钟劲 研究员 | 博士生导师

学科 病毒学

课题组 病毒性肝炎研究组




电话 +86
邮箱 jzhong@sibs.ac.cn
地址 上海市岳阳路320号生命科学实验楼B607

研究方向
病毒性肝炎研究组





个人简介 钟劲，研究员，博士生导师。1994年获四川大学学士学位；1997年获北京大学硕士学位；2003年获美国德克萨斯大学博士学位，随后到美国Scripps研究所做博士后，。2007年受聘中国科学院上海巴斯德研究所研究员。现担任病毒性肝炎研究组研究组长，博士生导师。


学术兼职 上海科技大学**** 上海微生物学会病毒学专业委员会主任 上海市医学会医学病毒学分会副主任


发表论文和专利 部分通讯作者论文
1.Tong, Y.,Li, Q.,Li, R.,Xu,Y., Pan, Y., Niu, J., *Zhong,J., (2020)A novel approach to display structural proteins of HCV quasispecies in patients reveals a key role of E2 HVR1 in viral evolution.J. Virology, 94(17):e00622-20. doi: 10.1128/JVI.00622-20.
2.*Yan, Y., *Wang, X., Lou, P., Hu, Z., Qu, P., Li, D., Li, Q., Xu, Y., Niu, J., He, Y., #Zhong, J., Huang, Z.(2020) A nanoparticle-based HCV vaccine with enhanced potency. J. Infectious Diseases, pii: jiz228. doi: 10.1093/infdis/jiz228. [Epub ahead of print] (*The first two authors contributed equally; #co-corresponding author).
3.Guo, M., Lu, J., Gan, T., Xiang. X., Xu, Y., Xie, Q. and Zhong, J. (2019) Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness. Antiviral Research, 171, 104612.
4.Zhao, Y., Cao, X., Guo, M., Wang, X., Yu, T., Ye. L., Han, L., Hei, L., Tao. W., Tong Y., Xu, Y. and Zhong, J. (2018) Neuralized E3 Ubiquitin Protein Ligase 3 is an inducible antiviral effector to inhibit HCV assembly by targeting viral E1 glycoprotein. J. Virology, 92(21). pii: e01123-18. JVI spotlight.
5.*Liang, Y., *Cao, X., Ding, Q., Zhao, Y., He, Z.,Zhong, J.(2018) Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway.PLOS Pathogens.14(5):e** (*The first two authors contributed equally).
6.Li, Q., Tong Y., Xu, Y.,#Niu, J.,#Zhong, J.(2018) Genetic Analysis of Serum-derived Defective Hepatitis C Virus Genomes Revealed Novel Viral Cis-Elements for Virus Replication and Assembly.J. Virology, 92(7). pii: e02182-17 (#corresponding author).
7.*Wang, X., *Yan, Y., Gan, T., Yang, X., Li, D., Zhou, D., Sun, Q.,#Huang, Z.,#Zhong, J.(2017) A trivalent HCV vaccine elicits broad and synergistic polyclonal antibody response in mice and rhesus monkey.Gut, doi: 10.1136/gutjnl-2017-314870.(*The first two authors contributed equally;#corresponding author).
8.*Tao, W., *Gan T., Guo, M., Xu, Y.,Zhong, J.(2017) Novel Stable Ebola Virus Minigenome Replicon Reveals Remarkable Stability of the Viral Genome.J. Virology, 91: 22e01316-17(*The first two authors contributed equally). JVI spotlight.
9.Li, D., Wang, X., von Schaewen, M., Tao, W., Zhang, Y., Heller, B., Hrebikova, G., Deng, Q., Sun, Q.,#Ploss, A.,#Zhong, J.,#Huang, Z. (2017) Immunization with a subunit hepatitis C virus vaccine elicits pan-genotypic neutralizing antibodies and intra-hepatic T-cell responses in non-human primates.J. Infectious Diseases, 215(12):1824-1831 (#corresponding author).
10.*Cao, R., *Xu, Y., Zhang, T., Yang, J., Yuan, Y., Hao, P., Shi, Y.,#Zhong, J.,#Zhong, W. (2017) Pediatric drug nitazoxanide: a potential choice for control of Zika.Open Forum Infectious Diseases, 4(1):ofx009 (*The first two authors contributed equally;#corresponding author).
11.Tong, Y., Chi, X., Yang, W.,Zhong, J.(2017) Functional analysis of HCV envelope protein E1 using a trans-complementation system reveals a dual role of a putative fusion peptide of E1 in both HCV entry and morphogenesis.J. Virology, 91:7 16 e02468-16
12.Hei, L. andZhong, J.(2017) LGP2 plays an essential role in HCV infection-induced interferon responses.Hepatology, 65(5):1478-1491.
13.*Yan, Y., *He, Y., Boson, B., Wang, X., Cosset, F.L.,Zhong, J.(2017) A point mutation in the N-terminal amphiphathic helix α0 in NS3 promotes HCV assembly by altering core localization to ER and facilitating virus budding.J. Virology, 91(6). pii: e02399-16(*The first two authors contributed equally).
14.Li, D., von Schaewen, M., Wang, X., Tao, W., Zhang, Y., Li, L., Heller, B., Hrebikova, G., Deng, Q.,#Ploss, A.,#Zhong, J.,#Huang, Z. (2016) Altered glycosylation patterns increase immunogenicity of a subunit HCV vaccine inducing neutralizing antibodies which confer protection in mice.J. Virology, 90:10486-10498 (#corresponding author).
15.Xiang, Y., Tang, J., Tao, W., Cao, X., Song, B. andZhong, J. (2015) Identification of cholesterol-25-hydroxylase as a novel host restriction factor as a part of primary innate immune responses against hepatitis C virus infection.J. Virology, 89:6805–6816.
16.*Cao, X., *Ding, Q., Lu J., Tao, W., Huang, B., Zhao, Y., Niu, J., Liu, Y.J. andZhong, J. (2015) MDA5 Plays a Critical Role in Interferon Response during Hepatitis C Virus Infection.J. Hepatology. 62:771–778(*The first two authors contributed equally) .
17.Lu, J., Xiang, Y., Tao, W., Li, Q., Wang, N., Gao, Y., Xiang, X., Xie, Q., andZhong, J. (2014)A novel strategy to develop robust infectious hepatitis C virus cell culture system directly from a clinical isolate.J. Virology, 88, 1484-1491.
18.*Ding, Q., *Cao, X., Lu J., Huang, B., Liu, Y.J., Kato, N., Shu, H., andZhong, J. (2013) Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity.J. Hepatology. 59(1):52-58(*The first two authors contributed equally).
19.Ding, Q., Huang, B., Lu, J., Liu, Y.J., andZhong, J. (2012) Hepatitis C virus NS3/4A protease blocks IL-28 production.European J. Immunology, 42, 2374-82.
20.Li, R., Qin, Y., He, Y., Tao, W., Zhang, N., Tsai, C., Zhou, P.,Zhong, J.(2011) Production of hepatitis C virus lacking the envelope-encoding genes for single-cycle infection by providing homologous envelope proteins or vesicular stomatitis virus glycoproteins in trans.J.Virology,85,2138-2147.
21.Tao, W., Xu, C., Ding, Q., Li, R., Xiang, Y., Chung, J., andZhong, J. (2009) A Single Point Mutation in E2 Enhances Hepatitis C Virus Infectivity and Alters Lipoprotein Association of Viral Particles.Virology, 395, 67–76.


科研进展和成果

奖励荣誉

实验室介绍 本实验室研究重要RNA病毒病原体的分子病毒学、细胞生物学、固有免疫应答以及抗病毒疫苗和药物的研发，主要研究对象包括丙型肝炎病毒（HCV）、埃博拉病毒（EBOV）、寨卡病毒（ZIKV）等。HCV能导致急性和慢性肝炎以及肝癌。近年来慢性丙肝的治疗研究有了很大的进展，但是由于缺乏丙肝疫苗，丙肝问题仍然威胁着人类的健康。HCV作为一个正链RNA模式病毒，遗传多样性高。其病毒颗粒与宿主来源的脂蛋白复合物高度关联，在其生命周期和宿主相互作用上具有鲜明的特点。EBOV和ZIKV是新发突发致病性RNA病毒，近年来多次引起全球或区域流行，给世界公共卫生健康造成较大的威胁。我们在分子及细胞水平上研究这些RNA病毒感染的生物学机制，阐明病毒学、免疫学和细胞生物学中重要的科学问题，找到更好的途径和手段来预防和治疗病毒感染。
实验室成员(Lab member)
副研究员：徐咏芬 博士、童一民 博士
科研秘书：夏佳梦
国科大博士研究生：甘天喻、杨乾坤、STEVE LEUMI YATCHOUKEU、邢一帆、叶思超、
田芳玲
国科大硕士研究生：胡逍悠、JACKLINE WANGU NGARI、李林灿
上科大博士研究生：梁轶莎、韩林、娄佩兰
上科大硕士研究生：马子越、刘超仑
毕业研究生(Graduate student)
已毕业博士研究生：陶万银、何莹、李瑞、丁强、卢捷、曹学智、向禹、黑蕾、于涛、颜雨、
李庆超、王雪松、赵亚楠、何振亮、郭明哲
已毕业硕士研究生：叶丽清、谢磊
已毕业联合培养博士研究生：项晓刚、李大鹏
招生信息(admission information)
欢迎优秀学生加入本团队攻读硕士和博士研究生。
欢迎大学二年级（含）以上同学进入实验室参与有关科研学术工作，或联系毕业设计等。