黄诚 研究员
研究领域：
抗肿瘤和治疗内分泌代谢性疾病的药物筛选和新靶点的鉴定
个人简历
上海中医药大学，中药学院，研究员。目前从事抗肿瘤和治疗内分泌代谢性疾病的药物筛选和新靶点的鉴定，旨在从中药中发现具有减肥、降血糖、降血脂和抗肿瘤作用的新化合物或复方中药。共发表论文60余篇。
受教育经历
?1994/9-1997/7，上海中医药大学，博士
?1987/9-1990/7，上海中医药大学，硕士
?1979/10-1982/10，扬州大学医学院
研究工作经历
?2009/7-至今，上海中医药大学中药学院，研究员
?2006/11-2007/5，美国肯塔基大学医学院，访问科学家
?2005/7-2009/7，中国科学院营养科学研究所，副研究员
?2002/11-2005/6，美国贝勒医学院分子与人类遗传系，Research Associate
?2001/6-2002/11，美国贝勒医学院儿科系，博士后
?1999/9-2001/6，中国科学院上海生理研究所，副研究员
?1997/9-1999/9，中国科学院上海生理研究所，博士后
?1990/7-1997/9，上海市针灸经络研究所，助理研究员/副研究员
所获荣誉、奖项
?1. 季光，王峥涛，黄诚，刘建文，王淼，吴涛，杨丽丽，张莉，宋海燕，柳涛，孙姗姗，范圣洁，魏华凤，郑培永，邢练军，安红梅，王磊，励冬斐，刘洋，潘洁露，舒祥兵，徐汉辰。基于病证结合中医药治疗非酒精性脂肪肝的转化医学研究，教育部，科技进步奖，二等奖，2014年1月。
?2. 季光，张莉，魏华凤，宋海燕，郑培永，刘建文，黄诚，杨丽丽，王淼，柳涛，杨莉，安红梅，吴涛，邢练军，王磊。 基于病证结合中医药治疗非酒精性脂肪肝的转化医学实践，上海市，科学技术奖，一等奖，2013年12月12日。
科研领域
该实验室主要科研重点是有关代谢性疾病和肿瘤相关的药物研发和机制研究。通过建立3T3-L1脂肪细胞分化筛选平台、报告基因核受体筛选平台、肿瘤细胞筛选平台以及体内药效学筛选平台等，从中草药、复方、药食两用植物和天然产物中筛选具有明显减肥、降血糖、降血脂、防治动脉粥样硬化以及恶性肿瘤的前体药物，并对其进行相关靶点的机制研究。以期填补中药在阐明机制方面的不足。通过构建基因敲除、转基因等动物模型，开发新的药物靶点。为中医药防治代谢综合征和肿瘤提供科学理论依据及临床基础。
学术论文
1.Liu G, Zhang Y, Liu C, Xu D, Zhang R, Cheng Y, Pan Y, Huang C, Chen Y. Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. J Nutr. 144(7): doi: 10.3945/jn.114.193128. (2014).
2.Huang C*. Natural modulators of liver X receptors. J Integr Med. 7(2):76-85, (2014).
3.Fan S, Zhang Y, Sun Q, Zheng B, Wu X, Yang B, Li Y, Huang C*. Extract of okra lowers blood glucose and serum lipids in high-fat diet induced obese C57BL/6 mice. J Nutr Biochem. 25: (2014).
4.Tan S, Li M, Ding X, Fan S, Guo L, Gu M, Zhang Y, Feng L, Jiang D, Li Y, Xi W, Huang C*, Zhou Z*. Effects of Fortunella margarita fruit extract on metabolic disorder in high-fat diet-induced obese C57BL/6 mice. PLoS One. 9(4): e93510, (2014).
5.Li J, Zhang L, Huang C, Guo F, Li Y. Five new cyotoxic steroidal glycosides from the fruits ofSolanum torvum. Fitoterapia. 93: 209-215, (2014).
6.Lu Y, Xi W, Ding X, Fan S, Zhang Y, Jiang D, Li Y, Huang C*, Zhou Z*. Citrange fruit extracts alleviate obesity-associated metabolic disorder in high-fat diet induced C57BL/6 mouse. Int J Mol Sci. 14:23736-23750, (2013).
7.Feng L, Liu X, Zhu W, Guo F, Wu Y, Wang R, Chen K, Huang C*, Li Y*. Inhibition of human neutrophil elastase by pentacyclic triterpenes. PLoS One. 8(12): e82794, (2013).
8.Gu M, Zhang Y, Fan S, Ding X, Ji G*, Huang C*. Extracts of Rhizoma Polygonati Odorati prevent high-fat diet-induced metabolic disorders in C57BL/6 mice. PLoS One. 8(11):e81724, (2013).
9.Ding X, Guo L, Zhang Y, Fan S, Gu M, Lu Y, Jiang D , Li Y*, Huang C*, Zhou Z*. Extracts of pomelo peels prevent high-fat diet-induced metabolic disorders in C57BL/6 mice through activating the PPARα and GLUT4 pathway. PLoS One. 8(10):e77915, (2013).
10.Fan S, Guo L, Zhang Y, Sun Q, Yang B, Huang C*. Okra polysaccharide improves metabolic disorders in high-fat diet-induced obese C57BL/6 mice. Mol Nutr Food Res. 57:2075-2078, (2013).
11.Jing L, Zhang Y, Fan S, Gu M, Guan Y, Lu X, Huang C*, Zhou Z*. Preventive and ameliorating effects of citrus d-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity. Eur J Pharmacol. 715:46-55, (2013).
12.Guo F, Feng L, Huang C, Ding H, Zhang X, Wang Z, Li Y. Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo. Phyto Lett. 6:331-336, (2013).
13.Hu N, Yuan L, Li H-J, Huang C, Mao Q-M, Zhang Y-Y, Lin M, Sun Y-Q, Zhong X-Y, Tang P, Lu X. Anti-diabetic activities of Jiaotaiwan in db/db mice by augmentation of AMPK protein activity and up-regulation of GLUT4 expression. Evid-Based Compl Alt Med. 180721, (2013).
14.顾明, 黄诚*. 减肥药研发: 窘境背后的希望. 中国新药杂志. 22(5): 535-541, (2013).
15.Feng Q, Gou XJ, Meng SX, Huang C, Zhang YQ, Tang YJ, Wang WJ, Xu L, Peng JH, Hu YY. Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase In Vivo and In Vitro. Evid-Based Compl Alt Med. 184358, (2013).
16.Gu M, Fan S, Liu G, Guo L, Ding X, Lu Y, Zhang Y, Ji G, Huang C*. Extract of wax gourd peel prevents high-fat diet-induced hyperlipidemia in C57BL/6 mice via the inhibition of the PPARγ pathway. Evid-Based Compl Alt Med. 342561, (2013).
17.Fan S, Zhang Y , Hu N, Sun Q, Ding X, Li G, Zheng B, Gu M, Huang F, Sun Y-Q, Zhou Z, Lu X, Huang C*, Ji G*. Extract of kuding tea prevents high-fat diet-induced metabolic disorders in C57BL/6 mice via liver X receptor (LXR) β antagonism. PLoS One. 7(12): e51007, (2012).
18.Ding X, Fan S, Lu Y, Zhang Y, Gu M, Zhang L , Liu G, Guo L, Li Y, Lu X, Zhou Z*, Huang C*. Citrus ichangensis peel extract exhibits anti-obesity effects by the inhibition of PPARγ and LXR signaling in high-fat diet-induced C57BL/6 mouse. Evid-Based Compl Alt Med. 678592, (2012).
19.Zhang L, Fan S, Liu H, Huang C*. Targeting SMARCAL1 as a novel strategy for cancer therapy. Biochem Biophys Res Commun. 427:232-235, (2012).
20.Zhang Y, Fan S, Hu N, Gu M, Chu C, Li Y, Lu X, Huang C*. Rhein reduces fat weight in db/db mouse and prevents diet-induced obesity in C57BL/6 mouse through the inhibition of PPARγ signaling. PPAR Res. 374936, (2012).
21.Li Y, Huang W, Huang S, Du J*, Huang C*. Screening of anti-cancer agent using zebrafish: Comparison with the MTT assay. Biochem Biophys Res Commun. 422:85-90, (2012).
22.Zhang Y, Huang C*. Targeting adipocyte apoptosis: A novel strategy for obesity therapy. Biochem Biophys Res Commun. 417:1-4, (2012)
23.Wang P, Guo F, Tan J, Huang C, Wang G, Li Y. A novel C29 sterol from Clerodendrum cyrtophyllum. Chem Nat Comp. 48:594-596, (2012).
24.Feng L, Zhu W, Huang C, Li Y. Direct interaction of ONO-5046 with human neutrophil elastase through 1H NMR and molecular docking. Int J Biol Macromo. 51:196-200, (2012).
25.Gao N, Cheng S, Budhraja A, Gao Z, Chen J, Liu E-H, Huang C, Chen D, Yang Z, Liu Q, Li P, Shi X, Zhang Z. Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway. Br J Pharmacol. 165:1813-1826, (2012).
26.Wang Y, Feng L, Zhang B, Wang X, Huang C, Li Y, Du W. Palladium complexes affect the aggregation of human prion protein PrP106-126. Inorg Chem. 50:4340-4348, (2011).
27.Gao N, Budhraja A, Cheng S, Liu E-H, Huang C, Chen J, Yang Z, Chen D, Zhang Z, Shi X. Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo. Apoptosis. 16:511-523, (2011).
28.李乙根，黄文瑾，黄诚*. 斑马鱼在新药发现中的应用。生命科学， 23:273-278, (2011).
29.Chen C, Zhang Y, Huang C*. Berberine inhibits PTP1B activity and mimics insulin action. Biochem Biophys Res Commun. 397:543- 547, (2010).
30.Huang C*, Gu S, Yu P, Yu F, Feng C, Gao N, Du J. Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish. Dev Biol. 339:89-100, (2010).