研究领域：
中药新型经皮给药系统；
中药经穴给药机制；
中药经皮给药制剂新材料
邮箱：analysisdrug@126.com
个人简介：
张永太，博士，教授，研究生导师。
2005年进入上海中医药大学工作。美国密歇根大学安娜堡分校访问****、复旦大学访问****。在学术期刊上发表学术论文约100篇，其中SCI论文50余篇。曾获上海市科技进步奖、中华医学科技奖、上海中医药大学十大杏林菁英和“杏林****”等奖励与荣誉，入选上海中医药大学首批荣誉体系“****”称号。
承担课程：
承担《中药药剂学》、《中药制药辅料学》、《综合性实验》和《中药药剂学实验》、《医院药学实习》等课程的教学工作。
科研领域：
主要从事中药新型给药系统与经穴给药理论的研究：（1）对新型递药载体在中药经皮与经穴给药中的应用与机制进行了广泛而深入的探索，成功将可溶性微针、聚合物微针、新型脂质纳米载体用于中药经皮与穴位给药系统的构建，并采用多组学联用手段，从分子、蛋白与基因水平入手，结合外泌体信号传导，阐释微针等新型给药系统穴位给药通过“神经-免疫-炎性因子”效应轴发挥经穴效应的机理；（2）挖掘具有“药辅合一”特色的中药药/辅材料，开发新型经皮给药系统，如中药挥发油作为促透剂、新型纳米制剂的油相，天然材料如白及多糖、桃胶等作为微针基质，以及新型凝胶材料的开发利用等；（3）建立了数十种中药复方、有效组分及活性成分的新型经皮给药系统，尤其针对脂质纳米粒、新型脂质体与微乳及纳米载体与微针联用技术进行了深入研究；（4）建立了基于Nanosight示踪技术、光电显微镜技术、光谱技术与组学联合的中药新型经皮给药系统评价体系。发表相关SCI论文50余篇，主编和副主编专著4部，主持国家自然科学基金项目及省部级项目10余项，入选国家中医药管理局“中药特色技术传承人才”、上海市“杏林专门人才”等国家与省级人才计划，获上海人才发展资金资助。
学术论文：
1.Zhang S#, Zhang Y#, Wang Z, Guo T, Hou X, He Z, He Z, Shen L, Feng N*. Temperature-sensitive gel-loaded composite nanomedicines for the treatment of cervical cancer by vaginal delivery. Int J Pharm. 2020 Aug 30;586:119616.
2.Li Z#, Zhang Y#, Zhu C, Guo T, Xia Q, Hou X, Liu W, Feng N*. Folic acid modified lipid-bilayer coated mesoporous silica nanoparticles co-loading paclitaxel and tanshinone IIA for the treatment of acute promyelocytic leukemia. Int J Pharm. 2020 Aug 30;586:119576.
3.Zhang Y#, Zhang H#, Zhang K#, Li Z, Guo T, Wu T, Hou X, Feng N*. Co-hybridized composite nanovesicles for enhanced transdermal eugenol and cinnamaldehyde delivery and their potential efficacy in ulcerative colitis. Nanomedicine. 2020 Aug;28:102212. doi: 10.1016/j.nano.2020.102212.
4.Zhang Y#, Jing Q#, Hu H#, He Z, Wu T, Guo T, Feng N*. Sodium dodecyl sulfate improved stability and transdermal delivery of salidroside-encapsulated niosomes via effects on zeta potential. Int J Pharm. 2020 Apr 30;580:119183.
5.Zhang Y#, Hu H#, Jing Q#, Wang Z, He Z, Wu T, Feng NP*. Improved Biosafety and Transdermal Delivery of Aconitine via Diethylene Glycol Monoethyl Ether-Mediated Microemulsion Assisted with Microneedles. Pharmaceutics. 2020 Feb 17;12(2):163.
6.Zhang Y#, Zhang K#, Wang Z#, Hu H, Jing Q, Li Y, Guo T, Feng N*. Transcutol? P/Cremophor? EL/Ethyl Oleate-Formulated Microemulsion Loaded into Hyaluronic Acid-Based Hydrogel for Improved Transdermal Delivery and Biosafety of Ibuprofen. AAPS PharmSciTech. 2019 Dec 10;21(1):22.
7.Li YY#, Zhang YT#, Li Z, Zhou K, Feng NP*. Exosomes as Carriers for Antitumor Therapy. ACS Biomater Sci Eng. 2019 Aug 19; 5(10):4870-4881.
8.He Z#, Zhang Y#, Feng N*. Cell membrane-coated nanosized active targeted drug delivery systems homing to tumor cells: A review. Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110298.
9.Zhang K#, Zhang Y#, Li N, Xing F, Zhao J, Yang T, Liu C, Feng N*. An herbal- compound-based combination therapy that relieves cirrhotic ascites by affecting the L-arginine/nitric oxide pathway: A metabolomics-based systematic study. J Ethnopharmacol. 2019 Sep 15;241:112034.
10.Xia Q#, Zhang Y#, Li Z, Hou X, Feng N*. Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application. Acta Pharm Sin B. 2019 Jul;9(4):675-689.
11.Zhang Y#, Xia Q#, Li Y#, He Z, Li Z, Guo T, Wu Z, Feng N*. CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin. Theranostics. 2019 Jan 1;9(1):48-64.
12.Zhang YT#, Zhang K#, Li Z, Zhang HY, Guo T, Li YY, Zhao JH, Feng NP*. DOC-LS, a new liposome for dermal delivery, and its endocytosis by HaCaT and CCC-ESF-1 cells. IET Nanobiotechnol. 2018 Dec;12(8):1037-1041.
13.Zhang YT, Wang Z, Shen LN, Li YY, He ZH, Xia Q, Feng NP*. A novel microemulsion-based isotonic perfusate modulated by Ringer's solution for improved microdialysis recovery of liposoluble substances. J Nanobiotechnology. 2018 Nov 14;16(1):91.
14.Fan Q#, Zhang Y#, Hou X, Li Z, Zhang K, Shao Q, Feng N*. Improved oral bioavailability of notoginsenoside R1 with sodium glycocholate-mediated liposomes: Preparation by supercritical fluid technology and evaluation in vitro and in vivo. Int J Pharm. 2018 Dec 1;552(1-2):360-370.
15.Li Z#, Zhang Y#, Zhang K, Wu Z, Feng N*. Biotinylated-lipid bilayer coated mesoporous silica nanoparticles for improving the bioavailability and anti-leukaemia activity of Tanshinone IIA. Artif Cells Nanomed Biotechnol. 2018;46(sup1):578-587.
16.Zhang YT#, Li Z#, Zhang K, Zhang HY, He ZH, Xia Q, Zhao JH, Feng NP*. Co-delivery of evodiamine and rutaecarpine in a microemulsion-based hyaluronic acid hydrogel for enhanced analgesic effects on mouse pain models. Int J Pharm. 2017 Aug 7;528(1-2):100-106.
17.Zhang H, Zhang K, Li Z, Zhao J, Zhang Y*, Feng N*. In Vivo Microdialysis for Dynamic Monitoring of the Effectiveness of Nano-liposomes as Vehicles for Topical Psoralen Application. Biol Pharm Bull. 2017;40(11):1996-2000.
18.Zhang Y, Li Z, Zhang K, Yang G, Wang Z, Zhao J, Hu R, Feng N*. Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans-ferulic acid ascompared with conventional solid lipid nanoparticles. Int J Pharm. 2016 Sep 10;511(1):57-64.
19.Zhang Y, Shen L, Zhang K, Guo T, Zhao J, Li N, Feng N*. Enhanced antioxidation via encapsulation of isooctyl p-methoxycinnamate with sodium deoxycholate-mediated liposome endocytosis. Int J Pharm. 2015 Dec 30;496(2):392-400.
20.Zhang YT#, Han MQ#, Shen LN, Zhao JH, Feng NP*. Solid Lipid Nanoparticles Formulated for Transdermal Aconitine Administration and Evaluated In Vitro and In Vivo. J Biomed Nanotechnol. 2015 Feb;11(2):351-61.
21.Zhang Y, Zhang K, Guo T, Li Y, Zhu C, Feng N*. Transdermal baicalin delivery using diethylene glycol monoethyl ether-mediated cubic phase gel. Int J Pharm. 2015 Feb 1;479(1):219-26.
22.Zhang Y, Zhang K, Wu Z, Guo T, Ye B, Lu M, Zhao J, Zhu C, Feng N*. Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake. Int J Pharm. 2015 Jan 15;478(1):138-146.