeeuwenhoek,2001;80(2):111-8.
