在岗研究生导师情况介绍
所系名称计算生物学研究所
性别男
专业名称计算生物学
技术职务研究员
行政职务课题组长
Mail地址lijin.picb@gmail.com
指导博士
生总数35指导硕士
生总数8已毕业学生通讯地址上海市岳阳路320号计算生物学研究所
目前博士
生数6目前硕士
生数2目前在校生邮政编码200031
研究方向计算基因组学
研究工作1.群体遗传结构研究(Developingapproachesforexploringthegeneticstructureofpopulations)
2.人类复杂遗传疾病研究(Mappinggenesthatunderlyhumandiseaseswithcomplexcauses)
3.生物网络重组研究(Reconstructingbiologicalnetworksincludingsignaltransduction)
4.新陈代谢通道及控制模型研究(Metabolicpathways,andmodelingthecontrolsofsuchnetworks)
目前承担及参与主要项目共3项，其中：国家级2项，部（省）级1项
中华民族基因组结构与功能研究863项目2002－2005参与
环境化学污染物致机体损伤及其防御的基础研究973项目2002－2007主持
心血管等重大疾病相关的生物系统网络
结构及其动力学研究上海市科委重大项目2004－2007主持
获奖情况
1998杰出青年基金B类教育部
1998科技进步二等奖教育部
1998-2001优秀研究奖德克萨斯大学公共卫生学院
1999-2001优秀学者奖德克萨斯大学公共卫生学院
2000院长奖德克萨斯大学-休斯顿健康科学中心
2000教育部特聘长江讲座教授教育部
2003科技进步一等奖教育部
2004校长奖复旦大学
2005科技进步一等奖上海市
指导研究
生情况近五年来（含已毕业和在培）
复旦大学遗传所及现代人类学中心研究生35名博士后5名
个人简介81–88复旦大学遗传学专业本科生、硕士生、博士生
88–90德克萨斯大学休斯顿健康科学中心人口统计及群体遗传学中心工作人员助理
90–94德克萨斯大学休斯顿健康科学中心研究生院博士研究生（生物医学/遗传学）
94–96斯坦福大学医学院遗传学系博士后
97–00德克萨斯大学休斯顿公共卫生学院人类遗传中心助理教授
97–01德克萨斯大学休斯顿生物医学研究生院助理教授、副教授
97–复旦大学遗传所人类群体遗传学及复杂疾病实验室兼职教授
99–04中国人类基因多样性委员会秘书
00–01德克萨斯大学休斯顿公共卫生学院人类基因中心副教授（终身教职）
01–05辛辛那提大学医学院环境卫生系基因组信息中心教授（终身教职）
01–05辛辛那提大学医学院基因型分型平台主任
02–05辛辛那提大学医学院功能基因组及基因芯片平台主任
02–复旦大学现代人类学研究中心主任
02–中国社会科学院中国古文明研究中心客座研究员
03–复旦大学生命科学学院院长
07-复旦大学副校长
05–中科院-马普学会计算生物学伙伴研究所所长
近期论文SelectedPublications:
ShuhuaXu,DaoroongKangwanpong,MarkSeielstad,MetaweeSrikummool,JatupolKampuansai,LiJin,TheHUGOPan-AsianSNPConsortium.GeneticevidencesupportslinguisticaffinityofMlabri-ahunter-gatherergroupinThailand.BMCGenetics,11:18
YungangHe,ShuhuaXu,ChuanJia,LiJin2009.Adesignofmulti-sourcesamplesasasharedcontrolforassociationstudiesingeneticallystratifiedpopulations.CellResearch19:913-915,
ZhijunWang,LiJin,ZhenghongYuan,GrzegorzWegrzynandAlicjaWegrzyn.ClassificationofPlasmidVectorsUsingReplicationOrigin,SelectionMarkerandPromoterasCriteria.Plasmid,,2009,61(1):47-51
ZhijunWang,LiJin,GrzegorzWegrzynandAlicjaWegrzyn.ANovelMethodforScreeningtheGlutathioneTransferaseInhibitors.BMCBiochemistry,,2009,10:6
RongLin,YingWang,YiWang,WenqingFu,DandanZhang,HongxiangZheng,TingYu,YingWang,MinShen,RongLei,HongWu,AijunSun,RuifangZhang,XiaofengWang,MomiaoXiong,WeiHuangandLiJin.CommonVariantsofFourBilirubinMetabolismGenesandTheirAssociationwithSerumBilirubinandCoronaryArteryDiseaseinChineseHanPopulation.PharmacogeneticsandGenomics,,2009,19(4):310-318
YungangHe,ShuhuaXu,ChuanJiaandLiJin.ADesignofMulti-sourceSamplesasaSharedControlforAssociationStudiesinGeneticallyStratifiedPopulations.CellResearch,,19(7):913-915
ShuhuaXu,WenfeiJinandLiJin.HaplotypeSharingAnalysisShowingUyghursAreUnlikelyGeneticDonors.MolecularBiologyandEvolution,,2009,26(10):2197-2206
FuzhongXue,YiWang,ShuhuaXu,FengZhang,BoWen,XuesenWu,MingLu,RanjanDeka,JiQianandLiJin.ASpatialAnalysisofGeneticStructureofHumanPopulationsinChinaRevealsDistinctDifferencebetweenMaternalandPaternalLineages.EuropeanJournalofHumanGenetics,,2008,16:705-717
ShuhuaXu,WeiHuang,JiQianandLiJin.AnalysisofGenomicAdmixtureinUyghurandItsImplicationinMappingStrategy.TheAmericanJournalofHumanGenetics,,2008,82:883-894
ShuhuaXuandLiJin.AGenome-wideAnalysisofAdmixtureinUyghursandaHigh-DensityAdmixtureMapforDisease-GeneDiscovery.TheAmericanJournalofHumanGenetics,,2008,83(3):322-336
ZhijunWang,ZhenghongYuanandLiJin.GeneDeliveryintoHepatocyteswiththepreS/liposome/DNASystem.BiotechnologyJournal,,2008,3(9-10):1286-1295
DandanZhang,ChunhongShao,MinhuaShao,PengrongYan,YiWang,YixiaoLiu,WenhongLiu,TongLin,YuyingXie,YingnanZhao,DaruLu,YifengLiandLiJin.Effectofµ-OpioidReceptorGenePolymorphismonHeroin-InducedSubjectiveResponsesinaChinesePopulation.BiologicalPsychiatry,,2007,61(11):1244-1251
ShuhuaXu,WeiHuang,HaifengWang,YungangHe,YingWang,YiWang,JiQian,MomiaoXiongandLiJin.DissectingLinkageDisequilibriuminAfrican-AmericanGenomes:RolesofMarkersandIndividuals.MolecularBiologyandEvolution,,2007,24(9):2049-2058
KellyFrazer,DennisBallinger,DavidCox,etal.ASecondGenerationHumanHaplotypeMapofOver3.1MillionSNPs.Nature,,2007,449:851-862
WeiHuang,YungangHe,HaifengWang,YingWang,YangfanLiu,YiWang,XunChu,YingWang,LiangXu,YayunShen,XiaoyanXiong,HuiLi,BoWen,JiQian,WentaoYuan,ChenhuiZhang,YiWang,HongquanJiang,GuopingZhao,ZhuChenandLiJin.LinkageDisequilibriumSharingandHaplotype-taggedSNPPortabilitybetweenPopulations.PNAS,,2006,103(5):1418-1421
QinZan,BoWen,YungangHe,YiWang,ShuhuaXu,JiQian,DaruLuandLiJin.CompleteSequenceDataSupportLackofBalancingSelectiononPRNPinaNaturalChinesePopulation.JournalofHumanGenetics,,2006,51(5):451-454
JinyingZhao,LiJinandMomiaoXiong.TestforInteractionbetweenTwoUnlinkedLoci.TheAmericanJournalofHumanGenetics,,2006,79:831-845
2006before：
1.ChuJY,HuangW,KuangSQ,WangJM,XuJJ,ChuZT,YangZQ,LinKQ,LiP,WuM,GengZC,TanCC,DuRF,JinL.GeneticrelationshipofpopulationsinChina.PNAS.95:11763-11768,1998
2.SuB,XiaoJ,LuD,ChakrabortyR,JinL.AnHIV-resistantalleleisexceptionallyfrequentinNewGuineanhighlanders.JAMA280:1830,1998.
3.JinL,UnderhillPA,DoctorV,etal.Distributionofhaplotypesfromachromosome21regiondistinguishesmultipleprehistorichumanmigrations.PNAS96:3796-3800,1999
4.XiongM,JinL.Comparisonofthepowerandaccuracyofbiallelicandmicrosatellitemarkersinpopulation-basedgene-mappingmethods.AmJHumGenet64:629-40,1999
5.HaciaJG,J-BFan,ORyder,LJin,etal.Determinationofancestralallelesforhumansingle-nucleotidepolymorphismsusinghigh-densityoligonulceotidearrays.NatGenet22:164-167,1999
6.SuB,JinLetal.DistributionofTwoHIV-1ResistantPolymorphismsinEastAsiaandWorldPopulationsandItsImplicationinAIDSEpidemiology.AmJHumGenet65:1047-1053,1999
7.SuB,XiaoJ,UnderhillP,DekaR,ZhangW,AkeyJ,HuangW,ShenD,LuD,LuoJ,ChuJ,TanJ,ShenP,DavisR,Cavalli-SforzaLL,ChakrabortyR,XiongM,DuR,OefnerP,ChenZ,JinL.YchromosomeEvidenceforanorthwardmigrationofmodernhumansinEastAsiaduringthelastIceAge.AmJHumGenet65:1718-1724,1999
8.XiongM,JinL.Combinedlinkageandlinkagedisequilibriummappingforgenomescreens.GeneticEpidemiology.19:211-234,2000.
9.JinL,etal.Acomparisonoftwomicrosatellitedatasetsfromthesamehumanpopulations.AnnHumGenet.64:117-134,2000.
10.SuB,JinL,etal.Polynesianorigins:newinsightsfromtheY-chromosome.PNAS97:8225-8228,2000.
11.ZhaoZ,JinL,etal.WorldwideDNAsequencevariationina10kbnoncodingregiononhumanchromosome22.PNAS97:11354-11358,2000.
12.XiongM,JinL,LiW,BoerwinkleE.ComputationalMethodsforGeneExpression-BasedTumorClassification.Biotechniques29:1264-1270,2000.
13.UnderhillPA,ShenP,LinAA,JinL,etal.YChromosomeSequenceVariationandtheHistoryofHumanPopulations.NatureGenet26:358-361,2000.
14.SuB,XiaoC,DekaR,SeielstadMT,KangwanpongD,XiaoJ,LuD,UnderhillP,Cavalli-SforzaLL,ChakrabortyR,JinL.YchromosomehaplotypesrevealprehistoricalmigrationstotheHimalayas.HumGenet107:582-590,2000.
15.JinL,SuB.Nativesorimmigrants:originandmigrationsofmodernhumansinEastAsia.NatureRevGenet1:126-133,2001
16.KeY,SuB,SongX,LuD,MarzukiS,DekaR,WellsRS,LellJ,WallaceD,SeielstadM,MartinsonJ,ShriverMS,HuangW,ChakrabortyR,UnderhillPA,ChenZ,JinL.2000.AfricanoriginofmodernhumansinEastAsia:Ataleof12,000Ychromosomes.Science292:1151-1153.
17.JiangZ,AkeyJ,ShiJ,XiongM,WuH,XiaoJ,LuD,HuangW,JinL.Apolymorphisminthepromoterregionofcatalaseisassociatedwithbloodpressurelevels.HumGenet109:95-98.2001.
18.AkeyJM,ZhangK,XiongM,JinL.Theaffectofgenotypingerrorsontherobustnessofcommonlinkagedisequilibriummeasures.AmJHumGenet68:1147-1456.2001.
19.XiongM,LiW,ZhaoJ,JinL,BoerwinkleE.Feature(Gene)SelectioninGeneExpressionBasedTumorClassification.MolBiolMetab73:239-247.2001.
20.JinL,SuB.TheYchromosomeandthereplacementhypothesis–Response.Science293:567-567B.2001.
21.XiongM,FanR,JinL.2002.Linkagedisequilibriummappingofquantitativetraitlociundertruncationselection.HumHered.53:158-172.
22.AkeyDT,AkeyJM,ZhangK,JinL.2002.High-throughputmeltingcurvebasedapproachestoassayDNAmethylation.Genomics80:376-384.
23.WangN,JoshAM,ZhangK,ChakrabortyR,JinL.2002.Distributionofrecombinationcrossoversandtheoriginofhaplotypeblocks:theinterplayofpopulationhistory,recombination,andmutation.AmJHumGenet71:1227-1234.
24.AkeyJM,ZhangG,ZhangK,JinL,ShriverMD.2002.Interrogatingahigh-densitySNPmapforsignaturesofnaturalselection.GenomeRes.12:1805-1814.
25.ZhangK,AkeyJM,WangN,XiongM,ChakrabortyR,JinL.2003.Randomlydistributedcrossoversmaygenerateblock-likepatternsoflinkagedisequilibrium:anactofgeneticdrift.HumGenet113:51-59.
26.ZhangK,JinL.2003.HaploBlockFinder:Anefficientprogramforhaplotypeblockanalyses.Bioinformatics19:1-3.
27.ShiJ,XiH,WangY,ZhangC,JiangZ,ZhangK,ShenY,JinL,ZhangK,YuangW,WangY,LinJ,HuaQ,WangF,XuS,RenS,XuS,ZhaoG,ChenZ,JinL,HuangWei.2003.Divergenceofthegenesonhumanchromosome21betweenhumanandotherhominoidsandvariationofsubstitutionratesamongtranscriptionunits.PNAS100:8331-6.
28.WenB,XieX,GaoS,LiH,ShiH,SongX,QianT,XiaoC,JinJ,SuB,LuD,ChakrabortyR,JinL.2004.AnalysisofgeneticstructrureofTibeto-Burmanpopulationsrevealedagender-biasedadmixtureinSouthernTibeto-Burmans.AmJHumGenet74:856-865.
29.ZhangG,LuoJ,BruckelJ,WeismanM,SchumacherHR,KhanMA,InmanR,MahowaldM,MaksymowychW,MartinTM,YuDTY,StoneM,RosenbaumJT,NewmanP,LeeJ,McClainJA,WestOC,JinL,ReveilleJ.2004.Geneticstudiesinfamilialankylosingspondylitissusceptibility.ArthritisandRheumatism50:2246-2254.
30.WenB,LiH,LuD,SongX,ZhangF,HeY,LiF,GaoY,MaoX,ZhangL,QianJ,TanJ,JinJ,HuangW,DekaR,SuB,ChakrabortyR,JinL.2004.GeneticevidencesupportsdemicdiffusionofHanculture.Nature431:302-305
31.JinL,WeismanMA,ZhangG,AkeyJM,BruckelJ,InmanRD,LuoJ,KhanMA,SchumacherHR,MaksymowychWP,MahowaldML,SawitzkeAD,WaseyFB,YuDTY,StoneMA,LeeJ,ReveilleJD.2004.LackofassociationandlinkageofIL1RNgenotypeswithankylosingspondylitissusceptibility.ArthritisandRheumatism50:3047-3048.
32.JiangZ,DaltonTP,JinL,WanbB,TsuneokaY,ShertzerHG,DekaR,NebertDW.2005.Towardtheevaluationofunctioningeneticvariability:characterizinghumanSNPfrequenciesandestablishingBAC-transgenicmicecarryingthehumanCYP1A1_CYP1A2locus.HumanMutation25:196-206.
