在岗研究生导师情况介绍
所系名称计算生物学研究所
性别女
专业名称计算生物学
技术职务研究员
行政职务无
Mail地址christine@picb.ac.cn
指导博士
生总数0指导硕士
生总数0已毕业学生通讯地址上海市岳阳路320号计算生物学研究所
目前博士
生数0目前硕士
生数2目前在校生邮政编码200031
研究方向临床基因网络
研究工作Thanktotheinnovativeapproachestogenetic(genomics),medicineisfacingthetangiblepossibilitytoshiftitsconventionalapproachtowardpersonalizedmedicine.Thisisanevidencebasedscience,abletoimprovedramaticallytheefficiencyofpreventionandtreatmentsbyreducingsideeffectsandempoweringtherapeuticapproaches.Thisscienceisrootedintheconceptofgenomicprofile,thatistheensemblenotonlyofspecificgenesvariants(genotype),butalsoofspecificpatternsof(disrupted)genes'activation,typicalofeachuniquepatient-and-diseasecomplex.Knowingthegenomicprofileofanindividualinagivenconditionmightallowtodefineabettertargetedtherapeuticapproach.
However,theidentificationofdisruptedpatternsinagenomicprofileisextremelycomplex,anddifferentapproachesaswellasdifferentsamplesunderstudycanhighlightdifferentandsometimesnon-overlappingsetsofgenesresponsibleforthecomplexchangesthatareundergoinginacellduringadisease.Thus,thetranslationoftheseconceptsintomedicalpracticerepresentsstillandimportantchallenge.
Ourresearchfocusesontheidentificationofapproachesthattrytoresolvesuchapparentincongruities,notablyusinggenenetworkreverseengineeringapproachesandsystemicapproaches,instrongconnectionwiththeuseofexperimentaldata.
Theobjectiveistwo-fold:
*identifyapproachesthatcanusediversegenesignaturesasasourceofinformationenrichmenttobuildmorecomplex,multidimensional(networksvslists)genesignatures
*usetheseapproachestogetinsightintothefunctioningofinnovative/alternativemedicalapproaches
获奖情况
指导研究
生情况
个人简介Universityqualification
•2003-2005-PhDinElectronicsandInformaticsatUniversityofBologna.Supervisor:Prof.LucaBenini.
•2003-2004–VisitingresearcherattheComputerScienceDepartmentatStanfordUniversity(CA,USA),withProfGiovannideMicheli.Forthedevelopmentofdataminingalgorithmstobeappliedtomicroarraysforgeneexpressionanalyses.
•1999NationalHabilitationtoEngineersProfessionalActivity.
•1992-1998–MasterDegreeinElectricalEngineering–BiomedicalspecializationattheUniversityofBologna(90/100).Tutor:Prof.MauroUrsino
•1992–BSDegreeatIstitutoN.CopernicoinBologna(60/60).
Employmentrecord
since02/2008ResearchgroupleaderoftheClinicalGenomicNetworkgroup,inajointappointmentoftheMax-Planck-SocietyandtheChineseAcademyofSciences,atthePICB,Shanghai.
2007.CollaboratorattheTelethonInstituteforGeneticsandMedicine(Naples,Italy)withtheSystemsBiologyLab
2006-2007.ResearchAssistantattheDepartmentofElectronicInformaticsandSystems(DEIS)attheUniversityofBologna(Italy).
2006-2008.Professorforthemoduleofsystemsbiology-biosensorsattheInternationalMasterofBioinformatics,UniversityofBologna,Italy.
1999-2002.FieldEngineerintheCardiacRhythmManagementDivisionatMedtronicS.p.A.forassistanceduringimplantandfollow-upofpatientswithimplantabledevicesforbrady/tachyarrhythmias.Educationactivityonbrady/tachyarrhythmiasandcardiacstimulationfornursesandmedicaldoctorsinvarioushospitalsintheregionsofEmiliaRomagnaandMarche.
Teachingexperience
SystemsbiologymoduleinthecourseBiosensorsattheInternationalMasterofBioinformatics,UniversityofBologna,Italy
近期论文Publishedandacceptedpapers(allpeerreviewed)
•C.Guiducci,C.Nardini,HighParallelism,PortabilityandBroadAccessibility:TechnologiesforGenomics,ACMJournalonEmergingTechnologiesinComputingSystems,2008,inpress
•C.Nardini,M.D.KuoandL.Benini,StatisticalSignificanceinomicdataanalyses,ProceedingsofInternationalConferenceonbio-inspiredsystemsandsignalprocessingBiosignals2008,Portugal,inpress.
•D.Masotti,C.Nardini,S.Rossi,E.Bonora,G.Romeo,S.VoliniaandL.Benini,TOM:enhancementandextensionofatoolsuiteforinsilicoapproachestomultigeniccomplexdisorders,Bioinformatics,2007,doi:10.1093/bioinformatics/btm588.
•C.Nardini,L.BeniniandG.deMicheli,CircuitsandSystemsforHigh-ThroughputBiology,IEEECircuitsandSystemsMagazine,2006,6(3),pp.10-20.
•C.Nardini,D.Masotti,S.Yoon,E.Macii,M.D.Kuo,G.deMicheliandL.Benini,Mininggenesetsformeasuringsimilarities,ProceedingsofIEEESymposiumonComputersandCommunications(ISCC),2006.
•M.Diehn,C.Nardini,D.S.Wang,A.Hsiao,S.ChaandM.D.KuoNeuroimagingCharacteristicsReflectTumorGeneExpressionSignaturesandPredictSurvivalinGlioblastomaMultiforme,InternationalJournalofRadiationOncologyBiologyPhysics,Volume66,Issue3,Supplement1,2006,PageS18
•S.Rossi-D.Masotti,C.Nardini,E.Bonora,G.Romeo,E.Macii,L.BeniniandS.Volinia,TOM:aweb-basedintegratedapproachforefficientidentificationofcandidatediseasegenes,NucleicAcidsRes.,34:W285-W292;doi:10.1093/nar/gkl340.
•S.Yoon,C.Nardini,L.BeniniandG.deMicheli,DiscoveringcoherentbiclustersfromgeneExpressionDataUsingZero-SuppressedBinaryDecisionDiagrams,TheIEEE/ACMTransactiononComputationalBiologyandBioinformatics,Vol.3,N.2,2005.
•S.Yoon,C.Nardini,L.BeniniandG.deMicheli.EnhancedpClusteringanditsapplicationstogeneexpressiondata,InProceedingsofIEEESymposiumonBIBE(BioinformaticsandBioengineering),pp.275-282,2004.
