在岗研究生导师情况介绍
所系名称健康科学中心
性别男
专业名称神经生物学
技术职务研究员
行政职务课题组组长
Mail地址wdle@sibs.ac.cn
指导博士
生总数15指导硕士
生总数11已毕业学生通讯地址上海市瑞金二路197号科教大楼1209室
目前博士
生数6目前硕士
生数5目前在校生邮政编码200025
研究方向神经退行性疾病(帕金森病、阿尔茨海默病、肌萎缩侧索硬化症)的发病机制和靶向治疗研究
研究工作(1)帕金森病的基因突变
(2)胚胎干细胞向多巴胺能神经元发育研究
(3)Nurr1基因与多巴胺神经元发育、变性
(4)帕金森病、阿尔茨海默发病的免疫学机制
(5)低氧与阿尔茨海默病
(6)自噬在神经退行性疾病发病过程中的作用
获奖情况1987年中华药学会优秀青年药学家奖
1988年亚太药学大会优秀论文奖
1989年国家教委科学进步二等奖
1999年国际帕金森和运动障碍疾病协会大会奖
2002年国际帕金森和运动障碍疾病协会大会奖
2008年上海医学科技二等奖
2008年中华医学科技二等奖
2009年上海科技进步三等奖
指导研究
生情况指导硕士生共11人,目前在学5人;指导博士生共15人,目前在学6人。
个人简介乐卫东教授在《Proc.Natl.Acad.Sci.USA》、《NatureGenetics》、《JournalofNeuroscience》、《ProgressinNeurobiology》、《Brain》《JAMA》《CancerResearch》、《GeneTherapy》、《JournalofNeurochemistry》、《AnnalsofNeurology》、《ArchiveofNeurology》、《Neurology》、《ExperimentalNeurology》等国内外重要学术杂志上发表论文180多篇，其中SCI收集的175篇，影响因子650多分，被引用3800余次，并多次应邀参加国际学术会议做大会主席和报告。此外，乐卫东教授应邀担任了《JNeurosciences》、《Brain》、《Neurology》、《JNEN》、《HumanGenomics》、《AnnalsNeurology》、《Neuroscience》、《JournalofNeurochemistry》、《CellResearch》、《JournalofNeurogenetics》等杂志的审委，6家国际杂志的编委，NIH,VA,INSERM，法国国家研究局，新加坡科学院，国家自然科学基金等基金评审专家。
主要学历：
1978：苏州医学院医学系医学学士
1984：上海第二医科大学神经病学硕士
1987：上海第二医科大学神经病学博士
1988：美国休斯顿贝勒医学院神经病学博士后
工作经历：
1978-1980：苏州医学院第一附属医院住院医生
1983-1984：苏州医学院神经科主治医师、讲师
1987-1988：第二军医大学上海长征医院神经科主治医师、讲师
1991-1992：美国休斯顿贝勒医学院神经科助理研究员
1992-1993：美国休斯顿贝勒医学院神经科讲师
1993-1998：美国休斯顿贝勒医学院神经科助理教授
1998-2000：美国休斯顿贝勒医学院神经科高级助理教授
2000-2005：美国休斯顿贝勒医学院神经科副教授
2006-至今：美国休斯顿贝勒医学院神经科教授
2003-至今：健康科学研究所神经基因课题负责人
2009-至今：上海交通大学医学院瑞金医院，神经病学研究所共同所长
近期论文1.ChenS,ZhangXJ,SongL,LeW(2012)Autophagicdysregulationinamyotrophiclateralsclerosis.BrainPathology.22:110-116
2.PengCG,AronL,KleinR,LiM,WurstW,PrakashN,LeW(2011)Pitx3isacriticalmediatorofGDNF-inducedBDNFexpressioninnigrostriataldopaminergicneurons.JNeurosci.31(36):12802-12815.
3.TaoQQ,FanX,LiT,TangY,YangD,LeW(2011)Gendersegregationingeneexpressionandvulnerabilitytooxidativestressinducedinjuryinventralmesencephalicculturesofdopamineneurons.JNeurosci.Res.90(1):167-78
4.WangY,YangD,SongL,LiT,YangJ,ZhangX,LeWMifepristoneinduciblecaspase-1expressioninmouseembryonicstemcellseliminatestumorformationbutsparesdifferentiatedcellsinvitroandinvivo.StemCells.Epubaheadofprint.
5.HengX,BreerH,ZhangX,TangY,LiJ,ZhangS,LeW(2011)Sall3CorrelateswiththeExpressionofTHinMouseOlfactoryBulb.MolNeurosci.[Epubaheadofprint]
6.YangDH,LiT,WangY,YangJ,CuiHJ,TangY,ZhangXJ,ChenDG,ShenN,LeW(2011)miR-132regulatesthedifferentiationofdopamineneuronsbydirectlytargetingNurr1expression.JournalofCellScience.[Epubaheadofprint]
7.WangQ,ZhangXJ,ChenS,ZhangX,ZhangS,YoudiumM,LeW(2011)PreventionofMotorNeuronDegenerationbyNovelIronChelatorsinSOD1G93ATransgenicMiceofAmyotrophicLateralSclerosis.NeurodegenerDis.8(5):310-321.
8.ZhangX,HengX,LiT,LiL,YangD,ZhangXJ,DuY,DoodyRS,LeW(2011)Long-TermTreatmentwithLithiumAlleviatesMemoryDeficitsandReducesAmyloid-βProductioninanAgedAlzheimer’sDiseaseTransgenicMouseModel.JAlzheimersDis.24(4):739-749.
9.ZhangXJ,LiL,ChenS,YangD,WangY,ZhangX,WangZ,LeW(2011)RapamycintreatmentaugmentsmotorneurondegenerationinSOD1(G93A)mousemodelofamyotrophiclateralsclerosis.Autophany.7(4):412-425.
10.WangZ,YangD,ZhangX,LiT,LiJ,TangY,LeW(2011)Hypoxia-induceddown-regulationofneprilysinbyhistonemodificationinmouseprimarycorticalandhippocampalneurons.Plosone.29;6(4):e19229.
11.MingM,MingM,ManziniI,LeW,KrieglsteinK,SpittauB(2010)Thapsigargin-inducedCa(2+)increaseinhibitsTGFbeta1-mediatedSmad2transcriptionalresponsesviaCa(2+)/calmodulin-dependentproteinkinaseII.JCellBiochem.111(5):1222-1230.
12.HengXandLeW**.(2010)ThefunctionofDNAtopoisomeraseIIβinneuronaldevelopment.NeurosciBull.26(5):411-6.
13.LiL,ZhangXJ,LeW(2009)AutophagydysfunctioninAlzheimer’sdisease.NeurodegenerDis.7(4):265-71.
14.ZhangXJ,ChenS,LiL,WangQ,LeW(2010)Decreasedlevelof5-methyltetrahydrofolate:apotentialbiomarkerforpre-symptomaticamyotrophiclateralsclerosis.JNeurolSci.293(1-2):102-5.
15.LuoGR,LeW(2010)Collectiverolesofmolecularchaperonesinproteindegradationpathwaysassociatedwithneurodegenerativediseases.CurrPharmBiotechnol.11(2):180-7.
16.FanXL,LuoGR,YangDH,MingM,LiuHM,PuP,LeW(2010)CriticalroleoflysosomeanditsassociatedproteincathepsinDinmanganese-inducedtoxicityinculturedmidbrainastrocyte.NeurochemistryInternational.56(2):291-300.
17.ZhangX,LeW(2010)PathologicalroleofhypoxiainAlzheimer’sdisease.ExpNeurol.223(2):299-303.
18.LiJ,DaniJA,LeW(2009)TheroleoftranscriptionfactorPitx3indopamineneurondevelopmentandParkinson’sdisease.CurrTopMedChem.9(10):855-9.
19.MingM,LiX,FanX,YangD,LiL,ChenS,GuQ,LeW(2009)Retinalpigmentepithelialcellssecreteneurotrophicfactorsandsynthesizedopamine:possiblecontributiontotherapeuticeffectsofRPEcelltransplantationinParkinson’sdisease.JTranslMed.7:53-62.
20.LiL,ZhangX,YangD,LuoG,ChenS,LeW(2009)HypoxiaincreasesAbetagenerationbyalteringbeta-andgamma-cleavageofAPP.NeurobiolAging.30:1091-1098.
21.DuY,YangD,LiL,LuoG,LiT,FanX,WangQ,ZhangX,WangY,LeW(2009)Aninsightintothemechanisticroleofp53-mediatedautophagyinductioninresponsetoproteasomalinhibition-inducedneurotoxicity.Autophagy.5:1-13.
22.FanXL,LuoGR,MingM,PuP,LiL,YangDH,LeW(2009)Nurr1expressionanditsmodulationinmicroglia.Neuroimmunomodulation.16:162-70.
23.LeW,ChenS.(2009)BiologyofNR4Asubfamily.TheEncyclopediaofMovementDisorders.495:1-4.
24.PuPandLeW(2008)DopamineneurondegenerationinducedbyMPP+isindependentofCED-4pathwayinCaenorhabditiselegans.CellRes.18(9):978-81.
25.YangDH,PengCG,LiL,FanXL,LeW(2008)Pitx3-transfectedastrocytessecretebrain-derivedneurotrophicfactorandglialcellline-derivedneurotrophicfactorandprotectdopamineneuronsinmesencephaloncultures.JNeurosciRes.86:3393-3400.
26.LuoGR,ChenY,LiXP,LiuTX,LeW(2008)Nr4a2isessentialforthedifferentiationofdopaminergicneuronsduringzebrafishembryogenesis.MolCellNeurosci.9:202-210.
27.LiXP,DuYL,FanXL,YangDH,LuoGR,LeW(2008)c-JunN-TerminalKinaseMediatesLactacystin-InducedDopamineNeuronDegeneration.JNeuropatholExpNeurol.67:933-944.
28.ChenS,ZhangXJ,YangD,DuY,LiL,LiX,MingM,LeW(2008)D2/D3receptoragonistropiniroleprotectsdopaminergiccelllineagainstrotenone-inducedapoptosisthroughinhibitionofcaspase-andJNK-dependentpathways.FEBSLetters.582:603-610.
29.ZhangXJ,ChenS,LiL,WangQ,LeW(2008)Folicacidprotectsmotorneuronsagainsttheincreasedhomocysteine,inflammationandapoptosisinSOD1G93Atransgenicmice.Neuropharmacology.54:1112-1119.
30.Pérez-BelloD,XuZH,Higginson-ClarkeD,RojasAM,LeW,Rodríguez-TantyC(2008).DNA-labelledcytidineassayforthequantificationofCAGrepeats.JNeurosciMethods.30;169(1):201-7.
31.WangYM,PuP,LeW(2007)ATPdepletionisthemajorcauseofMPP+induceddopamineneuronaldeathandwormlethalityinalpha-synucleintransgenicC.elegans.NeurosciBull.23(6):329-35.
32.WangY,ChenS,YangD,LeW(2007)Stemcelltransplantation:apromisingtherapyforParkinson’sdisease.JNeuroimmunePharmacol.2(3):243-50.
33.SunB,ChenS,ZhanS,LeW,KrahlSE(2007)Subthalamicnucleusstimulationforprimarydystoniaandtardivedystonia.ActaNeurochirSuppl.97(Pt2):207-14.
34.ChenS,ZhangXJ,LiL,LeW(2007)CurrentexperimentaltherapyforAlzheimer’sdisease.CurrNeuropharmacol.5(2):127-34.
35.DuY,LiX,YangD,ZhangX,ChenS,HuangK,LeW(2008)MultiplemolecularpathwaysareinvolvedintheneuroprotectionofGDNFagainstproteasomeinhibitorinduceddopamineneurondegenerationinvivo.ExpBiolMed(Maywood).233(7):881-90.
36.PuP,LeW(2006).C.elegansasamodelsystemforParkinsondisease.NeurosciBull.22(2):124-128.
37.LiX,YangD,LiL,PengC,ChenS,LeW(2007)Proteasomeinhibitorlactacystindisturbstheintracellularcalciumhomeostasisofdopamineneuronsinventralmesencephaliccultures.NeurochemInt.50(7-8):959-65.
38.MingM,LeW(2007)Retinalpigmentepithelialcells:biologicalpropertyandapplicationinParkinson’sdisease.ChinMedJ(Engl).120(5):416-20.
39.XuZ,ChenS,LiX,LuoG,LiL,LeW(2006)Neuroprotectiveeffectsof(-)-epigallocatechin-3-gallateinatransgenicmousemodelofamyotrophiclateralsclerosis.NeurochemRes.31(10):1263-9.
40.LiR,PengN,LiXP,LeW(2006)(-)-EpigallocatechingallateregulatesdopaminetransporterinternalizationviaproteinkinaseC-dependentpathway.BrainRes.1097(1):85-9.
41.LiX,PengC,LiL,MingM,YangD,LeW(2007)Glialcell-derivedneurotrophicfactorprotectsagainstproteasomeinhibition-induceddopamineneurondegenerationbysuppressionofendoplasmicreticulumstressandcaspase-3activation.JGerontolABiolSciMedSci.62(9):943-50.
42.PengC,FanS,LiX,FanX,MingM,SunZ,LeW(2007)Overexpressionofpitx3upregulatesexpressionofBDNFandGDNFinSH-SY5Ycellsandprimaryventralmesencephaliccultures.FEBSLett.581(7):1357-61.
43.LuoGR,ChenS,LeW(2006)AreheatshockproteinstherapeutictargetforParkinson’sdisease?IntJBiolSci.3(1):20-6.
44.ChenS,LeW(2006)NeuroprotectivetherapyinParkinsondisease.AmJTher.13(5):445-57.
45.LiXP,LeW(2006)Applicationofsinglecellgeneexpressionanalysistechniquesonneurosciencesresearch.ShengLiKeXueJinZhan.37(1):55-7.
46.LiR,PengN,DuF,LiXP,LeW(2006)Epigallocatechingallateprotectsdopaminergicneuronsagainst1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-inducedneurotoxicitybyinhibitingmicroglialcellactivation.NanFangYiKeDaXueXueBao.26(4):376-80.
47.DuF,LiR,HuangY,LiX,LeW(2005)DopamineD3receptor-preferringagonistsinduceneurotrophiceffectsonmesencephalicdopamineneurons.EurJNeurosci.22(10):2422-30.
48.JankovicJ,ChenS,LeW(2005)TheroleofNurr1inthedevelopmentofdopaminergicneuronsandParkinson’sdisease.ProgNeurobiol.77(1-2):128-38.
49.LiuX,FanXL,ZhaoY,LuoGR,LiXP,LiR,LeW(2005)Estrogenprovidesneuroprotectionagainstactivatedmicroglia-induceddopaminergicneuronalinjurythroughbothestrogenreceptor-alphaandestrogenreceptor-betainmicroglia.JNeurosciRes.81(5):653-65.
50.LiR,HuangYG,FangD,LeW(2004)EGCGinhibitsLPS-inducedmicroglialactivationandprotectsagainstinflammation-mediateddopaminergicneuronalinjury.JNeurosciRes.78(5):723-31.
