在岗研究生导师情况介绍
所系名称营养科学研究所
性别男
专业名称生物化学与分子生物学
技术职务研究员
行政职务常务副所长
Mail地址ychen3@sibs.ac.cn
指导博士
生总数4指导硕士
生总数0已毕业学生通讯地址上海太原路294号
目前博士
生数4目前硕士
生数0目前在校生邮政编码200031
研究方向细胞信号传导，基因调控，免疫调节，肿瘤发生机理
研究工作 运用分子生物学、细胞生物学和动物模型研究TGF-beta和营养相关疾病的细胞信号传导、基因调控、肿瘤发生机理和动物早期发育机制。
获奖情况1988通过全国中美生物联合培养CUSBEA项目
1996美国肿瘤协会（AmericanCancerSociety）博士后基金
1999美国内分泌协会travel基金
1999美国心脏协会（AmericanHeartAssociation）科学家发展基金
2005国家基金委杰出青年
2006上海市优秀学科带头人
2006明治乳业科学奖
2006入选“新世纪百千万人才工程”国家级人选
2007获国务院政府特殊津贴
指导研究
生情况 目前指导博士生10人
个人简介1983年华西医科大学医学系，学士
1986年华西医科大学儿科系，硕士
1986年－1987年华西医科大学附属医院儿科，住院医师
1987年－1989年华西医科大学医学分子生物学研究所，助教
1994年美国Indiana大学医学和分子遗传系，博士
1994年－1996年美国加利福尼亚大学圣地亚哥分校(UCSD)，博士后
1996年－1998年美国Salk研究所，博士后
1998年－2004年美国印第安纳大学医学和分子遗传系，助理教授，副教授
2004年－中国科学院上海生命科学研究院营养科学研究所，研究员
近期论文代表性论文（共有60余篇SCI论文发表）:
1.Chen,Y.,Mestek,A.,Liu,J.,Hurley,J.A.andYu,L.(1993)Molecularcloningandfunctionalexpressionofamuopioidreceptorfromratbrain.MolecularPharmacology44,8-12.(AcceleratedCommunication)
2.Chen,Y.,Mestek,A.,Liu,J.andYu,L.(1993)Molecularcloningofaratkappaopioidreceptorrevealssequencesimilaritiestothemuanddeltaopioidreceptors.BiochemicalJournal295,625-628
3.Chen,Y.,Fan,Y.,Liu,J.,Mestek,A.,Tian,M.,Kozak,C.A.andYu,L.(1994)Molecularcloning,tissuedistributionandchromosomallocalizationofanovelmemberoftheopioidreceptorgenefamily.FEBSletter347,279-283
4.Chen,Y.andYu,L.(1994)DifferentialregulationbycAMP-dependentproteinkinaseandproteinkinaseCofthemuopioidreceptorcouplingtoaGprotein-activatedpotassiumchannel.JournalofBiologicalChemistry269,7839-7842.(Communication)
5.Chen,Y.,Baez,M.andYu,L.(1994)Functionalcouplingofthe5-HT2CserotoninreceptortoGproteinsinXenopusoocytes.NeuroscienceLetter179,100-102
6.Mestek,A.,Hurley,J.H.,Bye,L.S.,Campbell,A.D.,Chen,Y.,Tian,M.,Liu,J.,Schulman,H.andYu,L.(1995)Thehumanmuopioidreceptor:molecularcloning,pharmacologicalcharacterization,andmodulationofintracellularsignalingbyproteinkinase.JournalofNeuroscience15,2396-406
7.Chen,Y.,Liu,J.andYu,L.(1996)FunctionalcouplingofamuopioidreceptortoGproteinsandadenylylcyclase:modulationbychronicmorphinetreatment.AddictionBiology1,49-59
8.Chen,Y.,Knudsen,E.S.andWang,J.Y.J.(1996)CellsarrestedinG(1)byv-AbltyrosinekinasedonotexpresscyclinAdespitethehyperphosphorylationofRB.JournalofBiologicalChemistry271,19637-19640(Communication)
9.Liu,Z.,Baskaran,R.,Lea-Chou,E.T.,Wood,L.D.,Chen,Y.,Karin,M.andWang,J.Y.J.(1996)Threedistinctsignalingresponsesbymurinefibroblaststogenotoxicstress.Nature384,273-276
10.Chen,Y.,Knudsen,E.S.andWang,J.Y.J.(1996)TheRB/P107/P130phosphorylationpathwayisnotthetargetofinhibitioninrapamycin-induceddelayofG1/Stransition.Oncogene13,1765-1771
11.Chen,Y.,Lebrun,J.J.andVale,W.(1996)Regulationoftransforminggrowthfactorbeta-andactivin-inducedtranscriptionbymammalianMadproteins.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica93,12992-12997
12.Chen,Y.,Bhushan,A.andVale,W.(1997)Smad8mediatesthesignalingoftheALK-2receptorserinekinase.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica94,12938-12943
13.Bhushan,A.,Chen,Y.andVale,W.(1998)Smad7inhibitsmesodermformationandpromotesneuralcellfateinXenopusembryos.DevelopmentalBiology200,260-268
14.Lebrun,J.J.,Takabe,K.,Chen,Y.andVale,W.(1999)Rolesofpathway-specificandinhibitorySmadsinactivinreceptorsignaling.MolecularEndocrinology13,15-23
15.Nagarajan,R.P.,Liu,J.andChen,Y.(1999)Smad3inhibitstransforminggrowthfactor-betaandactivinsignalingbycompetingwithSmad4forFAST-2binding.JournalofBiologicalChemistry274,31229-31235（为通讯作者）
16.Nagarajan,R.P.,Zhang,J.,Li,W.andChen,Y.(1999)RegulationofSmad7promoterbydirectassociationwithSmad3andSmad4.JournalofBiologicalChemistry274,33412-33418.（为通讯作者）
17.Nagarajan,R.P.,ChenF.,LiW.,Vig,E.,Harrington,M.A.,Nakshatri,H.andChen,Y.(2000)Repressionoftransforminggrowthfactor-beta-mediatedtranscriptionbyNuclearFactor-kappaB.BiochemicalJournal348,591-196.（为通讯作者）
18.Nagarajan,R.P.andChen,Y.(2000)StructuralbasisforthefunctionaldifferencebetweenSmad2andSmad3inFAST-2(forkheadactivinsignaltransducer-2)-mediatedtranscription.BiochemicalJournal350,253-259.（为通讯作者）
19.Chen,F.,Ogawa,K.,Liu,X.,Stringfield,T.M.andChen,Y.(2002)RepressionofSmad2andSmad3transactivationbyassociationwithanovelsplicevariantofCCAATbindingfactorCsubunit.BiochemicalJournal364,571-7.（为通讯作者）
20.Liu,X.,Nagarajan,R.P.,Vale,W.andChen,Y.(2002)PhosphorylationregulationoftheinteractionbetweenSmad7andactivintypeIreceptor.FebsLetter519,93-8.（为通讯作者）
21.Chen,F.,Ogawa,K.,Nagarajan,R.P.,Zhang,M.,Kuang,C.andChen,Y.(2003)RegulationofTG-interactingFactorbyTransformingGrowthFactor-beta.BiochemicalJournal371,257-63（为通讯作者）
22.Ogawa,K.,Chen,F.,Kim,Y.J.andChen.Y.(2003)TranscriptionalregulationoftristetraprolinbyTransformingGrowthFactor-betainhumanTcells.JournalofBiologicalChemistry278,30373-81（为通讯作者）
23.Kuang,C.andChen,Y.(2004)Tumor-derivedC-terminalmutationsofSmad4withdecreasedDNAbindingactivityandenhancedintramolecularinteraction.Oncogene23:1021-9（为通讯作者）
24.Ogawa,K.,Chen,F.,Kuang,C.andChen.Y.(2004)Suppressionofmatrixmetalloproteinase-9transcriptionbytransforminggrowthfactor-betaismediatedbyaNF-kappaBsite.BiochemicalJournal381,413-22（为通讯作者）
25.Shi,H.,Hudson,L.G.,Ding,W.,Wang,S.,Cooper,K.L.,Liu,S.,Chen,Y.,Shi,X.andLiu,K.J.(2004)ArsenitecausesDNAdamageinkeratinocytesviagenerationofhydroxylradicals.ChemicalResearchandToxicology.17,871-878
26.Kim,Y.,Stingfield,T.,Chen,Y.andBroxmeyer,H.E.(2005)ModulationofcordbloodCD8+celleffectordifferentiationbyTGF-beta1and4-1BBcostimulation.Blood105,274-81.
27.Qian,Y.,Liu,K.J.,Chen,Y.,Flynn,D.C.,Castranova,V.andShi,X.(2005)Cdc42regulatesarsenic-inducedNADPHoxidaseactivationandcellmigrationthroughactinfilamentreorganization.JournalofBiologicalChemistry280,3875-84
28.Lin,L.,Qian,Y.,Shi,XandChen,Y.(2005)InductionofacellstressresponsegeneRTP801byDNAdamagingagentmethylmethanesulfonatethroughCCAAT/EnhancerBindingProtein.Biochemistry44:3909-14（为通讯作者）
29.Jin,L.,Zhou,Y.,Kuang,C,Lin,LandChen,Y.(2005)ExpressionpatternofTG-interactingfactor2duringmousedevelopment.GeneExpressionPatterns(MechanismofDevelopment)5,457-62.（为通讯作者）
30.Suszko,M.I.,Balkin,D.M.,Chen,Y.andWoodruff,T.K.(2005)Smad3mediatesactivin-inducedtranscriptionoffollicle-stimulatinghormonebeta-subunitgene.MolecularEndocrinology19,1849-58.
31.Zhou,Y.,Sun,X,Jin,L,Stringfield,T,Lin,LandChen,Y.(2005)Expressionprofilesofadiponectinreceptorsinmouseembryos.GeneExpressionPatterns(MechanismofDevelopment)5,711-5（为通讯作者）
32.Lin,L.,Stringfield,T.,Shi,X.andChen,Y.(2005)ArseniteinducesacellstressresponsegeneRTP801throughreactiveoxygenspeciesandtranscriptionfactorsElk-1andCCAAT/enhancerbindingprotein.BiochemicalJournal392,93-102（为通讯作者）
33.Kuang,C.,Xiao,Y.,Liu,X.,Stringfield,T.M.,Zhang,S.,Wang,Z.andChen,Y.(2006)Invivodisruptionoftransforminggrowthfactor-signalingbySmad7leadstopremalignantductallesionsinthepancreas.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica103,1858-63（为通讯作者）
34.Sun,X.,Han,R.,Wang,Z.andChen.Y.(2006)Regulationofadiponectinreceptorsbyperoxisomeproliferator-activatedreceptor-gammaagonistrosiglitazoneinhepatocytes.Diabetologia49,1303-10.（为通讯作者）
35.Chou,Y.T.,Wang,H.,Chen,Y.,Danielpour,D.,Yang,Y.C.(2006)Cited2modulatesTGF-beta-mediatedupregulationofMMP9.Oncogene25,5547-60.
36.Ogawa,K.,Funaba,M.,Chen,Y.andTsujimoto,M.(2006)ActivinAfunctionsasaTh2cytokineinthepromotionofthealternativeactivationofmacrophages.JournalofImmunology177,6787-94.
37.Kuang,C.,Xiao,Y.,Yang,L.,Chen,Q.,Wang,Z.,Conway,SJ.,andChen,Y.(2006)IntragenicDeletionofTgifCausesDefectsinBrainDevelopment.HumanMolecularGenetics15,3508–19（为通讯作者）
38.Liu,X.,Chen,Q.,Kuang,C.,Zhang,M.,Ruan,Y.,Xu,Z.C.,Wang,Z.,Chen,Y.(2007)A4.3kbSmad7promoterisabletospecifygeneexpressionduringmousedevelopment.BiochimicaetBiophysicaActa1769,149-52（为通讯作者）
39.Xie,X.,Wang,Z.,andChen,Y.(2007)AssociationofLKB1withaWD-repeatproteinWDR6isimplicatedincellgrowtharrestandp27(Kip1)induction.MolecularandCellularBiochemistry301:115-22（为通讯作者）
40.Ding,Q.,Jin,T.,Wang,Z.andChen,Y.(2007)Catalasepotentiatesretinoicacid-inducedTHP-1monocytedifferentiationintomacrophagethroughinhibitionofperoxisomeproliferator-activatedreceptorgamma.JournalofLeukocyteBiology.81:1568-76（为通讯作者）
41.Han,R.,Lai,R.,Ding,Q.,Wang,Z.,Luo,X.,Zhang,Y.,Cui,G.,He,J.,Liu,W.andChen,Y.(2007)ApolipoproteinA-IstimulatesAMP-activatedproteinkinaseandimprovesglucosemetabolism.Diabetologia.50:1960-8（为通讯作者）
42.Feng,L.,Xie,X.,Ding,Q.,Luo,X.,He,J.,Fan,F.,Liu,W.,Wang,Z.andChen,Y.(2007)SpatialregulationofRafkinasesignalingbyRKTG.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica104,14348-53（为通讯作者）
43.Yang,L.,Wu,Y.,Li,H.,Yu,Z.,Li,X.,Liu,Y.,Lin,X.,andChen,Y.(2008)PotentialassociationofINSIG2rs7566605polymorphismwithbodyweightinaChinesesubpopulation.EuropeanJournalofHumanGenetics(2008)15，759-61（为通讯作者）
44.Fan,F.,Feng,L.,He,J.,Wang,X.,Jiang,X.,Zhang,Y.,Wang,Z.andChen,Y.(2008).RKTGsequestersB-RaftotheGolgiapparatusandinhibitstheproliferationandtumorigenicityofhumanmalignantmelanomacells.Carcinogenesis.May29.[Epubaheadofprint]（为通讯作者）
45.Luo,X.,Feng,L.,Jiang,X.,Xiao,F.,Wang,Z,Feng,G.S.andChen,Y.(2008)CharacterizationofthetopologyandfunctionaldomainsofRKTG.BiochemicalJournal(Accepted)（为通讯作者）
46.Xie,X.,Zhang,Y.,Jiang,Y.,Liu,W.,Ma,H.,Wang,Z.andChen,Y.(2008)SuppressivefunctionofRKTGonchemicalcarcinogen-inducedskincarcinogenesisinmouse.Carcinogenesis(Accepted)（为通讯作者）
