在岗研究生导师情况介绍
所系名称计算生物学研究所
性别男
专业名称计算生物学
技术职务研究员
行政职务无
Mail地址weigang@picb.ac.cn
指导博士
生总数0指导硕士
生总数0已毕业学生通讯地址上海市岳阳路320号
目前博士
生数0目前硕士
生数0目前在校生邮政编码200031
研究方向表观遗传组学
研究工作1.研究表观遗传组在细胞分化过程中的动态变化及其对基因表达的调控功能。
表观遗传修饰主要包括DNA甲基化和组蛋白修饰等方面，它可以通过调控染色质结构的变化显著影响基因转录水平。单一细胞类型中染色体上所有表观遗传修饰的组合称为表观遗传组。系统性的研究细胞发育以及疾病发生过程中表观遗传组的变化规律对于阐明染色质结构与功能之间的关系有着重要意义，并为进一步研究细胞发育和疾病发生的分子机理提供重要帮助。
2.通过大规模的染色质长距离的相互作用的分析，研究染色质高级结构的调控功能。
染色质的高级结构一直是研究者们感兴趣的问题，但由于缺乏有效的研究手段，人们无法系统性的研究全基因组规模的染色质高级结构。最近，一些创新性的研究方法包括ChIA-PET,Hi-C等的成功应用极大的推动了这一领域的研究。我们将利用这些技术手段，系统性的研究细胞分化过程中染色质高级结构的动态变化。同时，鉴定并研究参与调控染色质高级结构的蛋白因子，阐明染色质结构与功能之间的关系。
获奖情况
指导研究
生情况无
个人简介1996－2000北京大学学士
2000－2005北京大学博士
2005－2011美国国家健康研究院（NIH）博士后
2012－中科院上海生命科学研究院计算生物学研究所研究员，课题组长
近期论文SelectedPublications:
2012
1.IouriChepelev*,GangWei*,DaraWangsa,QingsongTangandKejiZhao(2012).Characterizationofgenome-wideenhancer-promoterinteractionsrevealsco-expressionofinteractinggenesandmodesofhigherorderchromatinorganization.CellResearch,doi:10.1038/cr.2012.15.(*Equalcontributiontothispaper)
2011
1.GangWei*,BrianAbraham*,RyojiYagi*,RajaJothi*,KairongCui,SuveenaSharma,LeelavatiNarlikar,DanialNorthrup,QingsongTang,WilliamPaul,JinfangZhuandKejiZhao(2011).Genome-wideanalysesoftranscriptionfactorGATA3-mediatedgeneregulationindistinctTcelltypes.Immunity,35:299-311.(*Equalcontributiontothispaper)
2.ZixiongXu,GangWei,IouriChepelev,KejiZhaoandGaryFelsenfeld(2011).MappingofINSpromoterinteractionsrevealsitsrolesinlong-rangeregulationofSYT8transcription.NatureStructural&MolecularBiology,18:372-378.
3.GangWeiandKejiZhao(2011).3C-basedmethodstodetectlong-rangechromatininteractions.FrontiersinBiology,6:76-81.
2010
1.QiangGan,IouriChepelev,GangWei,LamaTarayrah,KairongCui,KejiZhaoandXinChen(2010).DynamicregulationofalternativesplicingandchromatinstructureinDrosophilagonadsrevealedbyRNA-seq.CellReserch,20:763-783.
2.RyojiYagi,IlkkaJunttila,GangWei,JosephUrban,KejiZhao,WilliamPaulandJinfangZhu(2010).ThetranscriptionfactorGATA3activelyrepressesRUNX3protein-regulatedproductionofinterferon-γ.Immunity,32:507-517.
3.QiangGan,DustinSchones,SukEun,GangWei,KairongCui,KejiZhaoandXinChen(2010).Monovalentandunpoisedstatusofmostgenesinundifferentiatedcell-enrichedDrosophilatestis.GenomeBiology,11:R42.
4.HoushengHe,CliffordMeyer,HyunjinShin,ShannonBailey,GangWei,etalandShirleyLiu(2010).Nucleosomedynamicsdefinetranscriptionalenhancers.NatureGenetics,42:343-347.
2009
1.IouriChepelev*,GangWei*,QingsongTangandKejiZhao(2009).DetectionofsinglenucleotidevariationsinexpressedexonsofthehumangenomeusingRNA-Seq.NucleicAcidResearch,37:e106.(*Equalcontributiontothispaper)
2.LiyingGuo,GangWei,JinfangZhu,WeiLiao,WarrenLeonard,KejiZhaoandWilliamPaul(2009).IL-1familymembersandSTATactivatorsinducecytokineproductionbyTh2,Th17andTh1cells.ProcNatlAcadSciUSA,106:13463-13468.
3.ChunyuanJin,ChongzhiZang,GangWei,KairongCui,WeiqunPeng,KejiZhaoandGaryFelsenfeld(2009).ChromatinarchitectureorganizedbyhistonevariantsH3.3andH2A.Zinthehumangenome.NatureGenetics,41:941-945.
4.JinfangZhu,ToddDavidson,GangWei,DraganaJankovic,KairongCui,DustinSchones,LiyingGuo,KejiZhao,EthanShevachandWilliamPaul(2009).Down-regulationofGfi-1expressionbyTGF-βisimportantfordifferentiationofTh17andCD103+inducibleregulatoryTcells.JournalofExperimentalMedicine,206:329-341.
5.GangWei*,LaiWei*,JinfangZhu,ChongzhiZang,JaneHu-Li,ZhengjuYao,KairongCui,YukaKanno,Tae-YoungRoh,WendyWatford,DustinSchones,WeiqunPeng,HongweiSun,WilliamPaul,JohnO’SheaandKejiZhao(2009).GlobalmappingofH3K4me3andH3K27me3revealsspecificityandplasticityinlineagefatedeterminationofdifferentiatingCD4+Tcells.Immunity,30:155-167.(*Equalcontributiontothispaper)
2008
1.DustinSchones,KairongCui,SureshCuddapah,Tae-YoungRoh,ArternBarski,ZhibinWang,GangWeiandKejiZhao(2008).Dynamicregulationofnucleosomepositioninginthehumangenome.Cell,132:887-898.
2007
1.Arternbarski*,SureshCuddapah*,KairongCui*,Tae-YoungRoh*,DustinSchones*,ZhibinWang*,GangWei*,IouriChepelevandKejiZhao(2007).High-resolutionprofilingofhistonemethylationsinhumangenome.Cell,129:823-837.(*Theseauthorscontributedequallytothisworkandarelistedalphabetically)
2.Tae-YoungRoh*,GangWei*,CatherineFarrelandKejiZhao(2007).Genome-widepredictionofconservedandnonconservedenhancersbyhistoneacetylationpatterns.GenomeResearch,17:74-81.(*Equalcontributiontothispaper)
2005andbefore
1.GangWei,JuanLei,WeiGongandYu-XianZhu(2005).Molecularcloning,expressionalprofiling,DNA-bindingandtransactivationpropertiesofQRAP2fromArabidopsis.ChineseScienceBulletin,50:1873-1878.
2.GangWei,YiPan,JuanLeiandYu-XianZhu(2005).Molecularcloning,phylogeneticanalysis,expressionalprofilingandinvitrostudiesofTINY2fromArabidopsisthaliana.JournalofBiochemistryandMolecularBiology,38:440-446.
3.Jian-XunFeng,Sheng-JianJi,Yong-HuiShi,YuXu,GangWeiandYu-XianZhu(2004).Analysisoffivedifferentiallyexpressedgenefamiliesinfastelongatingcottonfiber.ActaBiochemistryandBiophysicsSinica.36:51-56.
4.Sheng-JianJi,Ying-ChunLu,Jian-XunFeng,GangWei,JunLi,Yong-HuiShi,QiangFu,DiLiu,Jing-ChuLuoandYu-XianZhu(2003).IsolationandanalysesofgenespreferentiallyexpressedduringearlycottonfiberdevelopmentbysubtractivePCRandcDNAarray.NucleicAcidsResearch,31:2534-43.
5.Sheng-JianJi,Ying-ChunLu,JunLi,GangWei,Xiu-JuanLiangandYu-XianZhu(2002).Aβ-tubulin-likecDNAexpressedspecificallyinelongatingcottonfibersinduceslongitudinalgrowthoffissionyeast.BiochemicalandBiophysicalResearchCommunications,296:1245-1250.
6.Ying-ChunLu,GangWeiandYu-XianZhu(2002).Cloningthewholecellulose-synthesizingoperon(ayacsoperon)fromAcetobacterxylinumandtransformingitintocultivatedcottonplants.ActaBotanicaSinica,44:441-445.
