在岗研究生导师情况介绍
所系名称计算生物学研究所
性别男
专业名称计算生物学
技术职务研究员
行政职务无
Mail地址tangkun@picb.ac.cn
指导博士
生总数0指导硕士
生总数0已毕业学生通讯地址上海市岳阳路320号计算生物学研究所
目前博士
生数1目前硕士
生数2目前在校生邮政编码200031
研究方向人类遗传多样性
研究工作Mymajorresearchinterestistolookforfunctionalhumangeneticvariationsandtounderstandtheirbiologicalmechanismandevolutionaryroles.Genetically,Peopledifferfromeachotherbyhundredthousandsofsmallgeneticvariations.Asmallfractionofthesegeneticvariationsaffectfunction.Theymakeusaphenotypicallyverydiversespecies.Suchphenotypediversityoccursamongpopulations,suchasskinpigmentationandlactosetoleranceinadulthoodetc.;andalsobetweenindividuals,suchasstature,weight,psychologicaltendencyanddrugmetabolism.
Tounderstandthesefunctionalgeneticvariations,twostrategiesaretobeapplied.Thefirstistodetectandcharacterizeevidencesofpositiveselection.
Thesecondstrategyistouseassociationrelatedapproaches.
获奖情况
指导研究
生情况
个人简介
1996-2000,B.S.,Biochemistry,JilinUniversity,Changchun,China
2001-2004,PhD,Biochemistry,NationalUniversityofSingapore,Singapore
DoctoralThesis:GeneticAnalysisofSNPsinandaroundMDR1Gene
PositionsandEmployment
2004-2007PostdoctoralFellow,Dept.ofGenetics,MaxPlanckInstituteforEvolutionaryAnthropology
近期论文SelectedPublications:
JingLi,LuyongZhang2,HangZhou,MarkStonekingandKunTang.GlobalPatternsofGeneticDiversityandSignalsofNaturalSelectionforHumanADMEGenes.Hum.Mol.Genet,doi:10.1093/hmg/ddq498
HerraezDL*,BauchetM*,TangK*,TheunertC,PugachI,etal*co-first-authors.GeneticVariationandRecentPositiveSelectioninWorldwideHumanPopulations:EvidencefromNearly1MillionSNPs.PlosOne4(11):art.no.-e7888.2009,
NasidzeI,QuinqueD,LiJ,LiMK,TangK,etal.Comparativeanalysisofhumansalivamicrobiomediversitybybarcodedpyrosequencingandcloningapproaches.AnalyticalBiochemistry391:64-68,2009,
Hughes,DA,TangK,StrotmannR,SchönebergT,PrenenJ,NiliusB,StonekingM.ParallelsoftsweepsonTRPV6inhumanpopulations.PLoSONE2008;inpress.
MylesS,TangK,SomelM,GreenRE,KelsoJ,StonekingM.Identificationandanalysisofgenomicregionswithlargebetween-populationdifferentiationinhumans.AnnalsHumanGenetics2008;72:99-110.
TangK,ThorntonKR,StonekingM.ANewApproachforUsingGenomeScanstoDetectRecentPositiveSelectionintheHumanGenome.PLoSBiol.2007Jun19;5(7):e171
MylesS,SomelM,TangK,KelsoJ,StonekingM.Identifyinggenesunderlyingskinpigmentationdifferencesamonghumanpopulations.HumGenet.2007Jan;120(5):613-21.
KhaitovichP,TangK,FranzH,KelsoJ,HellmannI,EnardW,LachmannM,PaaboS.
Positiveselectionongeneexpressioninthehumanbrain.CurrBiol.2006May23;16(10):R356-8.
ZhouY,TangK,LawHY,NgIS,LeeCG,ChongSS.FMR1CGGrepeatpatternsandflankinghaplotypesinthreeAsianpopulationsandtheirrelationshipwithrepeatinstability.AnnHumGenet.2006Nov;70(Pt6):784-96.
WangZ,WangB,TangK,LeeEJ,ChongSS,LeeCG.AfunctionalpolymorphismwithintheMRP1genelocusidentifiedthroughitsgenomicsignatureofpositiveselection.HumMolGenet.2005Jul15;14(14):2075-87.
GweePC,TangK,SewPH,LeeEJ,ChongSS,LeeCG.StronglinkagedisequilibriumatthenucleotideanaloguetransporterABCC5genelocus.PharmacogenetGenomics.2005Feb;15(2):91-104.
LeeCG,TangK,CheungYB,WongLP,TanC,ShenH,ZhaoY,PavanniR,LeeEJ,WongMC,ChongSS,TanEK.MDR1,theblood-brainbarriertransporter,isassociatedwithParkinson'sdiseaseinethnicChinese.JMedGenet.2004May;41(5):e60.
TangK,WongLP,LeeEJ,ChongSS,LeeCG.GenomicevidenceforrecentpositiveselectionatthehumanMDR1genelocus.HumMolGenet.2004Apr15;13(8):783-97.
GweePC,TangK,ChuaJM,LeeEJ,ChongSS,LeeCG.Simultaneousgenotypingofsevensingle-nucleotidepolymorphismsintheMDR1genebysingle-tubemultiplexminisequencing.ClinChem.2003Apr;49(4):672-6.
TangK,NgoiSM,GweePC,ChuaJM,LeeEJ,ChongSS,LeeCG.DistincthaplotypeprofilesandstronglinkagedisequilibriumattheMDR1multidrugtransportergenelocusinthreeethnicAsianpopulations.Pharmacogenetics.2002Aug;12(6):437-50.
