在岗研究生导师情况介绍
所系名称计算生物学研究所
性别男
专业名称计算生物学
技术职务研究员
行政职务无
Mail地址junyan@picb.ac.cn
指导博士
生总数0指导硕士
生总数0已毕业学生通讯地址上海市岳阳路320号计算生物学研究所
目前博士
生数5目前硕士
生数3目前在校生邮政编码200031
研究方向功能基因组学
研究工作CurrentstateofResearch
Mammalianhibernatorsachievedtheamazinggoalofenergysavingbyactivelysuppressingtheirmetabolicratesundertheextremeenvironmentalconditions.Theyhaveevolvedremarkableabilitiestosustaintherespiratory,cardiovascular,immunological,andneurologicalresponsestometabolicsuppressionduringhibernationthatwouldbelifethreateninginothermammalianspecies.Understandingthemolecularmechanismunderlyingthehibernationphenotypecanprovidethecrucialcluestothedevelopmentofnoveltherapeuticinterventionstohumandiseases.Arcticgroundsquirrel(Spermophilusparryii)providesanexcellentanimalmodeltostudyhibernation.Duringthe6-9monthslonghibernationseason,arcticgroundsquirrelsenterthestateoftorporbyloweringtheircorebodytemperaturestoaslowas–2.9C.However,theyspontaneouslyre-warmtoeuthermicbodytemperatures(36-37C)every10-21daysandmaintainthattemperaturefor15-24hoursbeforeslowlyre-enteringtorpor.Allsmallmammalianhibernatorsexhibitperiodicarousalsfromtorporinspiteoftheexpensiveenergycost.Thefunctionofarousalepisodeshasbeenlargelyunknown.Leadingtheoriesincludethathibernatorsarousetosleepandtoreplenishtheirgeneproducts.Unveilingthebiochemicalprocessesinthetorpor-arousalcyclesinhibernatorswouldhelpustodesignnewtreatmentsforhumanconditionslikestroke,ischemia,andreperfusion.
CollaboratingwiththeresearchersatInstituteofArcticBiologyinUniversityofAlaskaFairbanks,wepreviouslyidentifiedthedifferentialexpressionof625genesinbrownadiposetissue(BAT)withthelarge-scalemousemicroarrayscomparingwintertorpidwithsummeractivearcticgroundsquirrels.Amongthem,thegenesinvolvedinnon-shiveringthermogenesis(NST)weresignificantlyup-regulatedwhereasthoseinvolvedinproteinsynthesisweresignificantlydown-regulated(Yanetal.2006).Followingupthisstudy,weperformedalarge-scalescreeningofdifferentialgeneexpressioninawiderangeoftissuesincludingbrownadiposetissue,liver,heart,hypothalamus,andskeletalmuscleinhibernatingarcticgroundsquirrelscomparingfourstagesintorpor-arousalcyclesandnon-hibernatinganimalsusingbothhigh-throughputilluminabeadarraytechnologyandReal-timePCRassay(Manuscriptinpreparation).Significantseasonaldifferencesofgeneexpressionaredetectedinthegenesinvolvedinglycolysis,fattyacidmetabolism,gluconeogenesis,amino-acidmetabolism,transport,detoxication,cardiaccontractility,circadianrhythms,muscledystrophy,andRNAprotectionetc.invarioustissuescomparingtorpidandarousedanimalswithnon-hibernatinganimals.OurresultscastdoubtonthehypothesisthatmammalianhibernatorsarousetoreplenishtheirgeneproductsonthemRNAlevel.Instead,weobserved,forthefirsttime,complexmodulationofgeneexpressionduringmultiplestagesoftorpor-arousalcycles.Inparticular,mostsignificantdifferencesofgeneexpressionduringtorpor-arousalcyclesarefoundduringthetransitionfromlatetorportoearlyarousal.Duringthistransition,themRNAlevelofagroupofmetabolicgenessignificantlydropsperhapsduetotheexhaustionofmRNAtranscriptsduringtheenergeticearlyarousalphase,whereasthemRNAlevelforthegenesrelatedtocellgrowthandproliferationrisessharplywhichmayreflecttheresumptionofcellcycleduringarousalthathasbeenstalledduringtorpor.
获奖情况
指导研究
生情况
个人简介1994—1998DepartmentofphysicsFudanUniversityBachelor
1998---2003NewYorkUniversity，USAPh.D
2003---2005UniversityofAlaskaFairbanks.USAPostdoc.
2006---InstituteforComputationalBiologyPI
近期论文SelectedPublications：
Guang-jiongNi,HongGuan,Wei-minZhou,andJunYan,AntiparticleinthelightofEinstein-Podolsky-RosenParadoxandKleinParadox,ChinesePhysicsLetters,Vol.17,No.6,2000,393-395
JunYan,HarmonicInteractionModelandItsApplicationsinBose-EinsteinCondensation,JournalofStatisticalPhysics,Vol.113,Nos.3/4,Nov.2003,623-634
K.K.Mon,J.K.Percus,andJunYan,QuasiOne-DimensionalSelf-Diffusion,MolecularSimulation,Vol.29(12),Dec.2003,721-726
JunYanandThomasG.Marr,Computationalanalysisof3’-endsofESTsshowsfourclassesofalternativepolyadenylationinhuman,mouse,andrat,GenomeResearch,Vol.15,2005,369-375
JunYan,AdlaiBurman,CalenNichols,LindaAlila,LouiseC.Showe,MichaelK.Showe,BertB.Boyer,BrianM.Barnes,andThomasG.Marr,Detectionofdifferentialgeneexpressionin brownadiposetissueofhibernatingarcticgroundsquirrelswithmouse microarrays.PhysiolGenomics25:346-353,2006.
