副 教 授


许祯，副教授，硕士生导师

联系方式：
地址: 上海宝山区南陈路333号，上海大学生命科学院，邮编：200444
信箱： xuz1@shu.edu.cn
电话：
教育背景:
2003 - 2009 博士后，生物化学，美国西部保留地大学/美国克利夫兰临床医院
1998 - 2003 博士，蛋白大分子结构生物学，中国科学院上海生命科学院
1994 - 1998 理学学士，微生物学，山东大学生命科学院
研究方向:
整合素信号网络中关键调控蛋白因子结构和功能研究、基于重要功能蛋白因子三维结构的抗癌和抗栓小分子药物的设计和开发
学术团体会员:
美国晶体学会、美国血液学会
论文发表:
1. Xu Z, Jiang WH, Jiao RS, Yang YL. Cloning, sequencing and high expression in Escherichia coli of D-hydantoinase gene from Burkholderia pickettii. Journal of Bioengineering 2002, 18(2):149-54.
2. Xu Z, Liu YQ, Yang YL, Jiang WH, Arnold E, Ding JP. Crystal structure of D-hydantoinase from Burkholderia pickettii at a resolution of 2.7 angstroms: insights into the molecular basis of enzyme thermostability. Journal of Bacteriology 2003, 185(14): 4038-4049.
3. Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. Journal of Biological Chemistry 2004, 279(32): 33946-57.
4. Adikesavan N.V, Mahmood S.S, Stanley N, Xu Z, Wu N, Thibonnier M and Shoham M. A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein. Acta Crystallographica Section F 2005, 61(Pt4): 341-345
5. Macion-Dazard R, Callahan N, Xu Z, Wu N, Thibonnier M and Shoham M. Mapping the binding site of six nonpeptide antagonists to the human V2-renal vasopressin receptor. Journal of Pharmacology and Experiment Therapeutics 2006, 316(2): 564-71
6. Xu Z, Devlin K.I, Ford M.G, Nix J.C, Qin J, Misra S. Structure and interactions of the helical and U-box domains of CHIP, the C-terminus of Hsp70 interacting protein. Biochemistry 2006, 45: 4749-4759
7. Xu Z, Devlin K.I, Misra S. Structure of CHIP, a novel chaperone-associated ubiquitin ligase. (2006 ACA annual meeting)
8. Wu N, Macion-Dazard R, Nithianantham S, Xu Z and Vishnivetshiy S.A, Gurevich V.V, Thibonnier M and Shoham M. Soluble mimics of the cytoplasmic face of the human V1-vascular vasopressin receptor bind arrestin2 and calmodulin. Molecular Pharmacology 2006, 70:249-258
9. Xu Z, Kohli E, Devlin K.I, Bold M, Nix J.C, Misra S. Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes. BMC Structure Biology 2008, May 16, 8:26
10. Das B, Gupta S, Vasanji A, Xu Z, Misra S, Sen S. Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth: Regulation by myotrophin. Journal of Biological Chemistry 2008 283(41):27947-56
11. Xu Z, Page R, Gomes M, Kohli E, Nix J.C, Herr A, Patterson C, Misra S. Structural basis of nucleotide exchange and client binding by the novel Hsp70-cochaperone Bag2. Nature Structural and Molecular Biology 2008 15(12): 1309-17(Must Read as cited by Falcuty1000)
12. Smith L*, Page R*, Xu Z*, Kohli E, Litman P, Nix J, Ithychanda S, Liu J, Qin J, Misra S, Liedtke C Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator(CFTR) and immunoglobulin-like repeats of Filamin. Journal of Biological Chemistry 2010, 285(22):17166-76 (*equal contribution)
13. Liu J*, Fukuda K*, Xu Z*, Ma YQ, Hirbawi J, Mao X, Wu C, Plow EF, Qin J. Structural basis of phosphoinositide binding to kindling-2 protein pleckstrin homology domain in regulating integrin activation. Journal of Biological Chemistry 2011 286(50): 43334-42(*equal contribution)
14. Page Richard C, Xu Z, Amick J,Nix J, Misar S Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculus. Acta Crystallographica Section F, 2012 F 68: 647-651
15. Bledzka K, Liu JM, Xu Z, Perera D, Yadav S, Bialokowske K, Qin J, Ma YQ, Plow EF. Spatial coordination of kindlin-2 with talin head domain in interaction with integrin ? cytoplasmic tails. Journal of Biological Chemistry 2012, 287（29）：24585－94
16. Xu Z, Gao J, Hong J, Ma YQ. Integrity of kindling-2 FERM subdomains is required for supporting integrin activation. Biochem Biophys Res Commun 2013, May3, 434(2):382-7
17. Xu Z, Chen X, Zhi H,Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC, Liu J, Plow EF, Ma YQ. Direct interaction of Kindlin-3 with integrin aIIbb 3 in platelets is required for supporting arterial thrombosis in mice. Arterioscler Thromb Vasc Biol 2014, 34(9):1961-7.
18. Xu, Z, Cai, J., Gao, J., White, G.C., Chen, F. and Ma Y.Q. (2015) Interaction of kindlin-3 and β2-integrins differentially regulates neutrophil recruitment and NET release in mice. Blood 126(3):373-7. PMID: **
19. Gao J., Huang M., Lai J., Mao K., Sun P., Cao Z , Hu, Y., Zhang Y., Schulte M.L., Jin C., Wang J., White G., Xu Z. and Ma Y.Q. (2017) Kindlin supports integrin αIIbβ3 activation by interacting with paxillin. Journal of Cell Science 30(21): 3764-75.
20. Xu Z., Ni B., Cao Z., Zielonka J., Gao J., Chen F., Kalyanaramin B., White G. and Ma Y.Q. (2018) Neutrophil kindlin-3 acts as a negative regulator for ROS/NET generation. Journal of Leukocyte Biology 104(3): 597-602.
21. Cao Z., Suo X., Chu Y., Xu Z., Bao Y., Miao C., Deng W., Mao K., Gao J., Xu Z. and Ma Y.Q. (2018) Peptides derived from the integrin β cytoplasmic tails inhibit angiogenesis. Cell Communication and Signaling 16(1): 38.