讲 师



HUANG, hai (黄海), Ph.D.
Lecturer



Hai HUANG received his Ph.D. in Physiology from the Chinese University of Hong Kong , Hong Kong Special Administrative Region, in 2003. He received his undergraduate degree from the Nanchang University, China, in 1993 and his master degree of science in Cell Biology from the Chinese Academy of Sciences, China , in 1997. He then joined the faculty of School of Life Sciences in 1996 and was appointed lecturer in 1999.
The current research of his group focuses on cellular signaling transduction networks initiated by stress. One program is designed to address the molecular pathogenesis of Parkinson’s disease linked to alpha-synuclein mutation and Alzheimer’s disease. The second project is to investigate the physiological response of cell to trichosanthin, a ribosome inactivating protein isolated from the Chinese medicinal herb Trichosanthes kirilowii Maximowicz.

Publications:
1. Ju XC, Wang HF, Wu J, Huang H, Wen TQ,2011. Prokaryotic Expression and Purification of Mouse Recombinant Dendritic Cell-derived Factor 1-DCF1. Biotechnology 21(1):23-25 (Chinese).
2. Yu T, Huang H, Li HF, 2010. Stromal cell-derived factor (SDF-1) promotes migration of cells from upper rhombic lip in cerebellar development. J Neuroscience Research 88(13):2775-86.
3. Huang H, Yu T, Favreau B, Wen TQ, Zhu ZF, 2010. Practice on teaching innovation in immunology course. J Shanghai University (Higher Education Science and Administration) 3:21-22（Chinese）.
4. Liu X, Ren X, Deng X, Huo Y, Xie J, Huang H, Jiao Z, Wu M, Liu Y, Wen T. 2010, A protein interaction network for the analysis of the neuronal differentiation of neural stem cells in response to titanium dioxide nanoparticles. Biomaterials. 31(11):3063-3070.
5. Yu T, Wen TQ, Huang H, 2009, study of cell migration using 3 dimension matrix culture system. J Shanghai University 15(5):546-550 (Chinese).
6. Gu S, Huang H, Bi J, Yao Y, Wen T.2009.Combined treatment of neurotrophin-3 gene and neural stem cells is ameliorative to behavior recovery of Parkinson's disease rat model. Brain Res. 1257:1-9.
7. Li ZQ, Liu SP, Yan ZZ, Huang H, 2008, Predicting protein-protein interactions with support vector machines, Electronic Measurement Technology. 31(5):4-8 (Chinese).. 8. Yu YQ, Gu ST , Huang H, Wen TQ. 2007, Combination of bFGF, heparin and laminin deduce the generation of dopaminergic neurons from rat neural stem cells both in vitro and in vivo. J. Neurological Sciences 255:81-86
9. Huang H, Chan H, Wang YY, Ouyang DY, Zheng YT, Tam SC. 2006. Trichosanthin suppress the elevation of p38 MAPK and Bcl-2 induced by HSV-1 infection in Vero cells. Life sciences 79:1287-1292.
10. Wen TQ, Chen YG, Xu WX, Huang H. 2007. A preliminary analysis on the practice and exploration of education without fence. J Shanghai University (Higher Education Science and Administration) 3:67-68(Chinese).
11. Ouyang DY, Chan H, Wang YY, Huang H, Tam SC, Zheng YT. 2006， An inhibitor of c-Jun N-terminal kinases (CEP-11004) counteracts the anti-HIV-1 action of trichosanthin Biochemimcal and Biophysical Research Communications 339(1):25-29.
12. Wang YY, Ouyang DY, Huang H, Chan H, Tam SC, Zheng YT. 2005. Enhanced apoptotic action of trichosanthin in HIV-1 infected cells. Biochemimcaland Biophysical Research Communications 331,1075-1080.
13. Wang JH, Tam SC, Huang H, Ouyang DY, Wang YY, Zheng YT. 2004. Site-directed PEGylation of trichosanthin retained its anti-HIV activity with reduced potency in vitro. Biochemical Biophysical Research Communications 317:965-971.
14. Chan WY , Huang H, Tam SC. 2003. Receptor-mediated endocytosis of trichosanthin in choriocarcinoma cells. Toxicology 186(3):191-203.
15. Wang JH, Nie HL, Huang H, Tam SC, Zheng YT. 2003. Independency of anti-HIV-1 activity from ribosome inactivating activity of trichosanthin. Biochemical Biophysical Research Communications 302: 89-94.
16. Wang JH, Nie HL, Tam SC, Huang H, Zheng YT. 2002. Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity. FEBS Lett. 531(2):295-8.
17. Chan WL, Zheng YT, Huang H, Tam SC. 2001. Relationship between trichosanthin cytotoxicity and its intracellular concentration. Toxicology. 177(2-3):245-51.
18. Zheng YT, Chan WL, Chan P, Huang H, Tam SC, 2001. Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon.
FEBS Lett. 11;496(2-3):139-42.
19. Huang H, Hu X, Guo HW, Ding YM, Lin WG, Xu ZL, Shen ZM. 1999. Preliminary study on the characteristic of a new lipase activator. J. Shanghai University 5 (3): 249-251 (Chinese).
20. Huang H, Ben KL, Zheng YT , 1997, Current status in studying animal models of human aquired immunodeficiency syndrome. Zoological Research 18: 121-128 (Chinese Review).


Patents:
Wen TQ, Gu ST, Bi JQ, Huang H, Yao Y. 2008, Application of neural stem cell (NSCs—NT3) in repairing neuron injury (patent apply number of PRC 2.90).
Li ZQ, Liu SP, Yan ZZ, Xin FY, Huang H. 2006, Preparation method of levofloxacin lactic acid oral adhesive pellicle, (patent apply number of PRC 2.1)

Lecturing Courses (partly):
Immunology, Cell Engineering, An Introduction to Life Science, Immune System and Human Health, Practical Course in Genetics，Comprehensive Laboratory

Contact Information:
School of Life Sciences, Shanghai University
99 Shangda Road, Shanghai 200444, P. R. China
Office Phone: 86- Email: huanghai@staff.shu.edu.cn